Gene: PRDM2

7799
HUMHOXY1|KMT8|KMT8A|MTB-ZF|RIZ|RIZ1|RIZ2
PR/SET domain 2
protein-coding
1p36.21
Ensembl:ENSG00000116731 MIM:601196 Vega:OTTHUMG00000007917 UniprotKB:Q13029
NC_000001.11
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.519e-1 (AD)  5.152e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2014788chr1:13799958 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPME10.953
ATG16L10.947
TSPAN50.947
HERC10.946
DOCK30.945
MADD0.945
LARP10.944
NUDCD30.943
STXBP10.94
TBC1D250.939

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.533
OR4F29-0.515
MYL3-0.458
PHEX-0.454
RNF135-0.452
HEY2-0.445
YES1-0.438
RAB13-0.436
COPZ2-0.435
ASB4-0.435

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of PRDM2 mRNA"19095052
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PRDM2 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of PRDM2 mRNA"18648102
C5830744,4'-hexafluorisopropylidene diphenol"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PRDM2 protein modified form]"28751236
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRDM2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRDM2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of PRDM2 mRNA21420995|2906747
D020106AcrylamideAcrylamide results in increased expression of PRDM2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PRDM2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PRDM2 mRNA19770486
D000638AmiodaroneAmiodarone results in increased expression of PRDM2 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PRDM2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PRDM2 mRNA24449571
D001151ArsenicArsenic results in increased methylation of PRDM2 promoter21291286
D001152ArsenicalsArsenicals results in increased methylation of PRDM2 promoter26039340
C058317arsenic disulfidearsenic disulfide results in decreased expression of PRDM2 mRNA12890387
C006780bisphenol A[bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PRDM2 protein modified form]28751236
C006780bisphenol Abisphenol A results in increased expression of PRDM2 mRNA28765096
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRDM2 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of PRDM2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PRDM2 gene28505145
D000069286BortezomibBortezomib results in decreased expression of PRDM2 mRNA20977926
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PRDM2 mRNA19010381
D002922CiguatoxinsCiguatoxins affects the expression of PRDM2 mRNA18353800
C018021cobaltous chloridecobaltous chloride results in increased expression of PRDM2 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of PRDM2 mRNA24386269
D003042CocaineCocaine results in increased expression of PRDM2 mRNA17898221
D019327Copper SulfateCopper Sulfate results in increased expression of PRDM2 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of PRDM2 mRNA19770486
C014347decitabinedecitabine affects the expression of PRDM2 mRNA17103461
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRDM2 mRNA28628672
D004041Dietary FatsDietary Fats results in increased expression of PRDM2 mRNA25016146
D004397FonofosFonofos results in increased methylation of PRDM2 promoter22847954
C039281furanfuran results in decreased expression of PRDM2 mRNA24614236
D005839GentamicinsGentamicins results in decreased expression of PRDM2 mRNA22061828
D005839GentamicinsGentamicins results in increased expression of PRDM2 mRNA22061828
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRDM2 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PRDM2 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRDM2 mRNA28628672
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PRDM2 mRNA26378955
D008694MethamphetaminePRDM2 gene SNP affects the susceptibility to Methamphetamine18316681
D008727MethotrexateMethotrexate results in decreased expression of PRDM2 mRNA24449571
D015741Metribolone[Metribolone binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PRDM2 protein modified form]28751236
C028007nickel monoxidenickel monoxide results in increased expression of PRDM2 mRNA19167457
D009569Nitric OxideNitric Oxide results in increased expression of PRDM2 mRNA23546878
D010278ParathionParathion results in increased methylation of PRDM2 promoter22847954
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of PRDM2 mRNA19095052
D010634PhenobarbitalPhenobarbital affects the expression of PRDM2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of PRDM2 mRNA19270015
D010938Plant OilsPlant Oils results in increased expression of PRDM2 mRNA23370395
D011192Potassium DichromatePotassium Dichromate results in decreased expression of PRDM2 mRNA23608068
C059514resveratrolresveratrol results in decreased expression of PRDM2 mRNA12569576
D012643SeleniumSelenium results in increased expression of PRDM2 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in increased expression of PRDM2 mRNA25351596
C017947sodium arsenitesodium arsenite affects the expression of PRDM2 mRNA29319823
C017947sodium arsenitesodium arsenite results in decreased expression of PRDM2 protein21925251
D012999SomanSoman results in decreased expression of PRDM2 mRNA19281266
D012999SomanSoman results in increased expression of PRDM2 mRNA19281266
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PRDM2 mRNA26378955
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of PRDM2 mRNA"26680231
C061133tamibarotenetamibarotene affects the expression of PRDM2 mRNA15498508
C012568terbufosterbufos results in increased methylation of PRDM2 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PRDM2 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRDM2 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PRDM2 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of PRDM2 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PRDM2 mRNA28065790
D014212TretinoinTretinoin affects the expression of PRDM2 mRNA15498508
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRDM2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of PRDM2 mRNA26272509
C057693troglitazonetroglitazone results in decreased expression of PRDM2 mRNA28973697
D014520UrethaneUrethane results in increased expression of PRDM2 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of PRDM2 mRNA23179753
C025643vinclozolinvinclozolin affects the expression of PRDM2 mRNA19015723
D014810Vitamin EVitamin E results in decreased expression of PRDM2 mRNA19244175
D014810Vitamin EVitamin E results in increased expression of PRDM2 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of PRDM2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IMP8654390  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA8654390  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IMP8654390  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-NAS7590293  8654390  
GO:0008270zinc ion binding-NAS7538672  
GO:0018024histone-lysine N-methyltransferase activity-IEA-  
GO:0031490chromatin DNA binding-IBA21873635  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-NAS7590293  8654390  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0008340determination of adult lifespan-IEA-  
GO:0034968histone lysine methylation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA8654390  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA11544182  
GO:0005634nucleus-NAS7538672  7590293  
GO:0005794Golgi apparatus-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26683928Genomic Copy Number Variations Characterize the Prognosis of Both P16-Positive and P16-Negative Oropharyngeal Squamous Cell Carcinoma After Curative Resection. (2015 Dec)Rhie AMedicine (Baltimore)
27573876Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2. (2017 Dec)Barbier EMol Psychiatry