Gene: MANF

7873
ARMET|ARP
mesencephalic astrocyte derived neurotrophic factor
protein-coding
3p21.2
Ensembl:ENSG00000145050 MIM:601916 Vega:OTTHUMG00000156897 UniprotKB:P55145
NG_012652.3
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.883e-1 (AD)  6.285e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2217938chr3:51388243 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs2304512chr3:51388050 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1370124chr3:51384757 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08058672chr3:51423212MANF4.200e-15Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNAJB110.889
HSPA50.887
PDIA60.865
STIP10.859
XBP10.85
PDIA40.844
FKBP40.839
HSP90B10.837
SDF2L10.821
TARS0.818

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.49
OR4F29-0.449
P2RY14-0.283
CC2D2B-0.262
TTC16-0.254
OMD-0.252
C16orf96-0.252
ALDH1L1-AS2-0.249
CCT6B-0.243
GLI1-0.238

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MANF mRNA"28903501
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in increased expression of MANF mRNA"22101062
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MANF mRNA"25614096
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MANF mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MANF mRNA"15215175
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of MANF mRNA"19561079
D000082AcetaminophenAcetaminophen results in increased expression of MANF mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of MANF mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of MANF mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MANF gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MANF mRNA19770486
C006632arsenic trioxidearsenic trioxide results in decreased expression of MANF mRNA20458559
D001280AtrazineAtrazine results in decreased expression of MANF mRNA22378314
C547126AZM551248AZM551248 results in increased expression of MANF mRNA22323515
C028559bathocuproine sulfonatebathocuproine sulfonate results in decreased expression of MANF mRNA16973896
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of MANF mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to MANF promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MANF mRNA19770486|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MANF mRNA21569818
D004958EstradiolEstradiol results in increased expression of MANF mRNA20106945
C006780bisphenol Abisphenol A affects the expression of MANF mRNA21786754|2355768
C006780bisphenol A[bisphenol A co-treated with Polystyrenes] results in increased expression of MANF mRNA28793400
C006780bisphenol Abisphenol A affects the expression of MANF mRNA20170705
C006780bisphenol Abisphenol A results in increased expression of MANF mRNA25912373
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MANF mRNA28628672
C006780bisphenol Abisphenol A results in decreased methylation of MANF promoter27312807
C006780bisphenol Abisphenol A results in increased expression of MANF mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MANF mRNA17484886|2733941
C100187chloropicrinchloropicrin affects the expression of MANF mRNA26352163
D002857ChromiumChromium results in decreased expression of MANF mRNA17547211
D002994ClofibrateClofibrate results in decreased expression of MANF mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of MANF mRNA22300585
C018021cobaltous chloridecobaltous chloride results in increased expression of MANF mRNA24612858
C018021cobaltous chloridecobaltous chloride results in decreased expression of MANF mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of MANF mRNA16973896
D019327Copper SulfateCopper Sulfate results in decreased expression of MANF mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of MANF mRNA19159671|2010694
D016572CyclosporineCyclosporine results in increased expression of MANF mRNA23308384|2504735
D016572CyclosporineCyclosporine results in increased expression of MANF protein25047351
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MANF mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MANF mRNA28628672
D002945CisplatinCisplatin inhibits the reaction [Piroxicam results in decreased expression of MANF mRNA]21858171
D002945CisplatinCisplatin results in decreased expression of MANF mRNA27594783
D002945CisplatinCisplatin results in increased expression of MANF mRNA19561079
D004041Dietary FatsDietary Fats affects the expression of MANF mRNA19680557
D004041Dietary FatsDietary Fats results in increased expression of MANF mRNA18042831
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of MANF mRNA17547211
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of MANF mRNA28939011
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MANF mRNA20227414
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MANF mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MANF mRNA16174780|1646718
D004997Ethinyl Estradiolfulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of MANF mRNA]16467188
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MANF mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MANF mRNA20170705|2686566
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MANF mRNA16174780|1940095
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MANF mRNA23550701
C070081fulvestrantfulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of MANF mRNA]16467188
C070081fulvestrantfulvestrant inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MANF mRNA]16467188
D019833GenisteinGenistein results in increased expression of MANF mRNA26865667
D005897GlafenineGlafenine results in increased expression of MANF mRNA24136188
C010974glyphosateglyphosate results in increased expression of MANF mRNA25636363
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of MANF mRNA26846883
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of MANF mRNA15458575
C492448ICG 001ICG 001 results in decreased expression of MANF mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MANF mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MANF mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MANF mRNA28628672
C544151jinfukangjinfukang results in increased expression of MANF mRNA27392435
D007649KetamineKetamine results in decreased expression of MANF mRNA20080153
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MANF mRNA"18930950
D008694MethamphetamineMethamphetamine results in increased expression of MANF mRNA19564919
D008694MethamphetamineSCH 23390 inhibits the reaction [Methamphetamine results in increased expression of MANF mRNA]19564919
D008777MethyltestosteroneMethyltestosterone results in decreased expression of MANF mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MANF mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MANF mRNA"25554681|2562005
C022838nickel chloridenickel chloride results in increased expression of MANF mRNA24612858
C012655nimesulidenimesulide results in increased expression of MANF mRNA24136188
C570897NSC668394NSC668394 results in increased expression of MANF mRNA27137931
D019319Okadaic AcidOkadaic Acid results in increased expression of MANF mRNA28939011
D010100OxygenOxygen deficiency results in decreased expression of MANF mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in decreased expression of MANF mRNA]22629407
D000073878Palm OilPalm Oil affects the expression of MANF mRNA19680557
D000073878Palm OilPalm Oil results in increased expression of MANF mRNA18042831
D010269ParaquatParaquat results in decreased expression of MANF mRNA15458575
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MANF mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of MANF mRNA23811191
D010894PiroxicamCisplatin inhibits the reaction [Piroxicam results in decreased expression of MANF mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of MANF mRNA21858171
D011137Polystyrenes[bisphenol A co-treated with Polystyrenes] results in increased expression of MANF mRNA28793400
D011192Potassium DichromatePotassium Dichromate results in decreased expression of MANF mRNA17547211
D011374ProgesteroneProgesterone results in increased expression of MANF mRNA18037150
D011374ProgesteroneProgesterone affects the expression of MANF mRNA17251523
D015125OxyquinolineOxyquinoline results in decreased expression of MANF mRNA21632981
C534628SCH 23390SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of MANF mRNA]19564919
D012822Silicon DioxideSilicon Dioxide results in increased expression of MANF mRNA23221170
C017947sodium arsenitesodium arsenite results in decreased expression of MANF mRNA28595984
C016104sodium bichromatesodium bichromate results in increased expression of MANF mRNA24612858
C025462sulindac sulfidesulindac sulfide results in increased expression of MANF mRNA16184548
D016559TacrolimusTacrolimus results in increased expression of MANF mRNA25270620
D013629TamoxifenTamoxifen affects the expression of MANF mRNA17555576|2093736
D013629TamoxifenTamoxifen results in increased expression of MANF mRNA19400957
D013629TamoxifenTamoxifen results in increased expression of MANF mRNA19400957
D013749Tetrachlorodibenzodioxinfulvestrant inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MANF mRNA]16467188
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MANF mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MANF mRNA16467188|1794274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MANF mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of MANF mRNA22378314
C009495titanium dioxidetitanium dioxide results in increased expression of MANF mRNA23557971|2776080
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of MANF mRNA17982090
D014303TrinitrotolueneTrinitrotoluene affects the expression of MANF mRNA21346803
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MANF mRNA"26743178
C057693troglitazonetroglitazone results in increased expression of MANF mRNA28973697
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MANF mRNA"18930950
D014415TunicamycinTunicamycin results in increased expression of MANF mRNA15458575
D014415TunicamycinTunicamycin results in increased expression of MANF mRNA22378314
D014415TunicamycinTunicamycin results in increased expression of MANF mRNA22001960
D014520UrethaneUrethane results in increased expression of MANF mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of MANF mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of MANF mRNA17292431|1796380
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MANF gene25560391
C016837zinc chloridezinc chloride results in decreased expression of MANF mRNA16973896

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0008083growth factor activity-IEA-  
GO:0008289lipid binding-IPI29497057  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0006986response to unfolded protein-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0031175neuron projection development-IBA21873635  
GO:0071542dopaminergic neuron differentiation-IBA21873635  
GO:1905897regulation of response to endoplasmic reticulum stress-IMP29497057  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005634nucleus-HDA21630459  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005788endoplasmic reticulum lumen-IDA29497057  
GO:0005829cytosol-TAS-  
GO:0033018sarcoplasmic reticulum lumen-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal