Gene: CACNA2D1

781
CACNA2|CACNL2A|CCHL2A|LINC01112|lncRNA-N3
calcium voltage-gated channel auxiliary subunit alpha2delta 1
protein-coding
7q21.11
Ensembl:ENSG00000153956 MIM:114204 Vega:OTTHUMG00000023622 UniprotKB:P54289
NG_009358.2
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.136e-1 (AD)  6.268e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6975142chr7:82388133 (GRCh38.p7)A>C / A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6942458chr7:82153198 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHL10.958
GRIA20.956
SCN2A0.955
GABRB30.953
FGF140.948
SLC2A130.948
SCAMP10.948
ELOVL40.946
ATP2B10.945
CSRNP30.945

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.555
FZD10-0.52
RUNX3-0.502
CNN2-0.496
AJUBA-0.495
RNF135-0.484
TFPI2-0.481
MAGEA12-0.478
RAI14-0.474
KCNJ15-0.467

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00270IsradipineSmall Molecule75695-93-1Approved|InvestigationalTarget
DB00308IbutilideSmall Molecule122647-31-8ApprovedTarget
DB00381AmlodipineSmall Molecule88150-42-9ApprovedTarget
DB00401NisoldipineSmall Molecule63675-72-9ApprovedTarget
DB00622NicardipineSmall Molecule55985-32-5Approved|InvestigationalTarget
DB00653Magnesium sulfateSmall Molecule7487-88-9Approved|InvestigationalTarget
DB00996GabapentinSmall Molecule60142-96-3Approved|InvestigationalTarget
DB01023FelodipineSmall Molecule72509-76-3Approved|InvestigationalTarget
DB01054NitrendipineSmall Molecule39562-70-4Approved|InvestigationalTarget
DB01115NifedipineSmall Molecule21829-25-4ApprovedTarget
DB04838CyclandelateSmall Molecule456-59-7ApprovedTarget
DB06712NilvadipineSmall Molecule75530-68-6Approved|InvestigationalTarget
DB08872Gabapentin EnacarbilSmall Molecule478296-72-9Approved|InvestigationalTarget
DB00421SpironolactoneSmall Molecule52-01-7ApprovedTarget
ID Drug Name Action PubMed
C4118272,5-dihydro-2,4,5-trimethylthiazoline"2,5-dihydro-2,4,5-trimethylthiazoline results in increased expression of CACNA2D1 protein"22849384
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CACNA2D1 mRNA"15059925
C5037722-aminomethyl-2-tricyclo(3.3.1.1(1,7))decaneacetic acid hydrochloride"2-aminomethyl-2-tricyclo(3.3.1.1(1,7))decaneacetic acid hydrochloride results in decreased activity of CACNA2D1 protein"21059371
C5037722-aminomethyl-2-tricyclo(3.3.1.1(1,7))decaneacetic acid hydrochloride"CACNA2D1 protein results in increased susceptibility to [2-aminomethyl-2-tricyclo(3.3.1.1(1,7))decaneacetic acid hydrochloride affects the activity of [CACNA1D protein co-treated with CACNB3 protein]]"19796812
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D1 mRNA"27188386
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CACNA2D1 mRNA25607892
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CACNA2D1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CACNA2D1 gene28458013
D000393Air PollutantsAir Pollutants analog results in decreased expression of CACNA2D1 mRNA21757418
D000393Air Pollutants[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of CACNA2D1 gene28843141
D006710HomocysteineHomocysteine analog binds to CACNA2D1 protein16380257
D000639AmitriptylineAmitriptyline results in increased expression of CACNA2D1 mRNA22341215
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CACNA2D1 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of CACNA2D1 mRNA"22863853
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CACNA2D1 mRNA25607892
C006632arsenic trioxidearsenic trioxide results in increased expression of CACNA2D1 mRNA20458559
D001194AsbestosAsbestos results in decreased expression of CACNA2D1 mRNA22398240
D001464BariumCACNA2D1 protein affects the transport of Barium15245474
D001464BariumCACNA2D1 protein affects the transport of Barium11313431
D001464BariumCACNA2D1 protein results in increased transport of Barium15474003
D001554BenzeneBenzene analog binds to CACNA2D1 protein16380257
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CACNA2D1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CACNA2D1 mRNA23735875
C006780bisphenol Abisphenol A affects the expression of CACNA2D1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CACNA2D1 mRNA25607892
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CACNA2D1 mRNA25607892
C006780bisphenol Abisphenol A results in increased methylation of CACNA2D1 gene28505145
C013418bromfenacoumbromfenacoum results in increased expression of CACNA2D1 protein28903499
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CACNA2D1 mRNA25607892
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CACNA2D1 mRNA25607892
C018475butyraldehydebutyraldehyde results in decreased expression of CACNA2D1 mRNA26079696
D002118CalciumCACNA2D1 protein affects the reaction [Potassium Chloride results in increased transport of Calcium]17881535
D002118Calcium[gabapentin results in decreased activity of CACNA2D1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]17442347
D002118CalciumCACNA2D1 protein promotes the reaction [[CACNA1D protein co-treated with CACNB3 protein] results in increased transport of Calcium]19796812
D002118CalciumCACNA2D1 protein results in increased transport of Calcium15474003|1979681
D002118CalciumCACNA2D1 protein results in increased import of Calcium25504062
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CACNA2D1 mRNA20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of CACNA2D1 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of CACNA2D1 mRNA26577399
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CACNA2D1 mRNA16054899
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CACNA2D1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CACNA2D1 mRNA27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CACNA2D1 mRNA18164116
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CACNA2D1 mRNA"22485181
C118739entinostatentinostat results in decreased expression of CACNA2D1 mRNA27188386
C118739entinostatentinostat results in increased expression of CACNA2D1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D1 mRNA"27188386
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CACNA2D1 mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CACNA2D1 mRNA25607892
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of CACNA2D1 mRNA17347304
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of CACNA2D1 mRNA17347304
D005419FlavonoidsFlavonoids results in increased expression of CACNA2D1 mRNA18035473
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of CACNA2D1 mRNA17187413
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CACNA2D1 mRNA20938992
C039281furanfuran results in decreased methylation of CACNA2D1 gene27387713
C039281furanfuran results in increased expression of CACNA2D1 mRNA27387713
C040029gabapentin[gabapentin binds to and results in decreased activity of CACNA2D1 protein] which results in decreased susceptibility to Methamphetamine20340177
C040029gabapentin[gabapentin binds to and results in decreased activity of CACNA2D1 protein] which results in decreased susceptibility to Potassium Chloride17881535
C040029gabapentingabapentin binds to CACNA2D1 protein16380257
C040029gabapentingabapentin inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]21182903
C040029gabapentin[gabapentin results in decreased activity of CACNA2D1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]17442347
C040029gabapentinCACNA2D1 protein results in increased susceptibility to [gabapentin affects the activity of [CACNA1D protein co-treated with CACNB3 protein]]19796812
C040029gabapentingabapentin binds to CACNA2D1 protein16380257
C040029gabapentingabapentin binds to CACNA2D1 protein11687876
C040029gabapentingabapentin binds to and results in decreased activity of CACNA2D1 protein17881535|2034017
C040029gabapentingabapentin binds to CACNA2D1 protein14660671|2105937
D007461IodoacetatesIodoacetates results in increased expression of CACNA2D1 mRNA19664204
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CACNA2D1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CACNA2D1 mRNA16054899
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CACNA2D1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of CACNA2D1 mRNA27392435
D007854LeadLead results in decreased expression of CACNA2D1 mRNA19921347
C045463leflunomideleflunomide results in decreased expression of CACNA2D1 mRNA19751817
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CACNA2D1 mRNA25613284
D008694MethamphetamineCACNA2D1 protein affects the susceptibility to Methamphetamine21182903
D008694MethamphetamineDRD1 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]20340177
D008694MethamphetamineDRD1 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 protein]20340177
D008694MethamphetamineDRD2 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]20340177
D008694MethamphetamineDRD2 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 protein]20340177
D008694Methamphetamine[gabapentin binds to and results in decreased activity of CACNA2D1 protein] which results in decreased susceptibility to Methamphetamine20340177
D008694Methamphetaminegabapentin inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]21182903
D008694MethamphetamineMethamphetamine results in increased expression of CACNA2D1 mRNA20340177|2118290
D008694MethamphetamineMethamphetamine results in increased expression of CACNA2D1 protein20340177
D008694MethamphetamineSCH 23390 inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]20340177
D008694MethamphetamineSCH 23390 inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 protein]20340177
D008694MethamphetamineSulpiride inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]20340177
D008694MethamphetamineSulpiride inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 protein]20340177
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CACNA2D1 mRNA20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CACNA2D1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CACNA2D1 mRNA"25554681
D009538NicotineNicotine results in increased expression of CACNA2D1 protein11756415
D009585Nitrogen Dioxide[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of CACNA2D1 gene28843141
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CACNA2D1 mRNA25607892
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CACNA2D1 mRNA25607892
C030110oxaliplatinoxaliplatin results in increased expression of CACNA2D1 mRNA19336915
D017239PaclitaxelPaclitaxel results in increased expression of CACNA2D1 mRNA16687474|1933691
D017239PaclitaxelPaclitaxel results in increased expression of CACNA2D1 protein16687474
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of CACNA2D1 mRNA26272509
C497431PD-0200347PD-0200347 binds to CACNA2D1 protein15693013
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CACNA2D1 mRNA26272509
D011189Potassium ChlorideCACNA2D1 protein affects the reaction [Potassium Chloride results in increased transport of Calcium]17881535
D011189Potassium Chloride[gabapentin binds to and results in decreased activity of CACNA2D1 protein] which results in decreased susceptibility to Potassium Chloride17881535
D011189Potassium Chloride[gabapentin results in decreased activity of CACNA2D1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]17442347
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of CACNA2D1 mRNA22714537
D000069583PregabalinCACNA2D1 affects the susceptibility to Pregabalin24269977
D000069583PregabalinCACNA2D1 gene mutant form results in decreased susceptibility to Pregabalin24133248
D000069583PregabalinCACNA2D1 protein affects the susceptibility to and affects the activity of Pregabalin17088553
D000069583PregabalinPregabalin binds to and affects the activity of CACNA2D1 protein24269977
D000069583PregabalinPregabalin binds to CACNA2D1 protein16460711
D000069583PregabalinPregabalin affects the localization of CACNA2D1 protein22949532
D000069583PregabalinPregabalin binds to and affects the activity of CACNA2D1 protein22949532
D000069583PregabalinPregabalin results in decreased expression of and affects the localization of CACNA2D1 protein19339603
D000069583PregabalinPregabalin results in decreased expression of CACNA2D1 mRNA19339603
D011374ProgesteroneProgesterone results in increased expression of CACNA2D1 mRNA22238285
D011374ProgesteroneProgesterone results in decreased expression of CACNA2D1 mRNA19690047
C502851quinocetonequinocetone results in increased expression of CACNA2D1 mRNA27046791
C059514resveratrolresveratrol results in decreased expression of CACNA2D1 mRNA22610192
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CACNA2D1 mRNA16054899
C534628SCH 23390SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]20340177
C534628SCH 23390SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 protein]20340177
D012834SilverSilver results in decreased expression of CACNA2D1 mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of CACNA2D1 mRNA21795629
C017947sodium arsenitesodium arsenite affects the expression of CACNA2D1 mRNA29319823
C017947sodium arsenitesodium arsenite results in increased expression of CACNA2D1 mRNA22714537
D012969Sodium FluorideSodium Fluoride results in decreased expression of CACNA2D1 mRNA21340527
C031618sodium nitratesodium nitrate results in increased expression of CACNA2D1 protein22687611
D013469SulpirideSulpiride inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]20340177
D013469SulpirideSulpiride inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 protein]20340177
D013629TamoxifenTamoxifen results in increased expression of CACNA2D1 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CACNA2D1 mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CACNA2D1 mRNA21354282
D013752TetracyclineTetracycline results in increased expression of CACNA2D1 mRNA16917069
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CACNA2D1 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of CACNA2D1 protein24648495
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of CACNA2D1 mRNA26272509
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of CACNA2D1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of CACNA2D1 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CACNA2D1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of CACNA2D1 mRNA23034163
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CACNA2D1 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of CACNA2D1 mRNA27188386
C111237vorinostatvorinostat results in increased expression of CACNA2D1 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005245voltage-gated calcium channel activity-IDA1309651  
GO:0005245voltage-gated calcium channel activitycontributes_toIDA11160515  17224476  
GO:0005245voltage-gated calcium channel activity-IGI21883149  
GO:0046872metal ion binding-IEA-  
GO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potentialcontributes_toIC17224476  
GO:0086057voltage-gated calcium channel activity involved in bundle of His cell action potentialcontributes_toIMP21383000  
GO ID GO Term Qualifier Evidence PubMed
GO:0006816calcium ion transport-IDA1309651  11160515  
GO:0051924regulation of calcium ion transport-IDA1309651  
GO:0060307regulation of ventricular cardiac muscle cell membrane repolarization-IMP25527503  
GO:0060402calcium ion transport into cytosol-ISS25527503  
GO:0061577calcium ion transmembrane transport via high voltage-gated calcium channel-ISS25527503  
GO:0086002cardiac muscle cell action potential involved in contraction-IMP25527503  
GO:0086048membrane depolarization during bundle of His cell action potential-IMP21383000  
GO:0086091regulation of heart rate by cardiac conduction-IMP25527503  
GO:0098703calcium ion import across plasma membrane-ISS-  
GO:0098903regulation of membrane repolarization during action potential-ISS25527503  
GO:1901843positive regulation of high voltage-gated calcium channel activity-ISS25527503  
GO:1902514regulation of calcium ion transmembrane transport via high voltage-gated calcium channel-IGI21883149  
GO:1904646cellular response to amyloid-beta-IGI21883149  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005891voltage-gated calcium channel complex-IDA11160515  17224476  
GO:0016529sarcoplasmic reticulum-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:1990454L-type voltage-gated calcium channel complex-IDA1309651  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04260Cardiac muscle contraction
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-112308Presynaptic depolarization and calcium channel openingTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-397014Muscle contractionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5576892Phase 0 - rapid depolarisationTAS
R-HSA-5576893Phase 2 - plateau phaseTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15846778Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. (2005 May 15)Worst TJJ Neurosci Res