Gene: PXDN

7837
ASGD7|COPOA|D2S448|D2S448E|MG50|PRG2|PXN|VPO
peroxidasin
protein-coding
2p25.3
Ensembl:ENSG00000130508 MIM:605158 Vega:OTTHUMG00000059697 UniprotKB:Q92626
NG_034221.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.708e-1 (AD)  6.325e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01328473chr2:1711966PXDN2.300e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LENG80.79
MYO190.789
SETD50.768
DNAH10.764
ZNF7830.76
CDRT40.757
TNRC6A0.756
AGAP60.754
RANBP100.752
WDR900.752

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.368
OR4F29-0.33
OBP2A-0.25
TRDN-0.243
DIAPH3-0.224
KLRC2-0.222
IRX3-0.204
CARD17-0.202
FOLR1-0.194
PAGE4-0.19

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of PXDN mRNA28329830
C5736932-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in decreased expression of PXDN mRNA22193206
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of PXDN mRNA"20406850
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PXDN mRNA"25380136
C006632arsenic trioxidearsenic trioxide results in decreased expression of PXDN mRNA15761015
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PXDN mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PXDN mRNA22300585
D004958EstradiolEstradiol affects the expression of PXDN mRNA22574217
C006780bisphenol Abisphenol A results in increased expression of PXDN mRNA26063408
C006780bisphenol Abisphenol A affects the expression of PXDN mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PXDN mRNA27339419
C026690cerous chloride[cerous chloride co-treated with lanthanum chloride] results in decreased expression of PXDN mRNA28954213
C026690cerous chloridecerous chloride results in decreased expression of PXDN mRNA28954213
C100187chloropicrinchloropicrin results in decreased expression of PXDN mRNA28476498
C039671ciglitazoneciglitazone results in decreased expression of PXDN mRNA22193206
D002994ClofibrateClofibrate results in decreased expression of PXDN mRNA22300585
C018021cobaltous chloridecobaltous chloride results in decreased secretion of PXDN protein22079246
C029892cupric chloridecupric chloride results in decreased expression of PXDN mRNA24650576
C014347decitabine[decitabine co-treated with vorinostat] affects the expression of PXDN mRNA17330099
D003907DexamethasoneDexamethasone results in decreased expression of PXDN mRNA22733784
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PXDN mRNA27392435
D002945CisplatinCisplatin results in increased expression of PXDN mRNA27392435
D002945CisplatinPXDN protein affects the susceptibility to Cisplatin16217747
D002945CisplatinCisplatin results in decreased expression of PXDN mRNA22023808
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PXDN mRNA26924002
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PXDN mRNA19638242
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of PXDN mRNA22193206
D004237DiuronDiuron results in increased expression of PXDN mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PXDN mRNA26865667
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of PXDN mRNA23649840
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of PXDN mRNA28329830
D005485FlutamideFlutamide results in decreased expression of PXDN mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of PXDN mRNA23649840
C039281furanfuran results in increased expression of PXDN mRNA27387713
D019833GenisteinGenistein results in decreased expression of PXDN mRNA26865667
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of PXDN mRNA22634610
D017313FenretinideFenretinide results in decreased expression of PXDN mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of PXDN mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PXDN mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PXDN mRNA26752646
C028521lanthanum chloride[cerous chloride co-treated with lanthanum chloride] results in decreased expression of PXDN mRNA28954213
C028521lanthanum chloridelanthanum chloride results in decreased expression of PXDN mRNA28954213
D008154LucanthoneLucanthone results in increased expression of PXDN mRNA21148553
D008628MercuryMercury results in decreased expression of PXDN mRNA19937285
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PXDN mRNA23649840
D015735MifepristoneMifepristone results in decreased expression of PXDN mRNA25972201
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PXDN mRNA26924002
C523799MRK 003MRK 003 results in decreased expression of PXDN mRNA21169257
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PXDN mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PXDN mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of PXDN mRNA25380136
C030110oxaliplatinoxaliplatin results in increased expression of PXDN mRNA16510598
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PXDN mRNA25729387
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of PXDN mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of PXDN mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of PXDN mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of PXDN mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of PXDN mRNA]17655762
D010100OxygenOxygen deficiency results in increased expression of PXDN mRNA24492474
D010100OxygenOxygen deficiency results in increased expression of PXDN protein24492474
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of PXDN mRNA]24492474
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of PXDN protein]24492474
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of PXDN mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of PXDN mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of PXDN mRNA]17655762
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PXDN mRNA22714537
C005556propionaldehydepropionaldehyde results in increased expression of PXDN mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of PXDN mRNA24780913
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of PXDN mRNA]24492474
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of PXDN protein]24492474
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PXDN mRNA23806026
C004648testosterone enanthatetestosterone enanthate affects the expression of PXDN mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PXDN mRNA20055451
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PXDN mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PXDN mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PXDN mRNA26232522
C009495titanium dioxidetitanium dioxide results in decreased expression of PXDN mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PXDN mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PXDN mRNA25729387
C057693troglitazonetroglitazone results in decreased expression of PXDN mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of PXDN mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of PXDN gene29154799
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of PXDN mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of PXDN mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of PXDN mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PXDN gene25560391
C025643vinclozolinvinclozolin affects the expression of PXDN mRNA19015723
D014810Vitamin EVitamin E results in decreased expression of PXDN mRNA19244175
C111237vorinostat[decitabine co-treated with vorinostat] affects the expression of PXDN mRNA17330099

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004601peroxidase activity-IBA21873635  
GO:0004601peroxidase activity-IDA18929642  19590037  
GO:0004601peroxidase activity-TAS-  
GO:0005152interleukin-1 receptor antagonist activity-NAS11103812  
GO:0005201extracellular matrix structural constituent-IDA19590037  
GO:0020037heme binding-IDA18929642  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001960negative regulation of cytokine-mediated signaling pathway-IEA-  
GO:0006955immune response-NAS11103812  
GO:0006979response to oxidative stress-IEA-  
GO:0030198extracellular matrix organization-IDA19590037  
GO:0042744hydrogen peroxide catabolic process-IDA18929642  
GO:0055114oxidation-reduction process-IDA18929642  
GO:0098869cellular oxidant detoxification-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA18929642  
GO:0005783endoplasmic reticulum-IDA19590037  
GO:0031012extracellular matrix-IDA19590037  
GO:0062023collagen-containing extracellular matrix-HDA23979707  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474290Collagen formationTAS
R-HSA-2022090Assembly of collagen fibrils and other multimeric structuresTAS
R-HSA-2243919Crosslinking of collagen fibrilsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29455858A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. (2018 Mar 1)Sung YJAm J Hum Genet