Gene: PAX8

7849
-
paired box 8
protein-coding
2q14.1
Ensembl:ENSG00000125618 MIM:167415 Vega:OTTHUMG00000128529 UniprotKB:Q06710
NG_012384.1
PubMed
0   ANCO-SNPs
ND
2   
5.501e-1 (AD)  5.659e-1 (ND)   (Frontal_Cortex)
3.838e-1 (AD)  9.550e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FOXE10.551
IYD0.548
TPO0.544
KRT70.538
DIO10.531
TG0.525
TSHR0.524
SLC26A70.497
TFF30.496
WDR720.49

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IFNA1-0.222
C20orf141-0.208
CPA6-0.207
STRA8-0.206
LINC00348-0.185
BHLHA15-0.183
REN-0.173
KPNA7-0.173
TAAR9-0.17
APOA4-0.166

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of PAX8 mRNA25088246
D000082AcetaminophenAcetaminophen results in decreased expression of PAX8 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of PAX8 mRNA29067470
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PAX8 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in increased expression of PAX8 mRNA12558987
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PAX8 mRNA24449571
C028559bathocuproine sulfonatebathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased expression of PAX8 mRNA]11108245
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to PAX8 promoter]19654925
C006780bisphenol Abisphenol A results in increased expression of PAX8 mRNA23238275
C006780bisphenol Abisphenol A results in increased expression of PAX8 mRNA23238275
C006780bisphenol Abisphenol A results in decreased expression of PAX8 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of PAX8 mRNA23238275|2682790
C006780bisphenol Abisphenol A results in increased expression of PAX8 protein23238275
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of PAX8 promoter22457795
D002118CalciumCalcium affects the expression of PAX8 mRNA15913539
D002330CarmustineCarmustine results in decreased expression of PAX8 mRNA15980968
D003042CocaineCocaine results in increased expression of PAX8 mRNA12629581
D005576ColforsinColforsin results in increased expression of PAX8 mRNA15961562
D005576ColforsinColforsin results in increased expression of PAX8 protein15961562
D005576ColforsinColforsin results in increased expression of PAX8 mRNA16837620
D003314Corn OilCorn Oil affects the expression of PAX8 mRNA16360708
D016578Crack CocaineCrack Cocaine results in decreased expression of PAX8 mRNA12629581
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PAX8 mRNA23914054
C014347decitabine[decitabine co-treated with Tretinoin] results in increased expression of PAX8 mRNA19524134
D003994BucladesineBucladesine results in increased expression of PAX8 mRNA16837620
D002945CisplatinPAX8 protein affects the susceptibility to Cisplatin16217747
D005411Flame RetardantsFlame Retardants results in increased expression of PAX8 mRNA19945756
D005419FlavonoidsFlavonoids results in decreased expression of PAX8 mRNA18035473
C039281furanfuran results in increased expression of PAX8 mRNA25539665
C010176halofuginonehalofuginone results in decreased expression of PAX8 mRNA17180598
D007854LeadLead results in decreased expression of PAX8 mRNA19921347
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PAX8 mRNA12057914
D008627Mercuric ChlorideMercuric Chloride affects the expression of PAX8 mRNA20353558
D009538NicotineNicotine results in increased expression of PAX8 mRNA23825647
D009538NicotineNicotine results in decreased expression of PAX8 mRNA26776438
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of PAX8 mRNA19945756
C539348perfluorobutanesulfonic acidperfluorobutanesulfonic acid affects the expression of PAX8 mRNA22071372
C033094perfluorobutyric acidperfluorobutyric acid results in increased expression of PAX8 mRNA22071372
C522391perfluorododecanoic acidperfluorododecanoic acid results in increased expression of PAX8 mRNA22071372
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of PAX8 mRNA22071372
C479228perfluorohexanoic acidperfluorohexanoic acid results in increased expression of PAX8 mRNA22071372
C584865perfluorononanoic acidperfluorononanoic acid results in increased expression of PAX8 mRNA22071372
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PAX8 mRNA21184528
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of PAX8 mRNA18407306|2307402
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of PAX8 mRNA22071372
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PAX8 mRNA23399300
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PAX8 mRNA22071372
C586085perfluoroundecanoic acidperfluoroundecanoic acid results in increased expression of PAX8 mRNA22071372
D010936Plant ExtractsPlant Extracts results in decreased expression of PAX8 mRNA23557933
C020972pyrrolidine dithiocarbamic acidbathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased expression of PAX8 mRNA]11108245
C020972pyrrolidine dithiocarbamic acidPAX8 protein inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased activity of TPO promoter]11108245
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid results in decreased chemical synthesis of PAX8 protein11108245
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid results in decreased expression of PAX8 mRNA11108245
D011794QuercetinQuercetin results in decreased expression of PAX8 mRNA15309432
C059514resveratrolNOTCH1 mutant form inhibits the reaction [resveratrol results in increased expression of PAX8 mRNA]23594881
C059514resveratrolresveratrol results in increased expression of PAX8 mRNA23594881
C059514resveratrolresveratrol results in increased expression of PAX8 protein23594881
C059514resveratrolresveratrol results in decreased expression of PAX8 mRNA28668442
D020123SirolimusSirolimus promotes the reaction [TP73 protein affects the activity of PAX8 protein]21245298
C009361sulisobenzonesulisobenzone results in increased expression of PAX8 mRNA20937294
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PAX8 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PAX8 mRNA24058054
D014212Tretinoin[decitabine co-treated with Tretinoin] results in increased expression of PAX8 mRNA19524134
D014212TretinoinTretinoin results in decreased expression of PAX8 mRNA21924320
D014212TretinoinTretinoin results in increased expression of PAX8 mRNA16979153
D014520UrethaneUrethane results in decreased expression of PAX8 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of PAX8 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA9388203  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003677DNA binding-IDA8861958  15961562  
GO:0003677DNA binding-IMP9590296  
GO:0003700DNA-binding transcription factor activity-IDA9388203  9590296  
GO:0004996thyroid-stimulating hormone receptor activity-TAS9590296  
GO:0005515protein binding-IPI19010321  20195357  
GO:0044212transcription regulatory region DNA binding-IDA15356023  
GO ID GO Term Qualifier Evidence PubMed
GO:0001655urogenital system development-ISS-  
GO:0001658branching involved in ureteric bud morphogenesis-IEP1337742  
GO:0001822kidney development-IEP15494458  
GO:0001823mesonephros development-ISS-  
GO:0003281ventricular septum development-IEA-  
GO:0003337mesenchymal to epithelial transition involved in metanephros morphogenesis-IEP8861958  
GO:0006351transcription, DNA-templated-IDA9590296  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006790sulfur compound metabolic process-IEA-  
GO:0007417central nervous system development-IEP15494458  
GO:0009653anatomical structure morphogenesis-TAS9590296  
GO:0010667negative regulation of cardiac muscle cell apoptotic process-IEA-  
GO:0030878thyroid gland development-IEP1337742  15494458  
GO:0030878thyroid gland development-IMP9590296  
GO:0038194thyroid-stimulating hormone signaling pathway-IEA-  
GO:0039003pronephric field specification-ISS-  
GO:0042472inner ear morphogenesis-ISS-  
GO:0042981regulation of apoptotic process-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-IDA9388203  15356023  15961562  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA9388203  
GO:0048793pronephros development-ISS-  
GO:0071371cellular response to gonadotropin stimulus-IDA15961562  
GO:0071599otic vesicle development-IEP15494458  
GO:0072108positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis-ISS-  
GO:0072207metanephric epithelium development-IEP7856737  
GO:0072221metanephric distal convoluted tubule development-ISS-  
GO:0072278metanephric comma-shaped body morphogenesis-IEP1337742  
GO:0072284metanephric S-shaped body morphogenesis-IEP1337742  
GO:0072289metanephric nephron tubule formation-ISS-  
GO:0072305negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis-ISS-  
GO:0072307regulation of metanephric nephron tubule epithelial cell differentiation-ISS-  
GO:0090190positive regulation of branching involved in ureteric bud morphogenesis-ISS-  
GO:1900212negative regulation of mesenchymal cell apoptotic process involved in metanephros development-ISS-  
GO:1900215negative regulation of apoptotic process involved in metanephric collecting duct development-ISS-  
GO:1900218negative regulation of apoptotic process involved in metanephric nephron tubule development-ISS-  
GO:2000594positive regulation of metanephric DCT cell differentiation-ISS-  
GO:2000611positive regulation of thyroid hormone generation-IMP15356023  
GO:2000612regulation of thyroid-stimulating hormone secretion-IMP15356023  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA9388203  15961562  21317881  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-ISS-  
KEGG ID KEGG Term
hsa05200Pathways in cancer
hsa05216Thyroid cancer
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24342438Prior appendectomy does not protect against subsequent development of malignant or borderline mucinous ovarian neoplasms. (2014 Feb)Elias KMGynecol Oncol
28339471Expression quantitative trait loci for PAX8 contributes to the prognosis of hepatocellular carcinoma. (2017)Ma SPLoS One