Gene: CXCR4

7852
CD184|D2S201E|FB22|HM89|HSY3RR|LAP-3|LAP3|LCR1|LESTR|NPY3R|NPYR|NPYRL|NPYY3R|WHIM|WHIMS
C-X-C motif chemokine receptor 4
protein-coding
2q22.1
Ensembl:ENSG00000121966 MIM:162643 Vega:OTTHUMG00000153583 UniprotKB:P61073
NG_011587.1
PubMed
ND|AD
18   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.884e-3 (AD)  5.535e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYTIP0.677
GPR1830.677
OSM0.662
TMEM510.646
C5AR10.642
RGS10.635
CCRL20.625
SAT10.613
SERTAD30.602
RUNX30.599

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPEF1-0.372
PAX7-0.364
GRIN2B-0.362
SERF1B-0.362
GJD4-0.361
AARD-0.359
NDST3-0.357
KCNB2-0.356
OR2W3-0.353
TDRD5-0.347

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00452FramycetinSmall Molecule119-04-0ApprovedTarget
DB05501AMD-070Small MoleculeInvestigationalTarget
DB06809PlerixaforSmall Molecule110078-46-1ApprovedTarget
DB12698IbalizumabBiotechDrug680188-33-4Approved|InvestigationalTarget
ID Drug Name Action PubMed
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of CXCR4 mRNA23792671
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased expression of CXCR4 mRNA]25827057
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of CXCR4 mRNA"19095052
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"CXCR4 protein results in decreased susceptibility to 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"22549810
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CXCR4 mRNA"19114083
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of CXCR4 mRNA"25710175
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of CXCR4 mRNA"25710175
C0261142-xylene2-xylene results in increased expression of CXCR4 mRNA20359517
C0163923,3'-diindolylmethane"3,3'-diindolylmethane affects the methylation of CXCR4 promoter"24466240
C0163923,3'-diindolylmethane"3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of CXCR4 protein]"28844962
C0163923,3'-diindolylmethane"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of CXCR4 protein]"28844962
C0163923,3'-diindolylmethane"3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of CXCR4 protein]"28844962
C0888604-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Colforsin results in increased expression of CXCR4 mRNA]"24784705
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of CXCR4 mRNA19191707
C0297284-phenylenediamine4-phenylenediamine results in decreased expression of CXCR4 protein15924226
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
C0776467,12-benz(a)anthraquinone"7,12-benz(a)anthraquinone results in increased expression of CXCR4 mRNA"26141390
C496492abrineabrine results in increased expression of CXCR4 mRNA22595364
D000181AcrylonitrileAcrylonitrile results in decreased expression of CXCR4 mRNA16173056
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CXCR4 mRNA28458013
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CXCR4 mRNA28943387
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CXCR4 gene28458013
D016604Aflatoxin B1decitabine inhibits the reaction [Aflatoxin B1 results in decreased expression of CXCR4 mRNA]28458013
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CXCR4 mRNA28789997
C000188alachloralachlor results in increased expression of CXCR4 mRNA12419858
D000447AldehydesAldehydes results in increased expression of CXCR4 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CXCR4 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CXCR4 mRNA24449571|2533912
C004984apocarotenalapocarotenal results in increased expression of CXCR4 mRNA17034753
D034341Aristolochic AcidsAristolochic Acids results in increased expression of CXCR4 mRNA19717638
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of CXCR4 mRNA18585445
D001151ArsenicArsenic affects the expression of CXCR4 protein24675094
C006632arsenic trioxidearsenic trioxide affects the expression of CXCR4 mRNA20458559
C006632arsenic trioxidearsenic trioxide inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 protein]25047463
C006632arsenic trioxidearsenic trioxide inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 mRNA]25047463
C006632arsenic trioxidearsenic trioxide inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 protein]25047463
C006632arsenic trioxidearsenic trioxide results in decreased expression of CXCR4 mRNA25047463|2670570
C006632arsenic trioxidearsenic trioxide results in decreased expression of CXCR4 protein25047463
C006632arsenic trioxidePPP2CA protein affects the reaction [arsenic trioxide results in decreased expression of CXCR4 protein]25047463
C006632arsenic trioxideRELA protein inhibits the reaction [arsenic trioxide inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 protein]]25047463
C006632arsenic trioxideRELA protein inhibits the reaction [arsenic trioxide results in decreased expression of CXCR4 protein]25047463
C015001arsenitearsenite results in decreased expression of CXCR4 mRNA18191166
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of CXCR4 mRNA18585445
D001379AzathioprineAzathioprine results in decreased expression of CXCR4 mRNA19192274
C051597Bandrowski's baseBandrowski's base affects the expression of CXCR4 mRNA18202158
D001548Benzalkonium CompoundsBenzalkonium Compounds results in increased expression of CXCR4 mRNA20713136
C012768benzanthronebenzanthrone results in increased expression of CXCR4 mRNA26141390
D001554BenzeneBenzene results in increased expression of CXCR4 mRNA20359517
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite affects the expression of CXCR4 mRNA26314263
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CXCR4 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CXCR4 protein20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CXCR4 mRNA21569818
C038682benzyl bromidebenzyl bromide results in increased expression of CXCR4 mRNA20713136
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TPD7 compound results in decreased expression of CXCR4 protein]25753200
D019207beta Carotenebeta Carotene results in increased expression of CXCR4 mRNA17034753
D004958Estradiol"3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of CXCR4 protein]"28844962
D004958EstradiolCXCR4 protein results in decreased susceptibility to Estradiol22549810
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of CXCR4 mRNA]24758408
D004958Estradiol[Estradiol co-treated with EGF protein] results in increased expression of CXCR4 mRNA24758408
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of CXCR4 mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CXCR4 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of CXCR4 mRNA19619570|2475840
D004958EstradiolEstradiol results in increased expression of CXCR4 protein28844962
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of CXCR4 protein]28844962
D004958EstradiolJM 3100 inhibits the reaction [Estradiol results in increased expression of CXCR4 protein]28844962
D004958EstradiolEstradiol results in increased expression of CXCR4 protein17578864
C006780bisphenol A"3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of CXCR4 protein]"28844962
C006780bisphenol Abisphenol A results in increased expression of CXCR4 protein28844962
C006780bisphenol ACXCR4 protein results in decreased susceptibility to bisphenol A22549810
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in increased expression of CXCR4 protein]28844962
C006780bisphenol AJM 3100 inhibits the reaction [bisphenol A results in increased expression of CXCR4 protein]28844962
C006780bisphenol Abisphenol A results in increased expression of CXCR4 mRNA27178563
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of CXCR4 mRNA26314263
D000069286BortezomibBortezomib results in decreased expression of CXCR4 mRNA20977926
D002038Bungarotoxins[Mecamylamine co-treated with Dihydro-beta-Erythroidine co-treated with Bungarotoxins] inhibits the reaction [Nicotine results in increased expression of CXCR4 protein]20457658
D019328Buthionine SulfoximineButhionine Sulfoximine results in decreased expression of CXCR4 mRNA15878706
D020122tert-Butylhydroperoxide[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CXCR4 mRNA20847119
D020122tert-Butylhydroperoxide[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CXCR4 mRNA20847119
D020122tert-Butylhydroperoxiderosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CXCR4 mRNA]20847119
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide promotes the reaction [PPARG protein binds to CXCR4 promoter]20847119
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of CXCR4 mRNA20847119
D020122tert-Butylhydroperoxide[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CXCR4 mRNA20847119
D020122tert-Butylhydroperoxidetroglitazone inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [PPARG protein binds to CXCR4 promoter]]20847119
D020122tert-Butylhydroperoxidetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CXCR4 mRNA]20847119
C018475butyraldehydebutyraldehyde results in increased expression of CXCR4 mRNA26079696
D002104Cadmium[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of CXCR4 mRNA21481475
D002104CadmiumCadmium results in increased expression of CXCR4 mRNA22562489|2262661
D002104CadmiumCadmium results in increased expression of CXCR4 protein22626610
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CXCR4 mRNA12634122
C034939cadmium sulfide[cadmium telluride co-treated with cadmium sulfide] results in decreased expression of CXCR4 mRNA20596552
C028337cadmium telluride[cadmium telluride co-treated with cadmium sulfide] results in decreased expression of CXCR4 mRNA20596552
D002118CalciumCXCR4 protein affects the abundance of Calcium12055238
D002211CapsaicinCapsaicin results in increased expression of CXCR4 protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein]22150557
D002251Carbon Tetrachloride1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased expression of CXCR4 mRNA]25827057
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CXCR4 mRNA25827057
D002251Carbon Tetrachloride[2-Acetylaminofluorene co-treated with Carbon Tetrachloride] results in increased expression of CXCR4 protein12626097
D007631ChlordeconeChlordecone results in increased expression of CXCR4 protein17578864
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of CXCR4 mRNA18636392
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of CXCR4 mRNA26272509
D002737ChloropreneChloroprene results in decreased expression of CXCR4 mRNA23125180
C023676chloroquine diphosphatechloroquine diphosphate results in decreased expression of CXCR4 mRNA19192274
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CXCR4 mRNA20938992
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CXCR4 mRNA12634122
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of CXCR4 mRNA17382205
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CXCR4 mRNA12634122
C012843cinnamic aldehydecinnamic aldehyde results in decreased expression of CXCR4 mRNA28219650
D002994ClofibrateClofibrate results in decreased expression of CXCR4 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of CXCR4 mRNA24784705
C018021cobaltous chloridecobaltous chloride results in increased expression of CXCR4 mRNA26314263
C018021cobaltous chloridecobaltous chloride results in increased expression of CXCR4 protein25815440
C018021cobaltous chlorideresveratrol inhibits the reaction [cobaltous chloride results in increased expression of CXCR4 protein]25815440
D003042CocaineCocaine results in increased expression of CXCR4 protein16204638
D005576Colforsin"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Colforsin results in increased expression of CXCR4 mRNA]"24784705
D005576ColforsinColforsin results in increased expression of CXCR4 mRNA24784705
D005576ColforsinMifepristone inhibits the reaction [Colforsin results in increased expression of CXCR4 mRNA]24784705
D005576ColforsinN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of CXCR4 mRNA]24784705
D005576ColforsinU 0126 inhibits the reaction [Colforsin results in increased expression of CXCR4 mRNA]24784705
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of CXCR4 mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of CXCR4 mRNA19549813
D003436Croton OilCroton Oil results in increased expression of CXCR4 mRNA19647056
C540323CTCE-9908CTCE-9908 binds to and results in decreased activity of CXCR4 protein21905730
D003471CuprizoneCuprizone results in increased expression of CXCR4 mRNA26577399
D003474CurcuminCurcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA]18660423
D003474CurcuminCurcumin results in decreased expression of CXCR4 mRNA17198877
D003474CurcuminCurcumin results in decreased expression of CXCR418462866
D003520CyclophosphamideCyclophosphamide results in decreased expression of CXCR4 mRNA21041162
D003520CyclophosphamideCyclophosphamide affects the localization of CXCR4 protein19066630
D003520CyclophosphamideCyclophosphamide promotes the reaction [MIF protein binds to CXCR4 protein]19066630
D003520CyclophosphamideCyclophosphamide results in increased expression of CXCR4 mRNA19066630|2003211
D003520CyclophosphamideCyclophosphamide results in increased expression of CXCR4 protein20032115
C496951cyclo(tyrosyl-arginyl-arginyl-3-(2-naphthyl)alanyl-glycyl)cyclo(tyrosyl-arginyl-arginyl-3-(2-naphthyl)alanyl-glycyl) binds to CXCR4 protein21905730
C089595cylindrospermopsincylindrospermopsin results in increased expression of CXCR4 mRNA24921660
D003561CytarabineCytarabine results in increased expression of CXCR4 mRNA19194470|2119855
D003622DapsoneDapsone analog inhibits the reaction [Metribolone results in increased expression of CXCR4 mRNA]21440447
D003630DaunorubicinDaunorubicin results in decreased expression of CXCR4 mRNA27090888
D016047ZalcitabineZalcitabine results in increased expression of CXCR4 mRNA17292584
C014347decitabinedecitabine affects the expression of CXCR4 mRNA17145863
C014347decitabine[decitabine affects the methylation of CXCR4 promoter] which affects the expression of CXCR4 mRNA18320071|1832007
C014347decitabine[decitabine co-treated with trichostatin A] results in increased expression of CXCR4 mRNA17616702
C014347decitabinedecitabine inhibits the reaction [Aflatoxin B1 results in decreased expression of CXCR4 mRNA]28458013
C107676deguelindeguelin inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 mRNA]22745725
C007262deoxynivalenoldeoxynivalenol results in increased expression of CXCR4 mRNA22846391|2775749
D003907DexamethasoneDexamethasone inhibits the reaction [TNF protein results in increased expression of CXCR4 mRNA]21420233
D003907DexamethasoneDexamethasone results in increased expression of CXCR4 mRNA11872090|1273228
D003907DexamethasoneDexamethasone results in increased expression of CXCR4 protein11872090
D003907DexamethasoneDexamethasone results in decreased expression of CXCR4 mRNA21041162|2273378
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in increased expression of CXCR4 mRNA20705681
D002945Cisplatin[Cisplatin co-treated with panobinostat] affects the expression of CXCR4 mRNA21791302
D002945CisplatinCisplatin results in increased expression of CXCR4 mRNA27594783
D004008DiclofenacDiclofenac results in decreased expression of CXCR4 mRNA19192274
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CXCR4 mRNA21041162
D004079Dihydro-beta-Erythroidine[Mecamylamine co-treated with Dihydro-beta-Erythroidine co-treated with Bungarotoxins] inhibits the reaction [Nicotine results in increased expression of CXCR4 protein]20457658
D002117CalcitriolCalcitriol results in increased expression of CXCR4 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of CXCR4 mRNA21592394
C012125diisononyl phthalatediisononyl phthalate results in increased expression of CXCR4 protein20064775
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of CXCR4 mRNA19371601
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of CXCR4 mRNA17374397|2014638
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of CXCR4 mRNA28219650
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of CXCR4 mRNA19647056
D004139DinitrofluorobenzeneDinitrofluorobenzene results in decreased expression of CXCR4 protein15924226
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of CXCR4 mRNA28939011
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of CXCR4 mRNA24690739
D004237DiuronDiuron results in increased expression of CXCR4 mRNA25152437
D004317DoxorubicinDoxorubicin results in increased expression of CXCR4 mRNA27181935
D004317DoxorubicinFungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of CXCR4 mRNA]27181935
D004391DustDust results in decreased expression of CXCR4 mRNA17805423
C118739entinostatentinostat results in decreased expression of CXCR4 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
D004917ErythromycinErythromycin results in increased expression of CXCR4 protein19502290
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CXCR4 mRNA17351261
C004912ethylbenzeneethylbenzene results in increased expression of CXCR4 mRNA20359517
D017308EtodolacEtodolac results in decreased expression of CXCR4 protein16046235
D005054EugenolEugenol results in increased expression of CXCR4 mRNA20713136
C000499ferric oxideferric oxide analog results in increased expression of CXCR4 mRNA25086211
D005419FlavonoidsFlavonoids results in decreased expression of CXCR4 mRNA18035473
D0150732-Acetylaminofluorene[2-Acetylaminofluorene co-treated with Carbon Tetrachloride] results in increased expression of CXCR4 protein12626097
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of CXCR4 mRNA15579440
D005472FluorouracilFluorouracil affects the expression of CXCR4 mRNA16584549
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CXCR4 mRNA20938992
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in increased expression of CXCR4 protein]28844962
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of CXCR4 protein]28844962
C070081fulvestrantfulvestrant inhibits the reaction [Triclosan results in increased expression of CXCR4 protein]28844962
C056933fumonisin B1fumonisin B1 results in decreased expression of CXCR4 mRNA27757495
D062610Fungal PolysaccharidesFungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of CXCR4 mRNA]27181935
C039281furanfuran results in increased expression of CXCR4 mRNA27387713
D005707Gallic AcidGallic Acid inhibits the reaction [TNF protein results in increased expression of CXCR4 mRNA]21420233
C056507gemcitabinegemcitabine affects the expression of CXCR4 mRNA20103597
D019833GenisteinCXCR4 protein results in decreased susceptibility to Genistein22549810
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of CXCR4 mRNA21782745
D005947Glucose[Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCR4 mRNA18227068
D005947Glucose[Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCR4 protein18227068
D005947GlucoseGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] promotes the reaction [HIF1A protein binds to CXCR4 promoter]]18227068
D005947GlucoseGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCR4 mRNA]18227068
D005947GlucoseGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCR4 protein]18227068
D005947Glucose[Glucose co-treated with Oxygen deficiency] inhibits the reaction [HIF1A protein binds to CXCR4 promoter]18227068
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of CXCR4 mRNA22634610
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in decreased expression of CXCR4 mRNA19192274
D006493HeparinHeparin analog results in decreased expression of CXCR4 mRNA20201787
D006493HeparinHeparin analog results in decreased expression of CXCR4 protein20201787
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of CXCR4 mRNA15159207
D017313FenretinideFenretinide results in decreased expression of CXCR4 mRNA28973697
D017313FenretinideFenretinide results in increased expression of CXCR4 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CXCR4 mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CXCR4 mRNA25613284
C088327JM 3100JM 3100 binds to and results in decreased activity of CXCR4 protein12220670
C088327JM 3100JM 3100 inhibits the reaction [bisphenol A results in increased expression of CXCR4 protein]28844962
C088327JM 3100JM 3100 inhibits the reaction [CXCL12 protein affects the localization of CXCR4 protein]12220670
C088327JM 3100JM 3100 inhibits the reaction [Estradiol results in increased expression of CXCR4 protein]28844962
C088327JM 3100JM 3100 inhibits the reaction [Triclosan results in increased expression of CXCR4 protein]28844962
C088327JM 3100JM 3100 results in decreased activity of CXCR4 protein17121897
C088327JM 3100JM 3100 results in decreased expression of CXCR4 protein28844962
C088327JM 3100JM 3100 binds to and results in decreased activity of CXCR4 protein17292584
C088327JM 3100JM 3100 results in decreased activity of CXCR4 protein16005638|1866042
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of CXCR4 protein19726579
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CXCR4 mRNA22802445|2308692
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CXCR4 mRNA12634122
C008261lead acetatelead acetate affects the expression of CXCR4 mRNA21829687
C533894LG 100815LG 100815 results in increased expression of CXCR4 mRNA16951191
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CXCR4 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CXCR4 mRNA25890327|2658214
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CXCR4 protein15924226
C501277Mangifera indica extractMangifera indica extract inhibits the reaction [TNF protein results in increased expression of CXCR4 mRNA]21420233
C013592mangiferinmangiferin inhibits the reaction [TNF protein results in increased expression of CXCR4 mRNA]21420233
D008464Mecamylamine[Mecamylamine co-treated with Dihydro-beta-Erythroidine co-treated with Bungarotoxins] inhibits the reaction [Nicotine results in increased expression of CXCR4 protein]20457658
D008466MechlorethamineMechlorethamine results in increased expression of CXCR4 mRNA17107856
C042720mercuric bromidemercuric bromide results in decreased expression of CXCR4 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CXCR4 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of CXCR4 mRNA19192274
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of CXCR4 mRNA21782745
D008752Methylene ChlorideMethylene Chloride results in increased expression of CXCR4 mRNA20359517
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CXCR4 mRNA26272509|2800136
C030957methylmercury IImethylmercury II results in increased expression of CXCR4 mRNA26314263
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CXCR4 mRNA23649840
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of CXCR4 mRNA12634122
D008775MethylprednisoloneMethylprednisolone results in decreased expression of CXCR4 mRNA19192274
D008777MethyltestosteroneMethyltestosterone results in decreased expression of CXCR4 mRNA29191790
D015741MetriboloneDapsone analog inhibits the reaction [Metribolone results in increased expression of CXCR4 mRNA]21440447
D015741MetriboloneMetribolone results in increased expression of CXCR4 mRNA21440447
D015735MifepristoneMifepristone inhibits the reaction [Colforsin results in increased expression of CXCR4 mRNA]24784705
D015735MifepristoneMifepristone results in decreased expression of CXCR4 mRNA25972201
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of CXCR4 mRNA22108045
D009151Mustard GasMustard Gas results in increased expression of CXCR4 mRNA18988085
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of CXCR4 mRNA]24784705
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CXCR4 mRNA"25554681
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein]22150557
D009532NickelNickel results in increased expression of CXCR4 mRNA24768652|2558310
D009532NickelNickel analog results in decreased expression of CXCR4 mRNA25144474
C029938nickel sulfatenickel sulfate affects the expression of CXCR4 mRNA18202158
C029938nickel sulfatenickel sulfate results in increased expression of CXCR4 mRNA16780908|1737439
C029938nickel sulfatenickel sulfate results in decreased expression of CXCR4 protein15924226
D009538Nicotine[Mecamylamine co-treated with Dihydro-beta-Erythroidine co-treated with Bungarotoxins] inhibits the reaction [Nicotine results in increased expression of CXCR4 protein]20457658
D009538NicotineNicotine results in increased expression of CXCR4 mRNA20457658
D009538NicotineNicotine results in increased expression of CXCR4 protein20457658
D009569Nitric OxideNitric Oxide deficiency results in decreased expression of CXCR4 mRNA15878706
C510003nordynordy inhibits the reaction [CXCR4 protein results in increased expression of CXCL8 protein]17415525
C510003nordynordy inhibits the reaction [CXCR4 protein results in increased expression of VEGFA protein]17415525
C510003nordynordy results in decreased expression of CXCR4 protein17415525
C025589ochratoxin Aochratoxin A metabolite results in decreased expression of CXCR4 mRNA26314263
C025589ochratoxin Aochratoxin A results in decreased expression of CXCR4 mRNA26314263
C025589ochratoxin Aochratoxin A results in increased expression of CXCR4 mRNA19717638
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of CXCR4 mRNA"16951191
C021065oleandrinoleandrin results in increased expression of CXCR4 mRNA24172227
D009853OmeprazoleAHR protein affects the reaction [Omeprazole results in decreased expression of CXCR4 mRNA]25826687
D009853OmeprazoleOmeprazole results in decreased expression of CXCR4 mRNA25826687
D010081OxazoloneOxazolone results in increased expression of CXCR4 mRNA17374397
D010081OxazoloneOxazolone results in decreased expression of CXCR4 mRNA11379042
D010100Oxygenarsenic trioxide inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 mRNA]25047463
D010100Oxygenarsenic trioxide inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 protein]25047463
D010100Oxygendeguelin inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 mRNA]22745725
D010100OxygenOxygen deficiency results in increased expression of CXCR4 mRNA17476338|1751782
D010100OxygenOxygen deficiency results in increased expression of CXCR4 protein17476338|2504746
D010100Oxygen[Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCR4 mRNA18227068
D010100Oxygen[Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCR4 protein18227068
D010100OxygenOxygen deficiency results in increased expression of CXCR4 mRNA22745725|2647637
D010100OxygenOxygen deficiency results in increased expression of CXCR4 protein26476374
D010100OxygenQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 mRNA]26476374
D010100OxygenQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 protein]26476374
D010100OxygenGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] promotes the reaction [HIF1A protein binds to CXCR4 promoter]]18227068
D010100OxygenGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCR4 mRNA]18227068
D010100OxygenGLO1 protein inhibits the reaction [[Glucose co-treated with Oxygen deficiency] results in decreased expression of CXCR4 protein]18227068
D010100Oxygen[Glucose co-treated with Oxygen deficiency] inhibits the reaction [HIF1A protein binds to CXCR4 promoter]18227068
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of CXCR4 mRNA18636392
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in increased expression of CXCR4 mRNA20705681
D017239PaclitaxelCXCR4 mRNA results in decreased susceptibility to Paclitaxel16322897
C496932panobinostat[Cisplatin co-treated with panobinostat] affects the expression of CXCR4 mRNA21791302
D010269ParaquatParaquat results in decreased expression of CXCR4 mRNA18198484
D052638Particulate MatterParticulate Matter results in decreased expression of CXCR4 mRNA25144474
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of CXCR4 mRNA18593933
D010396PenicillaminePenicillamine results in decreased expression of CXCR4 mRNA19575532
D010396PenicillaminePenicillamine results in increased expression of CXCR4 mRNA19575532
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of CXCR4 mRNA19095052
C046012pentanalpentanal results in increased expression of CXCR4 mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CXCR4 mRNA18692542
D015232DinoprostoneDinoprostone results in increased expression of CXCR4 mRNA16303787
D015232DinoprostoneDinoprostone results in increased expression of CXCR4 protein16303787
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CXCR4 mRNA26272509
D010705PhosgenePhosgene affects the expression of CXCR4 mRNA16300373
D010852PicrotoxinPicrotoxin results in increased expression of CXCR4 mRNA15170462
C121565pifithrinpifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCR4 mRNA]20064835
C060836pioglitazone[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CXCR4 mRNA20847119
D010894PiroxicamPiroxicam results in decreased expression of CXCR4 mRNA19192274
D010938Plant OilsPlant Oils results in increased expression of CXCR4 mRNA23370395
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of CXCR4 mRNA17382205
D011239PrednisolonePrednisolone results in decreased expression of CXCR4 mRNA19192274
D011341ProbucolProbucol promotes the reaction [APOE gene mutant form results in increased expression of CXCR4 mRNA]19394937
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of CXCR4 mRNA20660070
D011374ProgesteroneProgesterone results in decreased expression of CXCR4 mRNA20726854
C005556propionaldehydepropionaldehyde results in increased expression of CXCR4 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of CXCR4 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of CXCR4 mRNA20596804
D011794QuercetinQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 mRNA]26476374
D011794QuercetinQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 protein]26476374
C059514resveratrolresveratrol inhibits the reaction [cobaltous chloride results in increased expression of CXCR4 protein]25815440
C059514resveratrolresveratrol results in decreased expression of CXCR4 mRNA15280659
C059514resveratrolresveratrol results in decreased expression of CXCR4 protein26959057
C059514resveratrolSIRT1 protein inhibits the reaction [resveratrol results in decreased expression of CXCR4 protein]26959057
C089730rosiglitazone[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CXCR4 mRNA20847119
C089730rosiglitazonerosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CXCR4 mRNA]20847119
D012524SarinSarin results in decreased expression of CXCR4 mRNA19522546
D012643Selenium[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of CXCR4 mRNA21481475
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of CXCR4 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide results in increased expression of CXCR4 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of CXCR4 mRNA19073995|2322117
D019821SimvastatinSimvastatin results in decreased expression of CXCR4 mRNA16414398
D019821SimvastatinSimvastatin results in increased expression of CXCR419591934
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CXCR4 mRNA12634122
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in increased expression of CXCR4 mRNA20713136
D019311StaurosporineStaurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of CXCR4 protein]12594210
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein]22150557
C061133tamibarotenetamibarotene results in increased uptake of and affects the localization of CXCR4 protein20141446
C061133tamibarotenetamibarotene results in decreased expression of CXCR4 mRNA20861477
D013629TamoxifenDNMT3B protein affects the reaction [Tamoxifen results in decreased expression of CXCR4 mRNA]19019622
D013629TamoxifenDNMT3B protein affects the reaction [Tamoxifen results in decreased expression of CXCR4 protein]19019622
D013629TamoxifenTamoxifen results in decreased expression of CXCR4 mRNA19019622
D013629TamoxifenTamoxifen results in decreased expression of CXCR4 protein19019622
D013629TamoxifenTamoxifen results in increased methylation of CXCR4 promoter19019622
D013629TamoxifenTamoxifen results in increased expression of CXCR4 mRNA25123088
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of CXCR4 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of CXCR4 mRNA21592394
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of CXCR4 mRNA20189893
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of CXCR4 mRNA25461914
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CXCR4 mRNA19619570
D013749Tetrachlorodibenzodioxinpifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCR4 mRNA]20064835
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CXCR4 mRNA17517823|1961957
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CXCR4 protein17517823
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CXCR4 mRNA12377990
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CXCR4 mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CXCR4 gene]20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CXCR4 mRNA20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CXCR4 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CXCR4 mRNA25613284
C020809tetrathiomolybdatetetrathiomolybdate analog results in increased expression of CXCR4 mRNA19323979
D013853ThioacetamideThioacetamide results in increased methylation of CXCR4 promoter27914986
C009495titanium dioxidetitanium dioxide results in increased expression of CXCR4 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CXCR4 mRNA25447457
D014050TolueneToluene results in increased expression of CXCR4 mRNA20359517
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of CXCR4 mRNA"11379042
D014118Toxins, Biological"Toxins, Biological affects the expression of CXCR4 mRNA"19682533
C000604982TPD7 compoundbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TPD7 compound results in decreased expression of CXCR4 protein]25753200
C000604982TPD7 compoundCXCR4 protein results in increased susceptibility to TPD7 compound25753200
C000604982TPD7 compoundTPD7 compound results in decreased expression of CXCR4 mRNA25753200
C000604982TPD7 compoundTPD7 compound results in decreased expression of CXCR4 protein25753200
C012293tranilasttranilast results in decreased expression of CXCR4 mRNA25826687
D014212TretinoinTretinoin results in decreased expression of CXCR4 mRNA23724009
C011559tributyltintributyltin results in increased expression of CXCR4 mRNA19371601|2631426
D014241TrichloroethyleneTrichloroethylene results in increased expression of CXCR4 mRNA20359517
C012589trichostatin A[decitabine co-treated with trichostatin A] results in increased expression of CXCR4 mRNA17616702
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CXCR4 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of CXCR4 mRNA24935251
D014260Triclosan"3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of CXCR4 protein]"28844962
D014260Triclosanfulvestrant inhibits the reaction [Triclosan results in increased expression of CXCR4 protein]28844962
D014260TriclosanJM 3100 inhibits the reaction [Triclosan results in increased expression of CXCR4 protein]28844962
D014260TriclosanTriclosan results in increased expression of CXCR4 protein28844962
C001899triptolidetriptolide results in decreased expression of CXCR4 protein26420756
C057693troglitazone[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CXCR4 mRNA20847119
C057693troglitazonetroglitazone inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [PPARG protein binds to CXCR4 promoter]]20847119
C057693troglitazonetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CXCR4 mRNA]20847119
C113580U 0126U 0126 inhibits the reaction [Colforsin results in increased expression of CXCR4 mRNA]24784705
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CXCR4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CXCR4 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of CXCR4 mRNA24935251
C025643vinclozolinvinclozolin affects the expression of CXCR4 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of CXCR4 mRNA18220299
C025643vinclozolinvinclozolin results in increased expression of CXCR4 mRNA20566332
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCR4 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of CXCR4 mRNA20145270|2627250
C111237vorinostatvorinostat results in decreased expression of CXCR4 protein20145270
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of CXCR4 mRNA18593933
D015032ZincZinc deficiency results in increased expression of CXCR4 mRNA22689922
C509592zinc(II) dipicolylaminezinc(II) dipicolylamine analog inhibits the reaction [CXCL12 protein binds to and results in increased activity of CXCR4 protein]16722661
C509592zinc(II) dipicolylaminezinc(II) dipicolylamine analog results in decreased activity of CXCR4 protein16722661
C031238zinc sulfide[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of CXCR4 mRNA21481475
C088658zoledronic acidzoledronic acid results in increased expression of CXCR4 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0003779actin binding-IDA12421915  
GO:0004930G-protein coupled receptor activity-TAS8276799  
GO:0005515protein binding-IPI10644702  12421915  15660419  17077324  18632580  18765807  
19106094  19665027  20215400  20802527  23773523  23926103  
24094005  
GO:0015026coreceptor activity-TAS10754293  
GO:0016493C-C chemokine receptor activity-IBA21873635  
GO:0016494C-X-C chemokine receptor activity-NAS9468539  
GO:0019956chemokine binding-IBA21873635  
GO:0019957C-C chemokine binding-IBA21873635  
GO:0019957C-C chemokine binding-IPI25612609  
GO:0031625ubiquitin protein ligase binding-IPI19116316  
GO:0032027myosin light chain binding-IDA12421915  
GO:0043130ubiquitin binding-IDA20228059  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-TAS10570282  
GO:0001666response to hypoxia-IEP15174142  
GO:0002407dendritic cell chemotaxis-TAS16621978  
GO:0006915apoptotic process-TAS10942389  
GO:0006935chemotaxis-IBA21873635  
GO:0006954inflammatory response-TAS8276799  
GO:0006955immune response-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-IDA10644702  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007204positive regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-TAS10228019  
GO:0007411axon guidance-TAS-  
GO:0007420brain development-IBA21873635  
GO:0009615response to virus-TAS10583963  
GO:0019064fusion of virus membrane with host plasma membrane-TAS-  
GO:0019722calcium-mediated signaling-IBA21873635  
GO:0019722calcium-mediated signaling-IMP19064997  
GO:0022008neurogenesis-IBA21873635  
GO:0030260entry into host cell-TAS-  
GO:0043217myelin maintenance-ISS-  
GO:0048714positive regulation of oligodendrocyte differentiation-ISS-  
GO:0050920regulation of chemotaxis-IMP19106094  
GO:0060326cell chemotaxis-IBA21873635  
GO:0070098chemokine-mediated signaling pathway-IEA-  
GO:0071345cellular response to cytokine stimulus-IDA21540189  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-TAS10415069  
GO:0005764lysosome-IDA21540189  
GO:0005764lysosomecolocalizes_withIDA24790097  
GO:0005769early endosome-IDA21540189  
GO:0005769early endosomecolocalizes_withIDA24790097  
GO:0005770late endosome-IDA21540189  
GO:0005886plasma membrane-IDA21540189  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0009986cell surface-IDA10521508  10644702  18308860  19106094  23620790  
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0031252cell leading edge-IDA12421915  
GO:0031410cytoplasmic vesicle-IDA10521508  19106094  
GO:0032991protein-containing complex-IMP25612609  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
hsa04144Endocytosis
hsa04360Axon guidance
hsa04670Leukocyte transendothelial migration
hsa04672Intestinal immune network for IgA production
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162587HIV Life CycleTAS
R-HSA-162594Early Phase of HIV Life CycleTAS
R-HSA-162906HIV InfectionTAS
R-HSA-1643685DiseaseTAS
R-HSA-173107Binding and entry of HIV virionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-376176Signaling by ROBO receptorsTAS
R-HSA-380108Chemokine receptors bind chemokinesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-5663205Infectious diseaseTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22688403Differential transcriptomic analysis of spontaneous lung tumors in B6C3F1 mice: comparison to human non-small cell lung cancer. (2012 Dec)Pandiri ARToxicol Pathol
25060794Stromal cell-derived factor 1 as a biomarker of heart failure and mortality risk. (2014 Sep)Subramanian SArterioscler Thromb Vasc Biol
25204042Detection of CD34/CXCR4+ stem cells in peripheral blood of patients following acute myocardial infarction. (2014)Abdallah KOEgypt J Immunol
24399233Angiogenic T cells are decreased in rheumatoid arthritis patients. (2015 May)Rodriguez-Carrio JAnn Rheum Dis
25834393Clinicopathological significance of CXCR4 in non-small cell lung cancer. (2015)Zhou XMDrug Des Devel Ther
20147779The role of chemokine receptor CXCR4 in lung cancer. (2010 Mar 15)Gangadhar TCancer Biol Ther
29514830Progenitor Cells and Clinical Outcomes in Patients With Acute Coronary Syndromes. (2018 May 25)Samman Tahhan ACirc Res
24155926HIV gp120 induces mucus formation in human bronchial epithelial cells through CXCR4/alpha7-nicotinic acetylcholine receptors. (2013)Gundavarapu SPLoS One
24486245Estrogen receptor beta and CXCR4/CXCL12 expression: differences by sex and hormonal status in lung adenocarcinoma. (2014 Feb)Rodriguez-Lara VArch Med Res
27595689Bone marrow cell characteristics associated with patient profile and cardiac performance outcomes in the LateTIME-Cardiovascular Cell Therapy Research Network (CCTRN) trial. (2016 Sep)Bhatnagar AAm Heart J
20457658Repetitive nicotine exposure leads to a more malignant and metastasis-prone phenotype of SCLC: a molecular insight into the importance of quitting smoking during treatment. (2010 Aug)Martinez-Garcia EToxicol Sci
27436845Age and Human Regenerative Capacity Impact of Cardiovascular Risk Factors. (2016 Sep 16)Al Mheid ICirc Res
21121937Alveolar macrophage gene expression is altered in the setting of alcohol use disorders. (2011 Feb)Burnham ELAlcohol Clin Exp Res
24808825CXCL12 chemokine and GABA neurotransmitter systems crosstalk and their putative roles. (2014)Guyon AFront Cell Neurosci
29324662Aryl Hydrocarbon Receptor Antagonists Mitigate the Effects of Dioxin on Critical Cellular Functions in Differentiating Human Osteoblast-Like Cells. (2018 Jan 11)Yun CInt J Mol Sci
28775206Clinical Molecular Imaging of Chemokine Receptor CXCR4 Expression in Atherosclerotic Plaque Using (68)Ga-Pentixafor PET: Correlation with Cardiovascular Risk Factors and Calcified Plaque Burden. (2018 Feb)Weiberg DJ Nucl Med
29789655Cigarette smoke promotes HIV infection of primary bronchial epithelium and additively suppresses CFTR function. (2018 May 22)Chinnapaiyan SSci Rep
24318111HIV envelope protein gp120-induced apoptosis in lung microvascular endothelial cells by concerted upregulation of EMAP II and its receptor, CXCR3. (2014 Feb 15)Green LAAm J Physiol Lung Cell Mol Physiol