Gene: ST8SIA4

7903
PST|PST1|SIAT8D|ST8SIA-IV
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
protein-coding
5q21.1
Ensembl:ENSG00000113532 MIM:602547 Vega:OTTHUMG00000128727 UniprotKB:Q92187
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.295e-1 (AD)  2.425e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EMB0.769
KCNJ50.762
CTSC0.759
DENND2D0.745
NABP10.726
ARHGAP180.723
MAFB0.718
ARHGAP150.716
TRAF3IP30.715
LPCAT20.711

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNTFR-0.389
HES6-0.381
CABLES1-0.37
GRIN2C-0.361
SALL3-0.358
GPT-0.354
NWD1-0.354
EYA2-0.35
PLIN4-0.349
GPR37L1-0.347

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of ST8SIA4 mRNA"26377693
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of ST8SIA4 mRNA"19095052
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ST8SIA4 mRNA"27291303
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ST8SIA4 mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST8SIA4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST8SIA4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST8SIA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST8SIA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST8SIA4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST8SIA4 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ST8SIA4 mRNA17562736
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of ST8SIA4 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ST8SIA4 gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of ST8SIA4 mRNA21757418
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of ST8SIA4 mRNA"23195993
D005680gamma-Aminobutyric Acidgamma-Aminobutyric Acid results in decreased expression of ST8SIA4 mRNA17845906
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ST8SIA4 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of ST8SIA4 mRNA26705709
C015001arsenitearsenite results in increased methylation of ST8SIA4 promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of ST8SIA4 mRNA"18687144
D001280AtrazineAtrazine results in decreased expression of ST8SIA4 mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of ST8SIA4 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of ST8SIA4 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of ST8SIA4 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ST8SIA4 mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of ST8SIA4 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ST8SIA4 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ST8SIA4 mRNA22228805
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ST8SIA4 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of ST8SIA4 mRNA25321415
D004958EstradiolEstradiol results in increased expression of ST8SIA4 mRNA19619570
C006780bisphenol Abisphenol A results in decreased expression of ST8SIA4 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of ST8SIA4 mRNA26079696
D002104CadmiumCadmium results in decreased expression of ST8SIA4 mRNA21120746
D000068579CelecoxibCelecoxib results in increased expression of ST8SIA4 mRNA28201806
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ST8SIA4 mRNA20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of ST8SIA4 mRNA27858113
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of ST8SIA4 mRNA20971185
D003300CopperCopper deficiency results in increased expression of ST8SIA4 mRNA26033743
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ST8SIA4 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of ST8SIA4 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of ST8SIA4 mRNA19167446
D003471CuprizoneCuprizone results in decreased expression of ST8SIA4 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of ST8SIA4 mRNA20106945
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of ST8SIA4 mRNA23914054
D004041Dietary FatsDietary Fats results in increased expression of ST8SIA4 mRNA28031460
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of ST8SIA4 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of ST8SIA4 mRNA21233418
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ST8SIA4 mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ST8SIA4 mRNA23649840
C017690fenvaleratefenvalerate affects the expression of ST8SIA4 mRNA20003521
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ST8SIA4 mRNA20938992
D007052IbuprofenIbuprofen results in increased expression of ST8SIA4 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ST8SIA4 mRNA25613284
C029891lead chloridelead chloride results in decreased expression of ST8SIA4 mRNA18499259
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ST8SIA4 mRNA21641980
C042720mercuric bromidemercuric bromide results in increased expression of ST8SIA4 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST8SIA4 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ST8SIA4 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ST8SIA4 mRNA23179753|2718838
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ST8SIA4 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of ST8SIA4 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ST8SIA4 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of ST8SIA4 mRNA19812364
D009532NickelNickel results in decreased expression of ST8SIA4 mRNA23195993
D009532NickelNickel results in increased expression of ST8SIA4 mRNA25583101
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of ST8SIA4 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ST8SIA4 mRNA25729387
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of ST8SIA4 mRNA19095052
D010643PhenoxybenzaminePhenoxybenzamine results in decreased expression of ST8SIA4 mRNA17845906
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST8SIA4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ST8SIA4 mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of ST8SIA4 mRNA23557933
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of ST8SIA4 mRNA19167446
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ST8SIA4 mRNA19073995
D012834SilverSilver results in decreased expression of ST8SIA4 mRNA26551752
C017947sodium arsenitesodium arsenite results in decreased expression of ST8SIA4 mRNA17682005
C017947sodium arsenitesodium arsenite results in increased expression of ST8SIA4 mRNA23811142
D053260SootSoot results in decreased expression of ST8SIA4 mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ST8SIA4 mRNA21641980
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ST8SIA4 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ST8SIA4 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ST8SIA4 mRNA26377647
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ST8SIA4 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of ST8SIA4 mRNA27760801
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ST8SIA4 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of ST8SIA4 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of ST8SIA4 mRNA21934132
C032910triadimefontriadimefon results in decreased expression of ST8SIA4 mRNA26790661
C012589trichostatin Atrichostatin A results in increased expression of ST8SIA4 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ST8SIA4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ST8SIA4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of ST8SIA4 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ST8SIA4 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ST8SIA4 gene25560391
C025643vinclozolinvinclozolin results in increased expression of ST8SIA4 mRNA23034163
C111237vorinostatvorinostat results in increased expression of ST8SIA4 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003828alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity-IDA10766765  
GO:0003828alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity-TAS-  
GO:0033691sialic acid binding-IC10766765  
GO ID GO Term Qualifier Evidence PubMed
GO:0001574ganglioside biosynthetic process-IDA10766765  
GO:0006464cellular protein modification process-TAS7854457  
GO:0006486protein glycosylation-IDA10766765  
GO:0006486protein glycosylation-IEA-  
GO:0006491N-glycan processing-IDA10766765  
GO:0007399nervous system development-TAS9054414  
GO:0009311oligosaccharide metabolic process-IDA10766765  
GO:0097503sialylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-375165NCAM signaling for neurite out-growthTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4085001Sialic acid metabolismTAS
R-HSA-419037NCAM1 interactionsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-446219Synthesis of substrates in N-glycan biosythesisTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26230583Differential Gene Expression in Colon Tissue Associated With Diet, Lifestyle, and Related Oxidative Stress. (2015)Slattery MLPLoS One