Gene: LRP8

7804
APOER2|HSZ75190|LRP-8|MCI1
LDL receptor related protein 8
protein-coding
1p32.3
Ensembl:ENSG00000157193 MIM:602600 Vega:OTTHUMG00000008924 UniprotKB:Q14114
NG_011517.2
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.967e-2 (AD)  7.836e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3820198chr1:53326979 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NF10.848
SORL10.838
IPO90.833
GSK3B0.83
TMOD20.828
SLC25A160.826
NDUFS10.826
VPS360.825
TMEM132B0.825
GPRASP10.823

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.517
OR4F29-0.486
FXYD3-0.391
ROM1-0.391
SNHG18-0.384
TGFB3-0.378
ANXA13-0.371
SGMS2-0.358
SH2D1A-0.358
RAB13-0.356

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of LRP8 mRNA"20453058
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LRP8 mRNA"19114083
C0127962-butenal2-butenal results in decreased expression of LRP8 mRNA20471460
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRP8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRP8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRP8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRP8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRP8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRP8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRP8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRP8 mRNA"27188386
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of LRP8 mRNA"26238291
D000082AcetaminophenAcetaminophen results in increased expression of LRP8 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of LRP8 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LRP8 mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LRP8 mRNA22100608
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of LRP8 mRNA24449571
D001151ArsenicArsenic affects the methylation of LRP8 gene25304211
D001280AtrazineAtrazine results in decreased expression of LRP8 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LRP8 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of LRP8 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LRP8 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LRP8 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LRP8 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LRP8 mRNA"19150397|2001819
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of LRP8 mRNA20660070
D004958EstradiolEstradiol results in increased expression of LRP8 mRNA23019147
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LRP8 mRNA28628672
C006780bisphenol Abisphenol A results in decreased methylation of LRP8 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of LRP8 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of LRP8 mRNA17484886
C018021cobaltous chloridecobaltous chloride results in decreased expression of LRP8 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in increased expression of LRP8 mRNA20105288
D003300Copper[Disulfiram binds to Copper] which results in increased expression of LRP8 mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of LRP8 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of LRP8 mRNA19549813
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of LRP8 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of LRP8 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of LRP8 mRNA20106945|2556210
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LRP8 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of LRP8 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of LRP8 mRNA28302478
C042080diisodecyl phthalatediisodecyl phthalate results in decreased expression of LRP8 mRNA25270620
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of LRP8 mRNA24690739
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of LRP8 mRNA23649840
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of LRP8 mRNA27776689
C082360fipronilfipronil results in decreased expression of LRP8 mRNA23962444
D005472FluorouracilFluorouracil results in decreased expression of LRP8 mRNA16101138
C061365flusilazoleflusilazole affects the expression of LRP8 mRNA21195148
D005557FormaldehydeFormaldehyde results in decreased expression of LRP8 mRNA23649840
D019833GenisteinGenistein results in increased expression of LRP8 mRNA23019147
C409722hexaconazolehexaconazole affects the expression of LRP8 mRNA21195148
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LRP8 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LRP8 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of LRP8 mRNA27392435
C544151jinfukangjinfukang results in increased expression of LRP8 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LRP8 mRNA22904298|2343069
C410337K 7174K 7174 results in increased expression of LRP8 mRNA24086573
C045463leflunomideleflunomide results in increased expression of LRP8 mRNA28988120
C025340manganese chloridemanganese chloride results in increased expression of LRP8 mRNA22407947
D008627Mercuric ChlorideMercuric Chloride results in increased expression of LRP8 mRNA16507785
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of LRP8 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRP8 mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LRP8 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LRP8 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of LRP8 mRNA"20188158
D009151Mustard GasMustard Gas results in decreased expression of LRP8 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LRP8 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of LRP8 mRNA19812364
D009532NickelNickel results in increased expression of LRP8 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of LRP8 mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of LRP8 mRNA20971185
D010100OxygenOxygen deficiency results in decreased expression of LRP8 mRNA26516004
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRP8 mRNA"27188386
D010575PesticidesPesticides results in increased methylation of LRP8 gene28396702
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRP8 mRNA"27188386
C006253pirinixic acidpirinixic acid results in increased expression of LRP8 mRNA20813756
D011192Potassium DichromatePotassium Dichromate results in decreased expression of LRP8 mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of LRP8 mRNA20660070
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of LRP8 mRNA19167446
D012524SarinSarin results in increased expression of LRP8 mRNA19522546
D012643SeleniumLRP8 protein affects the abundance of Selenium17314095|1755399
D012643SeleniumLRP8 protein affects the susceptibility to Selenium18172410
D012643SeleniumLRP8 protein results in increased uptake of Selenium19007311
C017947sodium arsenitesodium arsenite results in increased expression of LRP8 mRNA25493608
C021751tanshinonetanshinone results in decreased expression of LRP8 mRNA15849732
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LRP8 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LRP8 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LRP8 mRNA19770486
D019284ThapsigarginThapsigargin results in decreased expression of LRP8 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of LRP8 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of LRP8 mRNA22363418
D014212TretinoinTretinoin results in decreased expression of LRP8 mRNA21934132
C032910triadimefontriadimefon affects the expression of LRP8 mRNA21195148
C012589trichostatin Atrichostatin A affects the expression of LRP8 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of LRP8 mRNA27188386
D014415TunicamycinTunicamycin results in decreased expression of LRP8 mRNA22378314
D014520UrethaneUrethane results in decreased expression of LRP8 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRP8 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of LRP8 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LRP8 mRNA23179753|2627250
D014750VincristineVincristine results in decreased expression of LRP8 mRNA23649840
C111237vorinostatvorinostat results in decreased expression of LRP8 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-TAS8626535  
GO:0005041low-density lipoprotein particle receptor activity-TAS20005821  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI12950167  17548821  19116273  20223215  
GO:0008035high-density lipoprotein particle binding-IEA-  
GO:0019894kinesin binding-IEA-  
GO:0030229very-low-density lipoprotein particle receptor activity-IDA8626535  
GO:0034185apolipoprotein binding-IC8626535  
GO:0038025reelin receptor activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0001523retinoid metabolic process-TAS-  
GO:0006508proteolysis-NAS11152697  
GO:0006629lipid metabolic process-NAS11152697  
GO:0006897endocytosis-IDA8626535  
GO:0006898receptor-mediated endocytosis-IEA-  
GO:0007165signal transduction-TAS10380922  
GO:0019221cytokine-mediated signaling pathway-NAS11152697  
GO:0021541ammon gyrus development-ISS-  
GO:0021987cerebral cortex development-IEA-  
GO:0032793positive regulation of CREB transcription factor activity-ISS-  
GO:0038026reelin-mediated signaling pathway-ISS-  
GO:0042493response to drug-IEA-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-ISS-  
GO:0050804modulation of chemical synaptic transmission-ISS-  
GO:0061003positive regulation of dendritic spine morphogenesis-ISS-  
GO:0061098positive regulation of protein tyrosine kinase activity-ISS-  
GO:0071363cellular response to growth factor stimulus-IEA-  
GO:0071397cellular response to cholesterol-IEA-  
GO:1900006positive regulation of dendrite development-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005875microtubule associated complex-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005901caveola-IDA11369809  
GO:0014069postsynaptic density-IEA-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IC11152697  
GO:0030424axon-IEA-  
GO:0030425dendrite-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043235receptor complex-IDA23382219  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-2187338Visual phototransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418346Platelet homeostasisTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-432142Platelet sensitization by LDLTAS
R-HSA-6806667Metabolism of fat-soluble vitaminsTAS
R-HSA-975634Retinoid metabolism and transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22404453Genetic variant R952Q in LRP8 is associated with increased plasma triglyceride levels in patients with early-onset CAD and MI. (2012 May)Shen GQAnn Hum Genet