Gene: C11orf49

79096
-
chromosome 11 open reading frame 49
protein-coding
11p11.2
Ensembl:ENSG00000149179 Vega:OTTHUMG00000166725 UniprotKB:Q9H6J7
NC_000011.10
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.140e-1 (AD)  5.930e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2903517chr11:46945257 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C11orf680.942
SLC25A110.94
C6orf1360.936
SLC41A30.936
REEP20.935
CDIP10.935
GOLGA7B0.934
TMEM90.934
CEND10.934
TMEM59L0.933

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.699
OR4F29-0.648
TFPI2-0.516
KLRB1-0.459
TBX21-0.458
KCNJ15-0.446
IL18RAP-0.444
SLAMF6-0.442
FOLR3-0.442
CEACAM3-0.441

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of C11ORF49 mRNA22100608
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of C11ORF49 mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of C11ORF49 mRNA"26238291
C006780bisphenol Abisphenol A results in increased expression of C11ORF49 mRNA25181051
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of C11ORF49 mRNA24763279
D019327Copper SulfateCopper Sulfate results in decreased expression of C11ORF49 mRNA19549813
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of C11ORF49 mRNA24834073
D005557FormaldehydeFormaldehyde results in decreased expression of C11ORF49 mRNA23649840
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of C11ORF49 mRNA24763279
D007854LeadLead results in decreased expression of C11ORF49 mRNA19921347
C031895lead chromatelead chromate results in decreased expression of C11ORF49 mRNA23584427
D019772TopotecanC11ORF49 protein affects the susceptibility to Topotecan16217747
D014501UraniumUranium affects the expression of C11ORF49 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of C11ORF49 mRNA15672453
D014520UrethaneUrethane results in decreased expression of C11ORF49 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of C11ORF49 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of C11ORF49 mRNA23179753|2915479

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal