Gene info: ID 780

Gene: DDR1

GENE ID: 780

Synonyms: CAK|CD167|DDR|EDDR1|HGK2|MCK10|NEP|NTRK4|PTK3|PTK3A|RTK6|TRKE

Description: discoidin domain receptor tyrosine kinase 1

Gene type: protein-coding

Location: 6p21.33

dbXrefs: Ensembl:ENSG00000204580 MIM:600408 Vega:OTTHUMG00000031236 UniprotKB:Q08345

RefSeq: NG_029066.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PLXNB1	0.906
ITPKB	0.899
COMT	0.897
PLCD1	0.886
GPRC5B	0.883
LRIG1	0.883
FBXL7	0.88
ABHD4	0.877
PON2	0.877
CYP27A1	0.875

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.475
TYRP1	-0.464
OR4F29	-0.453
ABCC12	-0.442
MCHR1	-0.431
RTP1	-0.429
MYOZ3	-0.428
FBLN7	-0.425
PRSS12	-0.425
CALHM1	-0.422

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00619	Imatinib	Small Molecule	152459-95-5	Approved	Target

ID	Drug Name	Action	PubMed
C569107	1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one	"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in decreased expression of DDR1 mRNA"	23826121
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDR1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDR1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDR1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDR1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of DDR1 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of DDR1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of DDR1 mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of DDR1 mRNA	23630614
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of DDR1 mRNA	16483693
C015001	arsenite	arsenite results in increased expression of DDR1 mRNA	18191166
D001280	Atrazine	Atrazine results in increased expression of DDR1 mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of DDR1 mRNA	19770486\|2373587
C006780	bisphenol A	bisphenol A results in increased expression of DDR1 mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of DDR1 mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DDR1 mRNA	28628672
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of DDR1 mRNA	15336504
C018475	butyraldehyde	butyraldehyde results in decreased expression of DDR1 mRNA	26079696
D002087	Butyrates	Butyrates results in increased expression of DDR1 mRNA	14674679
D002118	Calcium	Calcium affects the expression of DDR1 mRNA	15913539
D002220	Carbamazepine	Carbamazepine affects the expression of DDR1 mRNA	24752500
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of DDR1 mRNA	17484886
C062876	cetrorelix	[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in increased expression of DDR1 mRNA	18160741
C062876	cetrorelix	[cetrorelix co-treated with testosterone enanthate] results in increased expression of DDR1 mRNA	18160741
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DDR1 mRNA	20938992
D003471	Cuprizone	Cuprizone results in decreased expression of DDR1 mRNA	26577399\|2752363
D016572	Cyclosporine	Cyclosporine results in decreased expression of DDR1 mRNA	27989131
D016572	Cyclosporine	Cyclosporine results in increased expression of DDR1 mRNA	25562108
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of DDR1 mRNA	23640034
D017135	Desogestrel	[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in increased expression of DDR1 mRNA	18160741
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DDR1 mRNA	28628672
D003976	Diazinon	Diazinon results in increased methylation of DDR1 gene	22964155
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of DDR1 mRNA	17361019\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of DDR1 mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of DDR1 mRNA	27392435
D002945	Cisplatin	DDR1 protein affects the susceptibility to Cisplatin	16217747
D002945	Cisplatin	Cisplatin results in increased expression of DDR1 mRNA	21151649
D004008	Diclofenac	Diclofenac affects the expression of DDR1 mRNA	24752500
D004040	Dietary Carbohydrates	Dietary Carbohydrates results in decreased expression of DDR1 mRNA	17490981
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of DDR1 mRNA	24535843
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of DDR1 mRNA	15766595
D002117	Calcitriol	Calcitriol results in increased expression of DDR1 mRNA	26485663
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of DDR1 mRNA	23649840
D005047	Etoposide	Etoposide results in increased expression of DDR1 mRNA	25270620
D005419	Flavonoids	Flavonoids results in increased expression of DDR1 mRNA	18035473
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of DDR1 mRNA	17187413
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DDR1 mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of DDR1 mRNA	23649840
C039281	furan	furan results in increased methylation of DDR1 gene	22079235
D017313	Fenretinide	Fenretinide results in decreased expression of DDR1 mRNA	28973697
D017313	Fenretinide	Fenretinide results in increased expression of DDR1 mRNA	28973697
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DDR1 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DDR1 mRNA	28628672
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of DDR1 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of DDR1 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of DDR1 mRNA	26752646
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DDR1 mRNA	20938992
C004925	methylmercuric chloride	methylmercuric chloride affects the expression of DDR1 mRNA	20864626
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of DDR1 mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of DDR1 mRNA	23649840
D015735	Mifepristone	Mifepristone results in decreased expression of DDR1 mRNA	25972201
D016685	Mitomycin	DDR1 protein affects the susceptibility to Mitomycin	16217747
C568376	MT19c compound	MT19c compound results in decreased expression of DDR1 mRNA	21781307
C000621033	napabucasin	napabucasin results in decreased expression of DDR1 mRNA	25605917
C029938	nickel sulfate	nickel sulfate results in increased expression of DDR1 mRNA	22714537
C042670	N-vinyl-2-pyrrolidinone	[N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which results in increased expression of DDR1 mRNA	22037397
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of DDR1 mRNA	18692542
D010634	Phenobarbital	Phenobarbital results in increased expression of DDR1 mRNA	22037397
D010936	Plant Extracts	Plant Extracts results in decreased expression of DDR1 mRNA	23557933
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of DDR1 mRNA	11678601
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of DDR1 mRNA	24780913
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of DDR1 mRNA	27029645
D017382	Reactive Oxygen Species	[[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of DDR1 mRNA	27634759
D012906	Smoke	Smoke results in decreased expression of DDR1 mRNA	21095227
C017947	sodium arsenite	sodium arsenite results in decreased expression of DDR1 mRNA	20371982
C017947	sodium arsenite	sodium arsenite results in decreased methylation of DDR1 gene	24570342
C017947	sodium arsenite	sodium arsenite results in increased expression of DDR1 mRNA	24570342
D012999	Soman	Soman results in increased expression of DDR1 mRNA	19281266
C004648	testosterone enanthate	[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in increased expression of DDR1 mRNA	18160741
C004648	testosterone enanthate	[cetrorelix co-treated with testosterone enanthate] results in increased expression of DDR1 mRNA	18160741
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DDR1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to DDR1 promoter]	19654925
D013853	Thioacetamide	Thioacetamide results in increased expression of DDR1 mRNA	23411599
D014212	Tretinoin	Tretinoin results in decreased expression of DDR1 mRNA	21934132\|2372400
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDR1 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of DDR1 mRNA	26272509
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDR1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of DDR1 mRNA	24849673
D014635	Valproic Acid	Valproic Acid results in decreased expression of DDR1 mRNA	23179753\|2438349
C088658	zoledronic acid	zoledronic acid results in increased expression of DDR1 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004709	MAP kinase kinase kinase activity	-	IBA	21873635
GO:0004713	protein tyrosine kinase activity	-	IBA	21873635
GO:0004714	transmembrane receptor protein tyrosine kinase activity	-	IBA	21873635
GO:0004714	transmembrane receptor protein tyrosine kinase activity	-	TAS	9659899
GO:0004888	transmembrane signaling receptor activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	16337946 18190796
GO:0005518	collagen binding	-	IBA	21873635
GO:0005518	collagen binding	-	IDA	9659899
GO:0005518	collagen binding	-	IMP	12065315
GO:0005524	ATP binding	-	IEA	-
GO:0031434	mitogen-activated protein kinase kinase binding	-	IBA	21873635
GO:0038062	protein tyrosine kinase collagen receptor activity	-	IBA	21873635
GO:0038062	protein tyrosine kinase collagen receptor activity	-	IDA	9659899 21044884
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001558	regulation of cell growth	-	IEA	-
GO:0001952	regulation of cell-matrix adhesion	-	IEA	-
GO:0007155	cell adhesion	-	TAS	8302582
GO:0007275	multicellular organism development	-	IBA	21873635
GO:0007566	embryo implantation	-	IEA	-
GO:0007595	lactation	-	IEA	-
GO:0008285	negative regulation of cell proliferation	-	IEA	-
GO:0009968	negative regulation of signal transduction	-	IBA	21873635
GO:0010715	regulation of extracellular matrix disassembly	-	IMP	12065315
GO:0014909	smooth muscle cell migration	-	IMP	12065315
GO:0030154	cell differentiation	-	IBA	21873635
GO:0030198	extracellular matrix organization	-	TAS	-
GO:0033674	positive regulation of kinase activity	-	IBA	21873635
GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	-	IDA	9659899 21044884
GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	-	IMP	12065315
GO:0038083	peptidyl-tyrosine autophosphorylation	-	IDA	21044884
GO:0043066	negative regulation of apoptotic process	-	IBA	21873635
GO:0043583	ear development	-	IEA	-
GO:0044319	wound healing, spreading of cells	-	IBA	21873635
GO:0044319	wound healing, spreading of cells	-	IMP	12065315
GO:0046777	protein autophosphorylation	-	IDA	9659899
GO:0060444	branching involved in mammary gland duct morphogenesis	-	IEA	-
GO:0060749	mammary gland alveolus development	-	IEA	-
GO:0061302	smooth muscle cell-matrix adhesion	-	IMP	12065315
GO:0061564	axon development	-	IEA	-
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IBA	21873635
GO:1990138	neuron projection extension	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	HDA	16502470
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	IEA	-
GO:0043235	receptor complex	-	IBA	21873635
GO:0043235	receptor complex	-	IDA	23382219
GO:0070062	extracellular exosome	-	HDA	19199708

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-3000171	Non-integrin membrane-ECM interactions	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22380734	Potential association of DDR1 genetic variant with FEV1 decline by aspirin provocation in asthmatics. (2012 Apr)	Kim JY	J Asthma