Gene: TRPM8

79054
LTRPC6|LTrpC-6|TRPP8|trp-p8
transient receptor potential cation channel subfamily M member 8
protein-coding
2q37.1
Ensembl:ENSG00000144481 MIM:606678 Vega:OTTHUMG00000059129 UniprotKB:Q7Z2W7
NC_000002.12
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.849e-2 (AD)  3.210e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12992084chr2:233946710 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs12472151chr2:233944048 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRPH0.713
HMX30.68
CCDC1400.68
SIM10.675
LHX90.674
C9orf1350.67
SIX60.663
CALCR0.661
HAS20.656
TRH0.655

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TPCN1-0.304
CABLES1-0.302
SCRT1-0.297
SLC14A1-0.295
FUT2-0.291
PLIN4-0.285
HIF3A-0.284
KLKB1-0.279
TEX29-0.278
COL5A3-0.278

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00825MentholSmall Molecule2216-51-5ApprovedTarget
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Menthol results in increased activity of TRPM8]"15046718
C5622423-(7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl)-1-oxa-2-azaspiro(4.5)dec-2-ene3-(7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl)-1-oxa-2-azaspiro(4.5)dec-2-ene binds to and results in decreased activity of TRPM8 protein21128593
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TRPM8 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPM8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPM8 mRNA"27188386
C0683146-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [icilin inhibits the reaction [Menthol results in increased activity of TRPM8 protein]]19363131
C0683146-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]19363131
C0683146-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Menthol inhibits the reaction [Menthol results in increased activity of TRPM8 protein]]19363131
C0683146-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]19363131
D000082AcetaminophenAcetaminophen results in decreased expression of TRPM8 mRNA22230336
D000096AcetoneTRPM8 protein results in increased susceptibility to Acetone17481392
C004471allyl isothiocyanateallyl isothiocyanate results in increased activity of TRPM8 protein29054683
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TRPM8 mRNA16483693
C006780bisphenol Abisphenol A results in decreased expression of TRPM8 mRNA25181051
D002118Calcium[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium16386244
D002118Calcium[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium16386244
D002118Calcium[mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium16386244
D002118CalciumN-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium]16386244
D002118CalciumN-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium]16386244
D002118CalciumN-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium]16386244
D002118CalciumCalcium deficiency inhibits the reaction [Praziquantel results in increased activity of TRPM8 protein]29054683
D002118Calciumicilin promotes the reaction [TRPM8 protein results in increased transport of Calcium]17517434
D002118Calcium[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium16174775
D002118Calcium[Menthol analog binds to and results in increased activity of TRPM8 protein] which results in increased transport of Calcium17517434
D002118CalciumMenthol promotes the reaction [TRPM8 protein results in increased transport of Calcium]17517434|1848589
D002118Calcium[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium16174775
D002118CalciumTRPM8 protein results in increased transport of Calcium17517434|1848589
D002118Calcium[icilin binds to and results in increased activity of TRPM8 protein] which affects the abundance of Calcium23296101
D002118Calcium[Menthol binds to and results in increased activity of TRPM8 protein] which affects the abundance of Calcium23296101
D002118CalciumTRPM8 protein affects the transport of Calcium19363131
D002211CapsaicinCapsaicin results in increased activity of TRPM8 protein29054683
D002211CapsaicinCapsaicin results in decreased expression of TRPM8 mRNA18079164
C071423capsazepinecapsazepine binds to and results in decreased activity of TRPM8 protein19363131
C071423capsazepinecapsazepine inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]19363131
C071423capsazepinecapsazepine inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]19363131
C040879citronellyl acetatecitronellyl acetate affects the activity of TRPM8 protein23562495
D060729Coal AshCoal Ash results in increased activity of TRPM8 protein22155782
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of TRPM8 mRNA26033743
D003300CopperCopper deficiency results in increased expression of TRPM8 mRNA26033743
C500528cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl estercyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester results in decreased activity of TRPM8 protein17314320
D016572CyclosporineCyclosporine results in decreased expression of TRPM8 mRNA27989131
D016264Dextran SulfateDextran Sulfate results in increased expression of TRPM8 mRNA23596210
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of TRPM8 mRNA28962523
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of TRPM8 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of TRPM8 mRNA26033743
D005419FlavonoidsFlavonoids results in increased expression of TRPM8 mRNA18035473
C490483icilinicilin results in increased activity of TRPM8 protein16386244
C490483icilin[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium16386244
C490483icilinN-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium]16386244
C490483icilinicilin promotes the reaction [TRPM8 protein results in increased transport of Calcium]17517434
C490483icilinicilin results in increased activity of TRPM8 protein16174775|2215578
C490483icilin[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium16174775
C490483icilinicilin binds to and results in increased activity of TRPM8 protein17825279
C490483icilin[icilin binds to and results in increased activity of TRPM8 protein] which affects the abundance of Calcium23296101
C490483icilinTRPM8 protein results in increased susceptibility to icilin17481392|2112859
C490483icilin6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [icilin inhibits the reaction [Menthol results in increased activity of TRPM8 protein]]19363131
C490483icilin6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]19363131
C490483icilinicilin binds to and results in increased activity of TRPM8 protein19363131
C490483icilinicilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]19363131
C490483icilinicilin inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]19363131
C490483icilinicilin binds to and results in increased activity of TRPM8 protein18930858|2112859
C490483icilinicilin results in increased activity of TRPM8 protein21128593
D008610MentholMenthol results in increased activity of TRPM8 protein16386244
D008610Menthol[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium16386244
D008610MentholN-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium]16386244
D008610MentholMenthol results in increased activity of TRPM8 protein29054683
D008610MentholMenthol analog binds to and results in increased activity of TRPM8 protein17517434
D008610Menthol[Menthol analog binds to and results in increased activity of TRPM8 protein] which results in increased transport of Calcium17517434
D008610MentholMenthol analog results in increased activity of TRPM8 protein18930858
D008610MentholMenthol inhibits the reaction [Praziquantel results in increased activity of TRPM8 protein]29054683
D008610MentholMenthol promotes the reaction [TRPM8 protein results in increased transport of Calcium]17517434|1848589
D008610MentholMenthol results in increased activity of TRPM8 protein16174775|2823880
D008610Menthol[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium16174775
D008610MentholPraziquantel inhibits the reaction [Menthol results in increased activity of TRPM8 protein]29054683
D008610MentholTRPM8 gene mutant form results in decreased susceptibility to Menthol29054683
D008610Menthol"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Menthol results in increased activity of TRPM8]"15046718
D008610Menthol[Menthol binds to and results in increased activity of TRPM8 protein] which affects the abundance of Calcium23296101
D008610MentholMenthol results in increased activity of TRPM815046718
D008610MentholMenthol results in increased activity of TRPM8 protein16520735
D008610MentholTRPM8 protein affects the susceptibility to Menthol18199758
D008610MentholTRPM8 protein results in increased susceptibility to Menthol17481392
D008610Menthol6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [icilin inhibits the reaction [Menthol results in increased activity of TRPM8 protein]]19363131
D008610Menthol6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Menthol inhibits the reaction [Menthol results in increased activity of TRPM8 protein]]19363131
D008610Menthol6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]19363131
D008610MentholMenthol binds to and results in increased activity of TRPM8 protein19363131
D008610MentholMenthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]19363131
D008610MentholMenthol inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]19363131
D008610MentholMenthol binds to and results in increased activity of TRPM8 protein16617338|1806069
D008610MentholMenthol results in increased activity of TRPM8 protein20538177|2112859
D000432MethanolMethanol binds to and results in increased activity of TRPM8 protein24133248
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TRPM8 mRNA23179753|2800136
C027793mustard oilmustard oil results in increased activity of TRPM8 protein16386244
C027793mustard oil[mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium16386244
C027793mustard oilN-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium]16386244
C532415N-(3-aminopropyl)-2-(((3-methylphenyl) methyl)oxy)-N-(2-thienylmethyl)benzamide hydrochloride saltN-(3-aminopropyl)-2-(((3-methylphenyl) methyl)oxy)-N-(2-thienylmethyl)benzamide hydrochloride salt inhibits the reaction [Praziquantel results in increased activity of TRPM8 protein]29054683
C532415N-(3-aminopropyl)-2-(((3-methylphenyl) methyl)oxy)-N-(2-thienylmethyl)benzamide hydrochloride saltN-(3-aminopropyl)-2-(((3-methylphenyl) methyl)oxy)-N-(2-thienylmethyl)benzamide hydrochloride salt results in decreased activity of TRPM8 protein29054683
C533807N-(4-methoxyphenyl)-4-menthone-3-carboxamideN-(4-methoxyphenyl)-4-menthone-3-carboxamide results in increased activity of TRPM8 protein29054683
C533807N-(4-methoxyphenyl)-4-menthone-3-carboxamideTRPM8 gene mutant form results in decreased susceptibility to N-(4-methoxyphenyl)-4-menthone-3-carboxamide29054683
C475772N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamideN-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium]16386244
C475772N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamideN-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium]16386244
C475772N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamideN-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium]16386244
C475772N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamideN-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Praziquantel results in increased activity of TRPM8 protein]29054683
C475772N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamideN-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide results in decreased activity of TRPM8 protein29054683
C475772N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamideN-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide binds to and results in decreased activity of TRPM8 protein19363131
C475772N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamideN-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]19363131
C475772N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamideN-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]19363131
C025589ochratoxin Aochratoxin A results in decreased expression of TRPM8 mRNA22124623
D010618PhenanthrolinesPhenanthrolines binds to and results in decreased activity of TRPM8 protein19363131
D010618PhenanthrolinesPhenanthrolines inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]19363131
D010618PhenanthrolinesPhenanthrolines inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]19363131
D010634PhenobarbitalPhenobarbital results in increased expression of TRPM8 mRNA19084549
D010656Phenylephrine6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]19363131
D010656Phenylephrine6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]19363131
D010656Phenylephrinecapsazepine inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]19363131
D010656Phenylephrineicilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]19363131
D010656PhenylephrineMenthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]19363131
D010656PhenylephrineN-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]19363131
D010656PhenylephrinePhenanthrolines inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]19363131
D010656PhenylephrinePhenylephrine binds to and results in increased activity of TRPM8 protein19363131
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TRPM8 mRNA19710929
D011189Potassium Chloridecapsazepine inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]19363131
D011189Potassium Chlorideicilin inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]19363131
D011189Potassium ChlorideMenthol inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]19363131
D011189Potassium ChlorideN-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]19363131
D011189Potassium ChloridePhenanthrolines inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein]19363131
D011189Potassium ChloridePotassium Chloride results in increased activity of TRPM8 protein19363131
D011223PraziquantelPraziquantel results in increased activity of TRPM8 protein29054683
D011223PraziquantelCalcium deficiency inhibits the reaction [Praziquantel results in increased activity of TRPM8 protein]29054683
D011223PraziquantelMenthol inhibits the reaction [Praziquantel results in increased activity of TRPM8 protein]29054683
D011223PraziquantelN-(3-aminopropyl)-2-(((3-methylphenyl) methyl)oxy)-N-(2-thienylmethyl)benzamide hydrochloride salt inhibits the reaction [Praziquantel results in increased activity of TRPM8 protein]29054683
D011223PraziquantelN-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Praziquantel results in increased activity of TRPM8 protein]29054683
D011223PraziquantelPraziquantel inhibits the reaction [Menthol results in increased activity of TRPM8 protein]29054683
D011223PraziquantelPraziquantel results in increased activity of TRPM8 protein29054683
D011223PraziquantelTRPM8 gene mutant form results in decreased susceptibility to Praziquantel29054683
D011223PraziquantelTRPM8 gene mutant form results in decreased susceptibility to Praziquantel29054683
C089730rosiglitazonerosiglitazone results in increased expression of TRPM8 mRNA25572481
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TRPM8 mRNA25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRPM8 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TRPM8 mRNA18372398
D014212TretinoinTretinoin results in decreased expression of TRPM8 mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of TRPM8 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of TRPM8 mRNA24935251
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of TRPM8 mRNA23596210
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRPM8 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of TRPM8 mRNA24383497|2493525
D014635Valproic AcidValproic Acid results in increased expression of TRPM8 mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TRPM8 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005262calcium channel activity-TAS-  
GO:0005515protein binding-IPI25559186  
GO:0042803protein homodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006874cellular calcium ion homeostasis-IEA-  
GO:0009409response to cold-IEA-  
GO:0016048detection of temperature stimulus-IEA-  
GO:0050955thermoception-IEA-  
GO:0051289protein homotetramerization-IEA-  
GO:0070207protein homotrimerization-IEA-  
GO:0070588calcium ion transmembrane transport-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005886plasma membrane-IDA25559186  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0045121membrane raft-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-3295583TRP channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28918457Effects of menthol and its interaction with nicotine-conditioned cue on nicotine-seeking behavior in rats. (2017 Dec)Harrison EPsychopharmacology (Berl)
23159643TRPM8 ion channel ligands for new therapeutic applications and as probes to study menthol pharmacology. (2013 Mar 19)Journigan VBLife Sci
25679525Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice. (2015)Ha MAPLoS One
25566005Menthol facilitates the intravenous self-administration of nicotine in rats. (2014)Wang TFront Behav Neurosci
21903934Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. (2011 Dec)Willis DNFASEB J
26881438Chemical Senses Affecting Cough and Swallowing. (2016)Ebihara SCurr Pharm Des