Gene: SEMA3B

7869
LUCA-1|SEMA5|SEMAA|SemA|semaV
semaphorin 3B
protein-coding
3p21.31
Ensembl:ENSG00000012171 MIM:601281 Vega:OTTHUMG00000156970 UniprotKB:Q13214
NG_032938.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.864e-1 (AD)  7.790e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10692467chr3:50313021SEMA3BGene body2.001e-4Alcohol use disorders26763658
cg11039694chr3:50304941SEMA3BPromoter6.641e-4Alcohol use disorders26763658
cg22927302chr3:50304463SEMA3B1.700e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TSPAN150.901
CNP0.89
MAL0.888
COL9A20.88
PRR180.88
EFS0.872
CMTM50.872
ELOVL10.868
CARNS10.867
HSPA20.867

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.384
CNGB1-0.369
BEND4-0.361
OR4F5-0.358
GPR153-0.356
HCN4-0.356
WNT2-0.355
CUX2-0.349
HS6ST3-0.345
GPR26-0.334

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3B mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of SEMA3B mRNA22230336
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SEMA3B mRNA24449571
D001280AtrazineAtrazine results in decreased expression of SEMA3B mRNA25929836
C487081belinostatbelinostat results in decreased expression of SEMA3B mRNA27188386
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to SEMA3B promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SEMA3B mRNA27195522
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of SEMA3B mRNA]24758408
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of SEMA3B mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SEMA3B mRNA19619570
D004958EstradiolEstradiol results in increased expression of SEMA3B mRNA19619570|2475840
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SEMA3B mRNA28628672
C006780bisphenol Abisphenol A results in decreased methylation of SEMA3B promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of SEMA3B mRNA24066056
C006780bisphenol Abisphenol A results in increased expression of SEMA3B mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SEMA3B mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SEMA3B mRNA18974090
D019256Cadmium ChlorideCadmium Chloride affects the expression of SEMA3B mRNA22110744
D002186CannabinoidsCannabinoids results in increased expression of SEMA3B mRNA17205118
D004390ChlorpyrifosChlorpyrifos results in decreased expression of SEMA3B mRNA20350560
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of SEMA3B20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SEMA3B gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SEMA3B mRNA20938992
D003042CocaineCocaine results in increased expression of SEMA3B mRNA17205118
D003042CocaineCocaine results in increased expression of SEMA3B mRNA15691709
D019327Copper SulfateCopper Sulfate results in decreased expression of SEMA3B mRNA19549813
D003471CuprizoneCuprizone results in increased expression of SEMA3B mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of SEMA3B mRNA20106945|2556210
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SEMA3B mRNA28628672
D003976DiazinonDiazinon results in increased methylation of SEMA3B gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SEMA3B mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SEMA3B mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SEMA3B mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of SEMA3B mRNA18042831
C058705diethyl malatediethyl malate affects the expression of SEMA3B mRNA24814887
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of SEMA3B mRNA24535843
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of SEMA3B gene23968726
D002117CalcitriolCalcitriol results in increased expression of SEMA3B mRNA12040012|1600243
D002117CalcitriolCalcitriol results in increased expression of SEMA3B protein21933904
D002117CalcitriolKetoconazole promotes the reaction [Calcitriol results in increased expression of SEMA3B mRNA]12040012
D002117CalcitriolMifepristone inhibits the reaction [Calcitriol results in increased expression of SEMA3B protein]21933904
D002117CalcitriolSEMA3B protein results in increased susceptibility to Calcitriol21933904
D002117Calcitrioltelmisartan inhibits the reaction [Calcitriol results in increased expression of SEMA3B protein]21933904
C118739entinostatentinostat results in increased expression of SEMA3B mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEMA3B mRNA"27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of SEMA3B20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SEMA3B gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SEMA3B mRNA20938992
C039281furanfuran results in increased expression of SEMA3B mRNA27387713
D017313FenretinideFenretinide results in increased expression of SEMA3B mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SEMA3B mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SEMA3B mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SEMA3B mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SEMA3B mRNA27392435
D007654KetoconazoleKetoconazole promotes the reaction [Calcitriol results in increased expression of SEMA3B mRNA]12040012
D007854LeadLead affects the expression of SEMA3B mRNA28903495
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SEMA3B mRNA12057914
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of SEMA3B20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SEMA3B gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SEMA3B mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of SEMA3B mRNA21678067
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SEMA3B mRNA26011545
D015735MifepristoneMifepristone inhibits the reaction [Calcitriol results in increased expression of SEMA3B protein]21933904
D015735MifepristoneMifepristone inhibits the reaction [Progesterone results in increased expression of SEMA3B protein]21933904
D015735MifepristoneSEMA3B protein results in increased susceptibility to Mifepristone21933904
D009151Mustard GasMustard Gas results in increased expression of SEMA3B mRNA25102026
D009532NickelNickel results in decreased expression of SEMA3B mRNA25583101
D000073878Palm OilPalm Oil results in increased expression of SEMA3B mRNA18042831
D010622PhencyclidinePhencyclidine results in decreased expression of SEMA3B mRNA17205118
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of SEMA3B mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of SEMA3B mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of SEMA3B mRNA19482888
D010705PhosgenePhosgene affects the expression of SEMA3B mRNA16300373
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of SEMA3B gene23968726
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of SEMA3B mRNA20660070
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone results in increased expression of SEMA3B protein]21933904
D011374ProgesteroneProgesterone results in increased expression of SEMA3B protein21933904
D011374Progesteronetelmisartan inhibits the reaction [Progesterone results in increased expression of SEMA3B protein]21933904
D011441PropylthiouracilPropylthiouracil results in increased expression of SEMA3B mRNA24780913
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of SEMA3B mRNA19059307
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of SEMA3B mRNA16202921
C059514resveratrolresveratrol results in increased expression of SEMA3B mRNA25888808
D012643SeleniumSelenium results in increased expression of SEMA3B mRNA19244175
C078903seocalcitolseocalcitol results in increased expression of SEMA3B mRNA12040012
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SEMA3B mRNA25895662
C075117squalestatin 1squalestatin 1 results in increased expression of SEMA3B mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of SEMA3B mRNA27225895
D013629Tamoxifen[Tamoxifen co-treated with ESR1 protein] results in increased expression of SEMA3B mRNA19059307
C084178telmisartantelmisartan inhibits the reaction [Calcitriol results in increased expression of SEMA3B protein]21933904
C084178telmisartantelmisartan inhibits the reaction [Progesterone results in increased expression of SEMA3B protein]21933904
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SEMA3B mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SEMA3B mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SEMA3B mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SEMA3B promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SEMA3B mRNA22298810
D014212TretinoinTretinoin results in increased expression of SEMA3B mRNA17452250
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of SEMA3B mRNA19042947
D014635Valproic AcidValproic Acid results in increased methylation of SEMA3B gene29154799
D014638VanadatesVanadates results in increased expression of SEMA3B mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SEMA3B gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of SEMA3B mRNA26682919
C111237vorinostatvorinostat results in decreased expression of SEMA3B mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0030215semaphorin receptor binding-IBA21873635  
GO:0038191neuropilin binding-IBA21873635  
GO:0045499chemorepellent activity-IBA21873635  
GO:0045499chemorepellent activity-TAS22998873  
GO ID GO Term Qualifier Evidence PubMed
GO:0001755neural crest cell migration-IBA21873635  
GO:0007267cell-cell signaling-TAS8633026  
GO:0007411axon guidance-TAS8633026  
GO:0030335positive regulation of cell migration-IBA21873635  
GO:0048843negative regulation of axon extension involved in axon guidance-IBA21873635  
GO:0050919negative chemotaxis-IBA21873635  
GO:0061643chemorepulsion of axon-TAS22998873  
GO:0071526semaphorin-plexin signaling pathway-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005783endoplasmic reticulum-IEA-  
GO:0005887integral component of plasma membrane-IBA21873635  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
12075701Molecular pathogenesis of lung cancer and potential translational applications. (2002 May-Jun)Minna JDCancer J
20521346CpG island methylator phenotype involving chromosome 3p confers an increased risk of non-small cell lung cancer. (2010 Jun)Liu ZJ Thorac Oncol