Gene info: ID 7850

Gene: IL1R2

GENE ID: 7850

Description: interleukin 1 receptor type 2

Gene type: protein-coding

Location: 2q11.2

dbXrefs: Ensembl:ENSG00000115590 MIM:147811 Vega:OTTHUMG00000130695 UniprotKB:P27930

RefSeq: NC_000002.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.571e-1 (AD) 3.754e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LILRA5	0.826
VNN2	0.765
APOBEC3A	0.735
S100A12	0.727
FFAR2	0.715
CXCR1	0.715
SELL	0.708
MMP25	0.708
IL18RAP	0.707
NFE2	0.704

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NEUROD6	-0.509
EXTL1	-0.503
MAGIX	-0.495
KCNIP3	-0.485
SLC32A1	-0.482
CHRNA4	-0.475
RCOR2	-0.474
SCRT1	-0.472
MARCH4	-0.468
ABCC12	-0.46

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C063609	1,2-dimethyl-4-nitrobenzene	"1,2-dimethyl-4-nitrobenzene results in decreased expression of IL1R2 mRNA"	19784758
C490166	1-(4-methoxyphenyl)piperazine	1-(4-methoxyphenyl)piperazine results in increased expression of IL1R2 mRNA	26821219
C078092	1-piperonylpiperazine	1-piperonylpiperazine results in increased expression of IL1R2 mRNA	26821219
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of IL1R2 mRNA"	23146750
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide results in decreased expression of IL1R2 protein	11031321\|1142861
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of IL1R2 mRNA"	18648102
C496492	abrine	abrine results in increased expression of IL1R2 mRNA	22595364
D000082	Acetaminophen	Acetaminophen results in decreased expression of IL1R2 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of IL1R2 mRNA	17562736
D000082	Acetaminophen	Acetaminophen affects the expression of IL1R2 mRNA	17984051\|1978475
D000082	Acetaminophen	Acetaminophen results in decreased expression of IL1R2 mRNA	19784758
D000082	Acetaminophen	Acetaminophen results in increased expression of IL1R2 mRNA	19784758
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of IL1R2 mRNA	21641981
C430898	AGN 194204	AGN 194204 results in decreased expression of IL1R2 mRNA	16339527
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of IL1R2 mRNA	16483693
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of IL1R2 mRNA"	22863853
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of IL1R2 mRNA	24449571
D001151	Arsenic	Arsenic affects the expression of IL1R2 mRNA	19654921
C006632	arsenic trioxide	arsenic trioxide results in increased expression of IL1R2 mRNA	21461292
C015001	arsenite	arsenite affects the expression of IL1R2 mRNA	22959463
D001241	Aspirin	IL1R2 affects the susceptibility to Aspirin	19489917
D001554	Benzene	Benzene results in increased expression of IL1R2 mRNA	19162166
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of IL1R2 mRNA	26377693
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of IL1R2 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of IL1R2 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of IL1R2 mRNA	21569818
C038682	benzyl bromide	benzyl bromide results in increased expression of IL1R2 mRNA	20713136
D004958	Estradiol	Estradiol results in increased expression of IL1R2 mRNA	23019147
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of IL1R2 mRNA	19693291
D004958	Estradiol	Estradiol results in increased expression of IL1R2 mRNA	12469912\|1969329
C006780	bisphenol A	bisphenol A results in increased methylation of IL1R2 gene	28505145
C047757	butyl bromide	butyl bromide results in increased expression of IL1R2 mRNA	20713136
D002104	Cadmium	[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of IL1R2 mRNA	21481475
C028031	cadmium acetate	cadmium acetate affects the expression of IL1R2 mRNA	16249259
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of IL1R2 promoter	22457795
D000069287	Capecitabine	IL1R2 protein results in increased susceptibility to Capecitabine	16734730
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of IL1R2 mRNA	12734012
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of IL1R2 mRNA	19784758
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IL1R2 mRNA	20938992
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of IL1R2 mRNA	19376846
D016572	Cyclosporine	Cyclosporine results in decreased expression of IL1R2 mRNA	20106945\|2556210
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of IL1R2 mRNA	24921660
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of IL1R2 mRNA	23914054
C014347	decitabine	decitabine inhibits the reaction [Smoke results in decreased expression of IL1R2 mRNA]	21095227
D003907	Dexamethasone	Dexamethasone results in increased expression of IL1R2 mRNA	21041162
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of IL1R2 mRNA	21266533
D004008	Diclofenac	Diclofenac results in increased expression of IL1R2 mRNA	26934552
C000944	dicrotophos	dicrotophos results in decreased expression of IL1R2 mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in decreased expression of IL1R2 mRNA	18042831
D004041	Dietary Fats	Dietary Fats results in increased expression of IL1R2 mRNA	18721800
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of IL1R2 mRNA	26033743
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of IL1R2 mRNA	21527772
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of IL1R2 mRNA	15171707\|2104116
D002117	Calcitriol	Calcitriol results in decreased expression of IL1R2 mRNA	26485663
C472511	dimethylarsinous acid	dimethylarsinous acid results in increased expression of IL1R2 mRNA	16507463
D000069347	Erlotinib Hydrochloride	[Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which affects the expression of IL1R2 mRNA	27738319
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of IL1R2 mRNA	23649840
D005054	Eugenol	Eugenol results in increased expression of IL1R2 mRNA	20713136
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IL1R2 mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of IL1R2 mRNA	23649840
D005620	Freund's Adjuvant	Freund's Adjuvant results in decreased expression of IL1R2 mRNA	20846436
C039281	furan	furan results in increased expression of IL1R2 mRNA	27387713
D019833	Genistein	Genistein results in increased expression of IL1R2 mRNA	23019147
D005944	Glucosamine	[IL1B protein co-treated with Glucosamine] results in increased expression of IL1R2 mRNA	11801247
D005976	Glutaral	Glutaral results in increased expression of IL1R2 mRNA	20713136
D017313	Fenretinide	Fenretinide results in increased expression of IL1R2 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of IL1R2 mRNA	20044591
D007213	Indomethacin	Indomethacin results in increased expression of IL1R2 mRNA	11950807
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL1R2 mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of IL1R2 mRNA	26752646
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of IL1R2 mRNA	21045076
D008294	Malathion	Malathion results in decreased expression of IL1R2 mRNA	19784758
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IL1R2 mRNA	20938992
D008727	Methotrexate	Methotrexate results in decreased expression of IL1R2 mRNA	17400583
D008727	Methotrexate	Methotrexate results in increased expression of IL1R2 mRNA	21678067
D008727	Methotrexate	Methotrexate affects the expression of IL1R2 mRNA	18502557
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of IL1R2 mRNA	23649840
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of IL1R2 mRNA	16507463
C500085	muraglitazar	muraglitazar results in decreased expression of IL1R2 mRNA	21515302
D009151	Mustard Gas	Mustard Gas results in increased expression of IL1R2 mRNA	25102026
D009173	Mycophenolic Acid	Mycophenolic Acid results in increased expression of IL1R2 mRNA	19818335
D009183	Mycotoxins	Mycotoxins results in increased expression of IL1R2 mRNA	19818335
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of IL1R2 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of IL1R2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of IL1R2 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of IL1R2 mRNA"	19836432
C461488	N-benzylpiperazine	N-benzylpiperazine results in increased expression of IL1R2 mRNA	26821219
C015380	neoechinulin	neoechinulin results in decreased expression of IL1R2 mRNA	19818335
D009532	Nickel	Nickel results in increased expression of IL1R2 mRNA	25583101
C029938	nickel sulfate	nickel sulfate results in increased expression of IL1R2 mRNA	16780908
C029938	nickel sulfate	nickel sulfate results in increased expression of IL1R2 mRNA	16166746
D009578	Nitrobenzenes	Nitrobenzenes analog results in decreased expression of IL1R2 mRNA	19784758
C025589	ochratoxin A	ochratoxin A results in increased expression of IL1R2 mRNA	22124623
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of IL1R2 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of IL1R2 mRNA	25729387
D010126	Ozone	Ozone results in increased expression of IL1R2 mRNA	14754758\|1746015
D010126	Ozone	Ozone results in increased expression of IL1R2 mRNA	28623178
D000073878	Palm Oil	Palm Oil results in decreased expression of IL1R2 mRNA	18042831
D052638	Particulate Matter	Particulate Matter results in increased expression of IL1R2 mRNA	28341207
D010634	Phenobarbital	Phenobarbital affects the expression of IL1R2 mRNA	19159669
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IL1R2 mRNA	19710929
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of IL1R2 mRNA	19693291
D011791	Quartz	Quartz results in increased expression of IL1R2 mRNA	19836432
D011794	Quercetin	Quercetin results in decreased expression of IL1R2 mRNA	21632981
D015474	Isotretinoin	Isotretinoin results in decreased expression of IL1R2 mRNA	20436886
C089730	rosiglitazone	rosiglitazone results in decreased expression of IL1R2 mRNA	21515302
D012643	Selenium	[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of IL1R2 mRNA	21481475
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of IL1R2 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of IL1R2 mRNA	23221170
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of IL1R2 mRNA	22431001
D012834	Silver	Silver affects the expression of IL1R2 mRNA	27131904
D019821	Simvastatin	Simvastatin results in decreased expression of IL1R2 mRNA	16414398
D012906	Smoke	decitabine inhibits the reaction [Smoke results in decreased expression of IL1R2 mRNA]	21095227
C017947	sodium arsenite	sodium arsenite results in increased expression of IL1R2 mRNA	12760830\|1650746
C017947	sodium arsenite	sodium arsenite results in decreased expression of IL1R2 mRNA	21911445
D012999	Soman	Soman results in increased expression of IL1R2 mRNA	19281266
D053260	Soot	Soot results in increased expression of IL1R2 mRNA	22461453\|2655175
C501413	tesaglitazar	tesaglitazar results in decreased expression of IL1R2 mRNA	21515302
D013739	Testosterone	Testosterone results in increased expression of IL1R2 mRNA	19693291
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of IL1R2 mRNA	25461914
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IL1R2 mRNA	11489354\|2010694
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of IL1R2 mRNA	26377647
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IL1R2 mRNA	16120747\|1703548
D013755	Tetradecanoylphorbol Acetate	SOD2 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1R2 mRNA]	21045076
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of IL1R2 mRNA	21045076
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL1R2 mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in decreased expression of IL1R2 mRNA	19784758
C009495	titanium dioxide	titanium dioxide results in increased expression of IL1R2 mRNA	21259345\|2355797
C402696	TMC 120A	TMC 120A results in increased expression of IL1R2 mRNA	19818335
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of IL1R2 mRNA	27404394
D014028	Tobacco Smoke Pollution	NFE2L2 protein inhibits the reaction [Tobacco Smoke Pollution affects the expression of IL1R2 mRNA]	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of IL1R2 mRNA	20133372
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of IL1R2 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of IL1R2 mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of IL1R2 mRNA"	19682533
C057693	troglitazone	troglitazone results in decreased expression of IL1R2 mRNA	25572481
C057693	troglitazone	troglitazone results in increased expression of IL1R2 mRNA	28973697
C057693	troglitazone	troglitazone results in decreased expression of IL1R2 mRNA	21515302
D014520	Urethane	Urethane results in decreased expression of IL1R2 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased methylation of IL1R2 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of IL1R2 mRNA	28001369\|2915479
C034028	vanadyl sulfate	vanadyl sulfate results in increased expression of IL1R2 mRNA	16217019
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of IL1R2 gene	25560391
D015032	Zinc	IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of IL1R2 mRNA]	18316168
D015032	Zinc	MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of IL1R2 mRNA]	18316168
D015032	Zinc	Zinc results in decreased expression of IL1R2 mRNA	18316168
C031238	zinc sulfide	[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of IL1R2 mRNA	21481475
C088658	zoledronic acid	zoledronic acid results in decreased expression of IL1R2 mRNA	24714768
D015054	Zymosan	Zymosan results in increased expression of IL1R2 protein	15550091

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004908	interleukin-1 receptor activity	-	TAS	10191101
GO:0004910	interleukin-1, type II, blocking receptor activity	-	IEA	-
GO:0005515	protein binding	-	IPI	1830582 16971486 25241761
GO:0019966	interleukin-1 binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006955	immune response	-	TAS	8898719
GO:0010955	negative regulation of protein processing	-	IEA	-
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0050712	negative regulation of interleukin-1 alpha secretion	-	IEA	-
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	-
GO:1900016	negative regulation of cytokine production involved in inflammatory response	-	IEA	-
GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IEA	-
GO:0005737	cytoplasm	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0016021	integral component of membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04640	Hematopoietic cell lineage
hsa05146	Amoebiasis

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-168256	Immune System	TAS
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-6783783	Interleukin-10 signaling	TAS
R-HSA-9020702	Interleukin-1 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19948975	Integrative predictive model of coronary artery calcification in atherosclerosis. (2009 Dec 15)	McGeachie M	Circulation
24818754	Interleukin-1 receptor gene variants are associated with aggressive periodontitis in the Japanese. (2014 Jul)	Kamei H	Arch Oral Biol