Gene info: ID 7832

Gene: BTG2

GENE ID: 7832

Synonyms: APRO1|PC3|TIS21

Description: BTG anti-proliferation factor 2

Gene type: protein-coding

Location: 1q32.1

dbXrefs: Ensembl:ENSG00000159388 MIM:601597 Vega:OTTHUMG00000035834 UniprotKB:P78543

RefSeq: NG_046929.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.657e-1 (AD) 5.055e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FOS	0.859
SIK1	0.832
JUNB	0.831
DUSP1	0.817
ZFP36	0.813
CSRNP1	0.811
MCL1	0.778
APOLD1	0.771
FOXF1	0.753
CYR61	0.739

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.339
OR4F5	-0.305
HNF1A	-0.3
MKX	-0.298
MUM1L1	-0.298
GPR52	-0.295
CALHM1	-0.29
MYADML2	-0.289
KCNB2	-0.281
ANKRD34C	-0.277

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C012277	1,2-diamino-4-nitrobenzene	"1,2-diamino-4-nitrobenzene results in decreased expression of BTG2 mRNA"	17070881
C046760	15-acetyldeoxynivalenol	15-acetyldeoxynivalenol results in increased expression of BTG2 mRNA	23792671
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of BTG2 mRNA	28329830
C035314	1-nitropropane	1-nitropropane results in decreased expression of BTG2 mRNA	17070881
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BTG2 mRNA"	25614096
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of BTG2 mRNA"	21920950
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of BTG2 mRNA"	19114083
C573693	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in increased expression of BTG2 mRNA	22193206
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in increased expression of BTG2 mRNA"	20713471
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in increased expression of BTG2 mRNA"	17070881
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of BTG2 mRNA"	21346803
C025235	2,6-diaminotoluene	"2,6-diaminotoluene results in decreased expression of BTG2 mRNA"	17070881
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of BTG2 mRNA]	23196670
C014706	2-nitro-4-phenylenediamine	2-nitro-4-phenylenediamine results in decreased expression of BTG2 mRNA	17070881
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of BTG2 mRNA	14600272\|1589037
C016617	2-nitropropane	2-nitropropane results in increased expression of BTG2 mRNA	17070881
C054649	3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol	"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] which results in increased expression of BTG2 mRNA"	10821843
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of BTG2 mRNA"	20959002\|2319667
C026832	3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenz(a)anthracene	"3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenz(a)anthracene results in increased expression of BTG2 mRNA"	22236718
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of BTG2 mRNA	16788091
C026137	3-hydroxyacetanilide	3-hydroxyacetanilide results in increased expression of BTG2 mRNA	18544908
C473484	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine affects the expression of BTG2 mRNA	14610520
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BTG2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BTG2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BTG2 mRNA"	27188386
C028676	4-acetylaminofluorene	4-acetylaminofluorene results in decreased expression of BTG2 mRNA	17070881
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of BTG2 mRNA"	19561079
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BTG2 mRNA	14600272\|1589037
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide affects the expression of BTG2 mRNA	20829426
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BTG2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BTG2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BTG2 mRNA"	27188386
C000595015	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in increased expression of BTG2 mRNA"	28073004
D000082	Acetaminophen	Acetaminophen results in increased expression of BTG2 mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of BTG2 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in decreased expression of BTG2 mRNA	17585979
D000082	Acetaminophen	Acetaminophen results in increased expression of BTG2 mRNA	11264010\|1854490
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of BTG2 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of BTG2 mRNA]	17585979
D000082	Acetaminophen	Acetaminophen results in increased expression of BTG2 mRNA	15120968\|1720276
C106812	adefovir dipivoxil	adefovir dipivoxil results in increased expression of BTG2 mRNA	25596134
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of BTG2 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of BTG2 mRNA	21632981\|2164198
D016604	Aflatoxin B1	TP53 protein affects the reaction [Aflatoxin B1 results in increased expression of BTG2 mRNA]	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of BTG2 mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of BTG2 mRNA	14600272\|1589037
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of BTG2 mRNA	28522335
C077990	alvocidib	alvocidib results in increased expression of BTG2 mRNA	21382384
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of BTG2 mRNA	16483693
C006632	arsenic trioxide	arsenic trioxide results in increased expression of BTG2 mRNA	20458559\|2252195
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of BTG2 mRNA"	18687144
D001280	Atrazine	Atrazine results in increased expression of BTG2 mRNA	22378314
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of BTG2 mRNA	22236718
D001554	Benzene	Benzene results in decreased expression of BTG2 mRNA	15120971\|1512265
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of BTG2 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of BTG2 mRNA	21569818\|2196490
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of BTG2 mRNA"	20382639\|2623829
C038328	BEP protocol	BEP protocol results in increased expression of BTG2 mRNA	18987330
D004958	Estradiol	[Estradiol co-treated with EGF protein] results in decreased expression of BTG2 mRNA	24758408
D004958	Estradiol	Estradiol results in decreased expression of BTG2 mRNA	24758408
C095105	bexarotene	bexarotene results in decreased expression of BTG2 mRNA	16648578
C006780	bisphenol A	bisphenol A results in increased expression of BTG2 mRNA	27685785\|2927551
C006780	bisphenol A	bisphenol A results in increased methylation of BTG2 promoter	27312807
C006780	bisphenol A	bisphenol A results in increased expression of BTG2 mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of BTG2 mRNA	28628672
C546611	brevetoxin 2	brevetoxin 2 results in increased expression of BTG2 mRNA	20498034
C016274	bromoacetate	bromoacetate results in decreased expression of BTG2 mRNA	19753638
D002065	Buspirone	Buspirone results in decreased expression of BTG2 mRNA	24136188
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of BTG2 mRNA	12414654
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of BTG2 mRNA	21382384
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of BTG2 mRNA	25596134
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of BTG2 mRNA	24982889
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of BTG2 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of BTG2 mRNA	17522070
C010063	carbonyl sulfide	carbonyl sulfide results in increased expression of BTG2 mRNA	19395590
D002509	Cephaloridine	Cephaloridine results in decreased expression of BTG2 mRNA	18500788
C004656	chloroacetaldehyde	chloroacetaldehyde results in increased expression of BTG2 mRNA	25596134
D002725	Chloroform	Chloroform results in increased expression of BTG2 mRNA	9397189
D002725	Chloroform	Chloroform results in increased expression of BTG2 mRNA	17522070\|2181346
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BTG2 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of BTG2 mRNA	26272509
D002746	Chlorpromazine	Chlorpromazine analog results in increased expression of BTG2 mRNA	15924885
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of BTG2 mRNA	18668222
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of BTG2 gene	20938992
C022990	chromic chloride	chromic chloride results in increased expression of BTG2 mRNA	12128095
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of BTG2 mRNA	28472532
C059262	cidofovir	cidofovir results in increased expression of BTG2 mRNA	25596134
D004002	Clodronic Acid	Clodronic Acid results in increased expression of BTG2 mRNA	25596134
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of BTG2 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of BTG2 mRNA]	17585979
D002995	Clofibric Acid	Clofibric Acid affects the expression of BTG2 mRNA	17602206
C018021	cobaltous chloride	cobaltous chloride results in increased expression of BTG2 mRNA	16772336
D003042	Cocaine	Cocaine affects the expression of BTG2 mRNA	20187946
D003078	Colchicine	Colchicine results in decreased expression of BTG2 mRNA	24211769
D003345	Corticosterone	Corticosterone results in increased expression of BTG2 mRNA	15755911
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in decreased expression of BTG2 mRNA	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of BTG2 mRNA	19167446
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in decreased expression of BTG2 mRNA	21878529
D016572	Cyclosporine	Cyclosporine results in decreased expression of BTG2 mRNA	25596134
D016572	Cyclosporine	Cyclosporine results in decreased expression of BTG2 mRNA	25596134
D016572	Cyclosporine	Cyclosporine results in increased expression of BTG2 mRNA	21865292
D003561	Cytarabine	Cytarabine results in increased expression of BTG2 mRNA	21382384
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of BTG2 mRNA	24317228
C017185	delphinidin	delphinidin affects the expression of BTG2 mRNA	19182879
D003703	Demecolcine	Demecolcine results in increased expression of BTG2 mRNA	23649840
D003907	Dexamethasone	Dexamethasone results in increased expression of BTG2 mRNA	12782123
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of BTG2 mRNA	28628672
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of BTG2 mRNA	17361019\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of BTG2 mRNA	21266533\|2174549
D002945	Cisplatin	BTG2 protein affects the susceptibility to Cisplatin	16217747
D002945	Cisplatin	Cisplatin results in increased expression of BTG2 mRNA	19561079\|2153299
D002945	Cisplatin	Cisplatin results in increased expression of BTG2 protein	27358234
D002945	Cisplatin	Cisplatin results in increased expression of BTG2 mRNA	21382384\|2200319
D002945	Cisplatin	TRP53 protein affects the reaction [Cisplatin results in increased expression of BTG2 mRNA]	22003191
D002945	Cisplatin	Cisplatin results in increased expression of BTG2 mRNA	24880025
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in increased activity of BTG2 protein	27589886
D004006	Dichlorvos	Dichlorvos results in increased expression of BTG2 mRNA	21813463
D004041	Dietary Fats	Dietary Fats affects the expression of BTG2 mRNA	19680557
D004041	Dietary Fats	Dietary Fats results in increased expression of BTG2 mRNA	18042831
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of BTG2 mRNA	26033743
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of BTG2 mRNA	28085963
C014476	diethyl maleate	diethyl maleate results in decreased expression of BTG2 mRNA	25270620
C014476	diethyl maleate	diethyl maleate results in increased expression of BTG2 mRNA	22003191
C014476	diethyl maleate	NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]	22003191
C014476	diethyl maleate	TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]	22003191
D004052	Diethylnitrosamine	BTG2 protein results in decreased susceptibility to Diethylnitrosamine	18393292
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of BTG2 mRNA	18393292
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of BTG2 mRNA	19100860\|2160768
D004052	Diethylnitrosamine	Diethylnitrosamine affects the localization of and results in increased expression of BTG2 protein	19254457
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of BTG2 mRNA	19638242\|2181346
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of BTG2 mRNA	21382384
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of BTG2 mRNA	15890375
D002117	Calcitriol	Calcitriol results in decreased expression of BTG2 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of BTG2 mRNA	21592394
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of BTG2 mRNA"	22485181
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of BTG2 mRNA	14600272\|1589037
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of BTG2 mRNA	22193206
D004317	Doxorubicin	BTG2 results in increased susceptibility to Doxorubicin	18840609
D004317	Doxorubicin	Doxorubicin results in increased expression of BTG2	18840609
D004317	Doxorubicin	Doxorubicin results in increased expression of BTG2 mRNA	16705698
D004317	Doxorubicin	Doxorubicin results in increased expression of BTG2 mRNA	16243910\|2138238
D004317	Doxorubicin	Doxorubicin affects the expression of BTG2 mRNA	12187937
D004391	Dust	Dust results in increased expression of BTG2 mRNA	17805423
C479799	(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide	(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide results in increased expression of BTG2 mRNA	15528975
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of BTG2 mRNA	25187966
D004918	Erythromycin Estolate	Erythromycin Estolate results in increased expression of BTG2 mRNA	17522070
D000431	Ethanol	Ethanol results in decreased expression of BTG2 mRNA	15353170
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BTG2 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of BTG2 mRNA	12655037\|1755790
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of BTG2 mRNA	23550701
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of BTG2 mRNA	23649840
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased expression of BTG2 mRNA	19100860
D005047	Etoposide	Etoposide results in increased expression of BTG2 mRNA	24211769
D005047	Etoposide	Etoposide results in increased expression of BTG2 protein	27358234
D005047	Etoposide	TP53 promotes the reaction [Etoposide results in increased expression of BTG2 protein]	27358234
D005047	Etoposide	Etoposide results in increased expression of BTG2 mRNA	21382384\|2200319
D005047	Etoposide	TRP53 protein affects the reaction [Etoposide results in increased expression of BTG2 mRNA]	22003191
C540355	fenamidone	fenamidone results in increased expression of BTG2 mRNA	27029645
D011345	Fenofibrate	Fenofibrate affects the expression of BTG2 mRNA	25596134
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of BTG2 mRNA	28329830
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of BTG2 mRNA	21607683
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of BTG2 mRNA	17070881
D005472	Fluorouracil	Fluorouracil results in increased expression of BTG2 mRNA	17982676
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in increased expression of BTG2 mRNA]	15016801
D005472	Fluorouracil	TP53 protein promotes the reaction [Fluorouracil results in increased expression of BTG2 mRNA]	17982676
C061365	flusilazole	flusilazole results in decreased expression of BTG2 mRNA	28263823
D005485	Flutamide	Flutamide results in decreased expression of BTG2 mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of BTG2 gene	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of BTG2 mRNA	17938736\|2364984
D019833	Genistein	Genistein results in decreased expression of BTG2 mRNA	16705744
D005839	Gentamicins	Gentamicins results in increased expression of BTG2 mRNA	22061828
D005897	Glafenine	Glafenine results in increased expression of BTG2 mRNA	24136188
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of BTG2 mRNA	22634610
C004312	glycidol	glycidol results in decreased expression of BTG2 mRNA	24915197
C081021	Go 6976	[Tetradecanoylphorbol Acetate co-treated with Go 6976] results in increased expression of BTG2 mRNA	15302583
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of BTG2 mRNA	20044591
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of BTG2	18687144
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of BTG2 mRNA	12414654
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of BTG2 mRNA	21382384
C031927	hydroquinone	hydroquinone results in increased expression of BTG2 mRNA	23416264
D006918	Hydroxyurea	Hydroxyurea results in increased expression of BTG2 mRNA	24211769
C492448	ICG 001	ICG 001 results in increased expression of BTG2 mRNA	26191083
D007069	Ifosfamide	Ifosfamide results in increased expression of BTG2 mRNA	25596134
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of BTG2 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BTG2 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of BTG2 mRNA	28628672
C544151	jinfukang	jinfukang results in decreased expression of BTG2 mRNA	27392435
C098607	JP8 aviation fuel	JP8 aviation fuel results in increased expression of BTG2 protein	17337753
C008261	lead acetate	lead acetate results in decreased expression of BTG2 mRNA	22641619
C038753	leptomycin B	leptomycin B results in increased expression of BTG2 mRNA	20803015
C533894	LG 100815	LG 100815 results in increased expression of BTG2 mRNA	16951191
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of BTG2 mRNA	27339419
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of BTG2 mRNA	12057914
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of BTG2 mRNA	16401727
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of BTG2 mRNA	16415329
D008070	Lipopolysaccharides	Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of BTG2 mRNA]	16415329
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of BTG2 mRNA	21641980
D008558	Melphalan	Melphalan results in increased expression of BTG2 mRNA	22363485
C042720	mercuric bromide	mercuric bromide results in increased expression of BTG2 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BTG2 mRNA"	27188386
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of BTG2 mRNA	16507785
D008687	Metformin	Metformin affects the expression of BTG2 mRNA	25596134
D008694	Methamphetamine	Methamphetamine results in increased expression of BTG2 mRNA	19564919
D008701	Methapyrilene	Methapyrilene results in increased expression of BTG2 mRNA	15890375\|2181346
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of BTG2 gene	20938992
D008727	Methotrexate	BTG2 mRNA affects the susceptibility to Methotrexate	22753658
D008731	Methoxychlor	Methoxychlor affects the expression of BTG2 mRNA	20829426
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of BTG2 mRNA	22100608
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of BTG2 mRNA	23458150
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of BTG2 mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of BTG2 mRNA	22100608\|2364984
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of BTG2 mRNA	21382384\|2200319
D008741	Methyl Methanesulfonate	NFE2L2 protein affects the reaction [Methyl Methanesulfonate results in increased expression of BTG2 mRNA]	22003191
D008741	Methyl Methanesulfonate	TRP53 protein affects the reaction [Methyl Methanesulfonate results in increased expression of BTG2 mRNA]	22003191
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of BTG2 mRNA"	20188158
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in decreased expression of BTG2 protein	24821435
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of BTG2 mRNA	21382384
D016685	Mitomycin	Mitomycin results in increased expression of BTG2 mRNA	21382384\|2527062
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of BTG2 mRNA	16809437
D009151	Mustard Gas	Mustard Gas results in increased expression of BTG2 mRNA	15674843
C005246	myristicin	myristicin results in decreased expression of BTG2 mRNA	24792648
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of BTG2 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of BTG2 mRNA"	25620056
D009281	Naphthalenes	Naphthalenes results in increased expression of BTG2 protein	17337753
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of BTG2 mRNA	17522070
D009532	Nickel	Nickel results in increased expression of BTG2 mRNA	12540486
C022838	nickel chloride	nickel chloride results in increased expression of BTG2 mRNA	23566959\|2855277
C022838	nickel chloride	TP53 protein affects the reaction [nickel chloride results in increased expression of BTG2 mRNA]	23566959
D009538	Nicotine	Nicotine results in increased expression of BTG2 mRNA	17456735
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of BTG2 mRNA	17616710
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of BTG2 mRNA	19716841
C062198	octa-2,4,6-trienoic acid	"octa-2,4,6-trienoic acid results in increased expression of BTG2 mRNA"	16951191
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of BTG2 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in decreased expression of BTG2 mRNA	25596134
D017239	Paclitaxel	Paclitaxel results in decreased expression of BTG2 mRNA	15585946
D000073878	Palm Oil	Palm Oil affects the expression of BTG2 mRNA	19680557
D000073878	Palm Oil	Palm Oil results in increased expression of BTG2 mRNA	18042831
C016030	pantogab	pantogab results in increased expression of BTG2 mRNA	17379144
D010269	Paraquat	Paraquat results in increased expression of BTG2 mRNA	12595580
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of BTG2 mRNA	18593933
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in increased expression of BTG2 mRNA	17616710
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of BTG2 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital affects the expression of BTG2 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of BTG2 mRNA	19270015
D010634	Phenobarbital	Phenobarbital results in increased expression of BTG2 mRNA	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of BTG2 mRNA	19162173
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BTG2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of BTG2 mRNA	26272509
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of BTG2 mRNA	15890375
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of BTG2 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of BTG2 mRNA	18445702
C006253	pirinixic acid	pirinixic acid results in decreased expression of BTG2 mRNA	15890375
C006253	pirinixic acid	pirinixic acid results in increased expression of BTG2 mRNA	19162173
D010936	Plant Extracts	Plant Extracts results in increased expression of BTG2 mRNA	28533734
D011223	Praziquantel	Praziquantel results in increased expression of BTG2 mRNA	21813463
D011374	Progesterone	Progesterone results in increased expression of BTG2 mRNA	20726854
C005556	propionaldehyde	propionaldehyde results in increased expression of BTG2 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of BTG2 mRNA	24780913
C010313	pseudocumene	pseudocumene results in increased expression of BTG2 protein	17337753
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of BTG2 mRNA	27029645
C031280	pyrazole	pyrazole results in increased expression of BTG2 mRNA	17945193
D011794	Quercetin	Quercetin results in increased expression of BTG2 mRNA	21632981
C005266	quinomethionate	quinomethionate affects the expression of BTG2 mRNA	15387888
D011899	Ranitidine	[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of BTG2 mRNA	16401727
D011899	Ranitidine	Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of BTG2 mRNA]	16415329
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in decreased expression of BTG2 mRNA	19167446
C488333	Ro 65-7199	Ro 65-7199 affects the expression of BTG2 mRNA	14610520
C541923	sandostatinLAR	sandostatinLAR results in increased expression of BTG2 mRNA	17210224
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of BTG2 mRNA	22300531
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of BTG2 mRNA	19073995\|2322117
C009277	sodium arsenate	sodium arsenate results in increased expression of BTG2 mRNA	23922661
C017947	sodium arsenite	NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of BTG2 mRNA]	22003191
C017947	sodium arsenite	sodium arsenite results in increased expression of BTG2 mRNA	22003191
C017947	sodium arsenite	TRP53 protein affects the reaction [sodium arsenite results in increased expression of BTG2 mRNA]	22003191
C016104	sodium bichromate	sodium bichromate results in increased expression of BTG2 mRNA	24612858
C016104	sodium bichromate	sodium bichromate results in increased expression of BTG2 mRNA	25993096
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of BTG2 mRNA	27862939
D018038	Sodium Selenite	Sodium Selenite results in increased expression of BTG2 mRNA	24383545
D012999	Soman	Soman results in increased expression of BTG2 mRNA	19281266
D053260	Soot	Soot results in increased expression of BTG2 mRNA	26551751
C525423	SRT2183	SRT2183 results in increased expression of BTG2 mRNA	23681230
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of BTG2 mRNA	21641980
C016766	sulforafan	sulforafan results in increased expression of BTG2 mRNA	26833863
D016559	Tacrolimus	Tacrolimus results in increased expression of BTG2 mRNA	21865292
C061133	tamibarotene	tamibarotene results in increased expression of BTG2 mRNA	15498508
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of BTG2 mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of BTG2 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of BTG2 mRNA	16611356
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BTG2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of BTG2 mRNA	16962184\|1869160
D013749	Tetrachlorodibenzodioxin	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of BTG2 mRNA]	23196670
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of BTG2 mRNA	20959002\|2121527
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of BTG2 mRNA	28973375
D013752	Tetracycline	Tetracycline results in increased expression of BTG2 mRNA	17522070
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Go 6976] results in increased expression of BTG2 mRNA	15302583
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BTG2 mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in increased expression of BTG2 mRNA	23411599
C009495	titanium dioxide	titanium dioxide results in increased expression of BTG2 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of BTG2 mRNA	28111298
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of BTG2 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of BTG2 mRNA	25729387
C483909	torcetrapib	torcetrapib results in increased expression of BTG2 mRNA	23228038
D014212	Tretinoin	BTG2 protein affects the susceptibility to Tretinoin	16782888
D014212	Tretinoin	Tretinoin affects the localization of BTG2 protein	16782888
D014212	Tretinoin	Tretinoin inhibits the reaction [BTG2 protein binds to RARA protein]	16782888
D014212	Tretinoin	Tretinoin results in increased expression of BTG2 mRNA	15498508\|1678288
D014212	Tretinoin	Tretinoin results in increased expression of BTG2 protein	16782888
D014212	Tretinoin	Tretinoin results in decreased expression of BTG2 mRNA	20488242
C012589	trichostatin A	trichostatin A affects the expression of BTG2 mRNA	28542535
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BTG2 mRNA"	26179874
C022884	undecane	undecane results in increased expression of BTG2 protein	17337753
D014635	Valproic Acid	Valproic Acid results in decreased expression of BTG2 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in decreased expression of BTG2 mRNA	25596134
C066075	vanadium pentoxide	vanadium pentoxide results in decreased expression of BTG2 mRNA	17459161
D014640	Vancomycin	Vancomycin results in increased expression of BTG2 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of BTG2 mRNA	23940539
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of BTG2 gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of BTG2 mRNA	19165385
C025643	vinclozolin	vinclozolin affects the expression of BTG2 mRNA	19015723
D014750	Vincristine	Vincristine results in increased expression of BTG2 mRNA	23649840
C029297	vinylidene chloride	vinylidene chloride results in increased expression of BTG2 mRNA	26682919
D014801	Vitamin A	Vitamin A results in increased expression of BTG2 mRNA	17234770
D000225	Adenine	Adenine results in decreased expression of BTG2 mRNA	24211769
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of BTG2 mRNA	12414654
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of BTG2 mRNA	21382384
D015215	Zidovudine	Zidovudine results in increased expression of BTG2 mRNA	23675285
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of BTG2 mRNA	18593933
C088658	zoledronic acid	zoledronic acid results in decreased expression of BTG2 mRNA	25596134
C088658	zoledronic acid	zoledronic acid results in increased expression of BTG2 mRNA	20977926

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0005515	protein binding	-	IPI	9712883 11136725 18337750 21172304 25416956

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0006281	DNA repair	-	TAS	8944033
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006479	protein methylation	-	IEA	-
GO:0006974	cellular response to DNA damage stimulus	-	IDA	8944033
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	-	TAS	-
GO:0008285	negative regulation of cell proliferation	-	IBA	21873635
GO:0008285	negative regulation of cell proliferation	-	IMP	23236473
GO:0008306	associative learning	-	IEA	-
GO:0009612	response to mechanical stimulus	-	IEA	-
GO:0009952	anterior/posterior pattern specification	-	IEA	-
GO:0014070	response to organic cyclic compound	-	IEA	-
GO:0017148	negative regulation of translation	-	IDA	23236473
GO:0021542	dentate gyrus development	-	IEA	-
GO:0021954	central nervous system neuron development	-	IEA	-
GO:0031175	neuron projection development	-	IMP	18773938
GO:0035914	skeletal muscle cell differentiation	-	IEA	-
GO:0043434	response to peptide hormone	-	IEA	-
GO:0043524	negative regulation of neuron apoptotic process	-	IEA	-
GO:0045930	negative regulation of mitotic cell cycle	-	IBA	21873635
GO:0051602	response to electrical stimulus	-	IEA	-
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	-	IDA	18337750
GO:2000178	negative regulation of neural precursor cell proliferation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005829	cytosol	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term
hsa03018	RNA degradation

Reactome ID	Reactome Term	Evidence
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	TAS
R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24780075	Association of BTG2, CYR61, ZFP36, and SCD gene polymorphisms with Graves' disease and ophthalmopathy. (2014 Jul)	Planck T	Thyroid