Gene: DEK

7913
D6S231E
DEK proto-oncogene
protein-coding
6p22.3
Ensembl:ENSG00000124795 MIM:125264 Vega:OTTHUMG00000014319 UniprotKB:P35659
NG_042290.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.104e-1 (AD)  7.336e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYNCRIP0.903
SMARCE10.89
GOLGA50.888
CDV30.885
SEC630.882
SERBP10.882
USP10.878
DHX400.877
UBE2J10.877
CD1640.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.67
OR4F29-0.67
HES5-0.211
MUC6-0.205
NUTM2E-0.174
PLA2G5-0.173
SDIM1-0.173
PTGDR2-0.17
ARSF-0.162
NXNL1-0.161

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5244781,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [Estradiol results in increased expression of DEK protein]"23071688
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of DEK mRNA"23829299
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DEK mRNA"19114083
C4861844,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of DEK protein"23071688
D016604Aflatoxin B1Aflatoxin B1 affects the expression of DEK protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DEK gene27153756
D000409AlanineDEK protein results in increased chemical synthesis of and results in increased secretion of Alanine28558019
C013082alpha-ketoisocaproic acidDEK protein results in decreased chemical synthesis of and results in decreased secretion of alpha-ketoisocaproic acid28558019
D001241AspirinAspirin results in increased expression of DEK mRNA15928584
D001280AtrazineAtrazine results in decreased expression of DEK mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DEK mRNA22228805
D004958Estradiol"1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [Estradiol results in increased expression of DEK protein]"23071688
D004958EstradiolDEK protein results in increased susceptibility to Estradiol23071688
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to DEK promoter]23071688
D004958EstradiolEstradiol promotes the reaction [MYC protein binds to DEK promoter]23071688
D004958EstradiolEstradiol results in increased expression of DEK mRNA23071688
D004958EstradiolEstradiol results in increased expression of DEK protein23071688
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of DEK protein]23071688
C006780bisphenol Abisphenol A results in decreased expression of DEK mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of DEK mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DEK gene28505145
D002065BuspironeBuspirone results in decreased expression of DEK mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in increased expression of DEK mRNA26472689
D002392CatechinCatechin results in decreased expression of DEK mRNA15465739
D002737ChloropreneChloroprene results in increased expression of DEK mRNA23125180
D002794CholineDEK protein results in decreased chemical synthesis of and results in increased secretion of Choline28558019
C018021cobaltous chloridecobaltous chloride results in decreased expression of DEK mRNA19320972
D009243NADDEK protein results in increased oxidation of NAD28558019
D019327Copper SulfateCopper Sulfate results in decreased expression of DEK mRNA19549813
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of DEK mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of DEK mRNA19167446
D003401CreatineDEK protein results in increased chemical synthesis of Creatine28558019
D016572CyclosporineCyclosporine results in decreased expression of DEK mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of DEK mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DEK mRNA21266533
D002945CisplatinDEK protein results in decreased susceptibility to Cisplatin21291860
D002945CisplatinCisplatin results in increased phosphorylation of DEK protein22006019
C000944dicrotophosdicrotophos results in decreased expression of DEK mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of DEK mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of DEK mRNA]17854601
D002117CalcitriolCalcitriol results in decreased expression of DEK mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of DEK mRNA21592394
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of DEK mRNA27638505
C034516dimethylamineDEK protein results in increased secretion of dimethylamine28558019
D004317DoxorubicinDoxorubicin results in increased expression of DEK mRNA16579640
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of DEK mRNA20064776
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DEK protein23301498
D000431EthanolDEK protein results in increased secretion of Ethanol28558019
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of DEK mRNA17557909
D005492Folic AcidFolic Acid affects the expression of DEK mRNA17320366
C030544formic acidDEK protein results in decreased chemical synthesis of formic acid28558019
D005632FructoseDEK protein results in decreased chemical synthesis of and results in decreased secretion of Fructose28558019
C069837fullerene C60fullerene C60 results in decreased expression of DEK mRNA19167457
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of DEK protein]23071688
C039281furanfuran results in increased methylation of DEK gene22079235
D005897GlafenineGlafenine results in decreased expression of DEK mRNA24136188
D005947GlucoseDEK protein affects the chemical synthesis of and affects the uptake of Glucose28558019
D005978GlutathioneDEK protein results in decreased chemical synthesis of Glutathione28558019
D005998GlycineDEK protein results in decreased chemical synthesis of and results in increased uptake of Glycine28558019
C492448ICG 001ICG 001 results in increased expression of DEK mRNA26191083
D007294InositolDEK protein results in increased chemical synthesis of and results in decreased secretion of Inositol28558019
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of DEK mRNA25613284
C544151jinfukangjinfukang results in decreased expression of DEK mRNA27392435
C410337K 7174K 7174 results in decreased expression of DEK mRNA24086573
C011890kojic acidkojic acid results in decreased expression of DEK mRNA16595896
D019344Lactic AcidDEK protein results in increased chemical synthesis of and results in increased secretion of Lactic Acid28558019
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of DEK mRNA12634122
D015741MetriboloneMetribolone results in increased expression of DEK mRNA23071688
D015741MetriboloneMetribolone results in increased expression of DEK protein23071688
D009151Mustard GasMustard Gas results in decreased expression of DEK mRNA25102026
C024058N(1)-methylnicotinamideDEK protein results in decreased chemical synthesis of N(1)-methylnicotinamide28558019
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DEK mRNA"25620056
D009532NickelNickel results in decreased expression of DEK mRNA18922574
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of DEK mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of DEK mRNA25729387
D011761Pyrrolidonecarboxylic AcidDEK protein results in decreased chemical synthesis of and results in increased uptake of Pyrrolidonecarboxylic Acid28558019
D010117OxypurinolDEK protein results in increased secretion of Oxypurinol28558019
D010416PentachlorophenolPentachlorophenol results in decreased expression of DEK mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of DEK mRNA27153767
D010767PhosphorylcholineDEK protein results in decreased chemical synthesis of Phosphorylcholine28558019
D011099Polyglutamic AcidDEK protein results in decreased secretion of Polyglutamic Acid28558019
D011374ProgesteroneProgesterone results in increased expression of DEK protein23071688
D011441PropylthiouracilPropylthiouracil results in increased expression of DEK mRNA24780913
D019289Pyruvic AcidDEK protein results in decreased chemical synthesis of and results in decreased secretion of Pyruvic Acid28558019
D011794QuercetinQuercetin results in decreased expression of DEK mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of DEK mRNA19167446
C059514resveratrolresveratrol results in decreased expression of DEK mRNA12002526
C059514resveratrolresveratrol results in decreased expression of DEK protein25505154
D019802Succinic AcidDEK protein affects the chemical synthesis of and affects the secretion of Succinic Acid28558019
D013629TamoxifenDEK protein results in decreased susceptibility to Tamoxifen23071688
D013629TamoxifenTamoxifen results in decreased expression of DEK mRNA23071688
D013629TamoxifenTamoxifen results in decreased expression of DEK protein23071688
D013654TaurineDEK protein results in increased chemical synthesis of Taurine28558019
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of DEK mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of DEK mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DEK mRNA21570461|2637764
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of DEK mRNA25613284
C009495titanium dioxidetitanium dioxide affects the expression of DEK mRNA24023007
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of DEK mRNA25729387
D019772TopotecanTopotecan results in decreased expression of DEK mRNA25729387
D014212TretinoinTretinoin results in decreased expression of DEK mRNA17218384
C012589trichostatin Atrichostatin A affects the expression of DEK mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of DEK mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DEK mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of DEK mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DEK gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0042393histone binding-IBA21873635  
GO:0042393histone binding-IDA12140263  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-TAS-  
GO:0006366transcription by RNA polymerase II-TAS9050861  
GO:0007165signal transduction-TAS9050861  
GO:0019079viral genome replication-TAS9050861  
GO:0045815positive regulation of gene expression, epigenetic-TAS-  
GO:2000779regulation of double-strand break repair-IBA21873635  
GO:2000779regulation of double-strand break repair-IMP21653549  
GO:2001032regulation of double-strand break repair via nonhomologous end joining-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA21653549  
GO:0005654nucleoplasm-TAS-  
GO:0043292contractile fiber-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212165Epigenetic regulation of gene expressionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-5250913Positive epigenetic regulation of rRNA expressionTAS
R-HSA-5250924B-WICH complex positively regulates rRNA expressionTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29289845Decreased plasma DEK Oncogene Levels Correlate with p16-Negative Disease and Advanced Tumor Stage in a Case-Control Study of Patients with Head and Neck Squamous Cell Carcinoma. (2018 Feb)Wise-Draper TTransl Oncol