Gene: KCTD15

79047
-
potassium channel tetramerization domain containing 15
protein-coding
19q13.11
Ensembl:ENSG00000153885 MIM:615240 Vega:OTTHUMG00000180475 UniprotKB:Q96SI1
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.372e-1 (AD)  7.347e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02973307chr19:34302998KCTD154.010e-9Maternal smoking in pregnancy27040690
cg02973307chr19:34302998KCTD152.250e-10Maternal smoking in pregnancy27040690
cg02973307chr19:34302998KCTD155.290e-13Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HHIPL10.818
CCDC85C0.807
ADCYAP1R10.8
TLE10.799
RAVER20.797
ATP1A20.78
WWC10.772
ZNF4230.769
CHRDL10.765
SERPINE20.763

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.529
OR4F29-0.482
NPFFR2-0.358
RASEF-0.353
SH2D1B-0.347
THEMIS-0.341
SEMA3E-0.334
SMYD1-0.333
GIPR-0.31
PTPRH-0.309

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of KCTD15 mRNA19041380
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of KCTD15 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KCTD15 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KCTD15 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KCTD15 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KCTD15 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KCTD15 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCTD15 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCTD15 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of KCTD15 mRNA17562736
D000447AldehydesAldehydes results in decreased expression of KCTD15 mRNA25014914
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of KCTD15 mRNA24449571
D001151ArsenicArsenic affects the methylation of KCTD15 gene25304211
D001280AtrazineAtrazine results in decreased expression of KCTD15 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of KCTD15 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of KCTD15 gene25435355
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of KCTD15 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KCTD15 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of KCTD15 mRNA25594700
C006780bisphenol Abisphenol A affects the expression of KCTD15 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of KCTD15 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of KCTD15 mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of KCTD15 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KCTD15 gene20938992
C031180chrysenechrysene results in increased expression of KCTD15 mRNA26377693
D016572CyclosporineCyclosporine results in increased expression of KCTD15 mRNA20106945
D003703DemecolcineDemecolcine results in decreased expression of KCTD15 mRNA23649840
D003976DiazinonDiazinon results in increased methylation of KCTD15 gene22964155
D002945CisplatinCisplatin results in decreased expression of KCTD15 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of KCTD15 mRNA22023808
C000944dicrotophosdicrotophos results in increased expression of KCTD15 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of KCTD15 mRNA25016146
C118739entinostatentinostat results in decreased expression of KCTD15 mRNA27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of KCTD15 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of KCTD15 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KCTD15 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of KCTD15 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KCTD15 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of KCTD15 mRNA23649840
C039281furanfuran results in increased expression of KCTD15 mRNA27387713
C492448ICG 001ICG 001 results in increased expression of KCTD15 mRNA26191083
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KCTD15 mRNA23430699|2675264
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KCTD15 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of KCTD15 mRNA23649840
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of KCTD15 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of KCTD15 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of KCTD15 mRNA"25620056
C022838nickel chloridenickel chloride affects the expression of KCTD15 mRNA22110744
C029938nickel sulfatenickel sulfate results in decreased expression of KCTD15 mRNA16780908
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of KCTD15 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of KCTD15 mRNA25729387
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KCTD15 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of KCTD15 mRNA23892564
C046012pentanalpentanal results in decreased expression of KCTD15 mRNA26079696
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of KCTD15 mRNA22714537
C005556propionaldehydepropionaldehyde results in decreased expression of KCTD15 mRNA26079696
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of KCTD15 mRNA21427059
D012822Silicon DioxideSilicon Dioxide results in decreased expression of KCTD15 mRNA25351596
C016104sodium bichromatesodium bichromate affects the expression of KCTD15 mRNA22110744
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KCTD15 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KCTD15 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KCTD15 mRNA19933214
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of KCTD15 mRNA25729387
D019772TopotecanTopotecan results in increased expression of KCTD15 mRNA25729387
C012589trichostatin Atrichostatin A results in decreased expression of KCTD15 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of KCTD15 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of KCTD15 mRNA17127020
D014520UrethaneUrethane results in decreased expression of KCTD15 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCTD15 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of KCTD15 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of KCTD15 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in decreased expression of KCTD15 mRNA20546886|2142705
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of KCTD15 gene25560391
C111237vorinostatvorinostat results in decreased expression of KCTD15 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0042802identical protein binding-IPI27152988  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IEA-  
GO:0051260protein homooligomerization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsIEA
R-HSA-8866904Negative regulation of activity of TFAP2 (AP-2) family transcription factorsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23978819Generalization of adiposity genetic loci to US Hispanic women. (2013 Aug 26)Graff MNutr Diabetes