Gene: SLC25A23

79085
APC2|MCSC2|SCaMC-3
solute carrier family 25 member 23
protein-coding
19p13.3
Ensembl:ENSG00000125648 MIM:608746 Vega:OTTHUMG00000180852 UniprotKB:Q9BV35
NC_000019.10
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.628e-2 (AD)  8.762e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14007706chr19:6459035SLC25A231.300e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BAP10.954
NCS10.948
FBXL160.942
PPP1R9B0.936
PDZD40.935
PSD0.933
ST6GALNAC60.932
GIT10.925
SGSM20.923
NSMF0.923

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.817
OR4F29-0.782
TFPI2-0.348
TREM1-0.334
KCNJ15-0.31
C9orf135-0.31
SPINK8-0.309
CD48-0.305
CR1-0.302
FCRLA-0.301

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of SLC25A23 mRNA28329830
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in increased expression of SLC25A23 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC25A23 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC25A23 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of SLC25A23 mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of SLC25A23 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC25A23 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SLC25A23 mRNA24449571
D001280AtrazineAtrazine results in increased expression of SLC25A23 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC25A23 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to SLC25A23 promoter]19654925
C006780bisphenol Abisphenol A affects the expression of SLC25A23 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of SLC25A23 mRNA24768697
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SLC25A23 mRNA27339419
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC25A23 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of SLC25A23 mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SLC25A23 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of SLC25A23 mRNA24386269
D003042CocaineCocaine results in decreased expression of SLC25A23 mRNA16710320
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SLC25A23 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of SLC25A23 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SLC25A23 mRNA24907557
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of SLC25A23 mRNA23640034
D002945CisplatinCisplatin results in decreased expression of SLC25A23 mRNA22023808
C000944dicrotophosdicrotophos results in increased expression of SLC25A23 mRNA28302478
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of SLC25A23 mRNA28329830
D005472FluorouracilFluorouracil affects the expression of SLC25A23 mRNA16584549
D005485FlutamideFlutamide results in decreased expression of SLC25A23 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SLC25A23 gene20938992
C039281furanfuran results in decreased expression of SLC25A23 mRNA26194646
D003932HeroinHeroin results in decreased expression of SLC25A23 mRNA16710320
D017313FenretinideFenretinide results in decreased expression of SLC25A23 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SLC25A23 mRNA20044591
C492448ICG 001ICG 001 results in increased expression of SLC25A23 mRNA26191083
D007854LeadLead affects the expression of SLC25A23 mRNA28903495
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SLC25A23 mRNA21641980|2308674
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SLC25A23 mRNA26378955
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SLC25A23 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SLC25A23 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SLC25A23 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLC25A23 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLC25A23 mRNA"25620056
C051752nefazodonenefazodone results in decreased expression of SLC25A23 mRNA24136188
D009532NickelNickel results in decreased expression of SLC25A23 mRNA25583101
C012655nimesulidenimesulide results in decreased expression of SLC25A23 mRNA24136188
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SLC25A23 mRNA20971185
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SLC25A23 mRNA19162173
C006253pirinixic acidpirinixic acid results in increased expression of SLC25A23 mRNA17426115
C006253pirinixic acidpirinixic acid results in decreased expression of SLC25A23 mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased expression of SLC25A23 mRNA23557933
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of SLC25A23 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLC25A23 mRNA25895662
C016104sodium bichromatesodium bichromate affects the expression of SLC25A23 mRNA22110744
C016104sodium bichromatesodium bichromate results in decreased expression of SLC25A23 mRNA25993096
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SLC25A23 mRNA21641980|2308674
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SLC25A23 mRNA26378955
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of SLC25A23 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC25A23 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC25A23 mRNA19465110|1977048
D013849ThimerosalThimerosal results in decreased expression of SLC25A23 mRNA27188386
D013853ThioacetamideThioacetamide results in decreased expression of SLC25A23 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SLC25A23 mRNA27255386
D014050TolueneToluene results in decreased expression of SLC25A23 mRNA22967744
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SLC25A23 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of SLC25A23 mRNA28973697
D014415TunicamycinTunicamycin results in decreased expression of SLC25A23 mRNA22378314
C406224valdecoxibvaldecoxib results in decreased expression of SLC25A23 mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of SLC25A23 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of SLC25A23 mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005347ATP transmembrane transporter activity-IBA21873635  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI24430870  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0002082regulation of oxidative phosphorylation-IEA-  
GO:0006851mitochondrial calcium ion transmembrane transport-IMP24430870  
GO:0015866ADP transport-IEA-  
GO:0015867ATP transport-IEA-  
GO:0036444calcium import into the mitochondrion-IMP24430870  
GO:0043457regulation of cellular respiration-IEA-  
GO:0051282regulation of sequestering of calcium ion-IEA-  
GO:0071277cellular response to calcium ion-IEA-  
GO:0097274urea homeostasis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal