Gene: MBOAT7

79143
BB1|LENG4|LPIAT|LPLAT|LRC4|MBOA7|MRT57|OACT7|hMBOA-7
membrane bound O-acyltransferase domain containing 7
protein-coding
19q13.42
Ensembl:ENSG00000125505 MIM:606048 Vega:OTTHUMG00000066516 UniprotKB:Q96N66
NG_033045.2
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.365e-1 (AD)  6.144e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CARM10.952
DBN10.94
AP2A20.939
RHBDD20.935
IP6K10.932
MKL10.932
ZER10.931
GPR1620.931
TESK10.931
GPI0.928

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.685
OR4F29-0.632
KLRB1-0.401
KLRF1-0.395
CTNNA3-0.39
TFPI2-0.388
IL18RAP-0.387
SH2D1A-0.381
CD2-0.365
RAI14-0.363

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of MBOAT7 mRNA"19162173
D000082AcetaminophenAcetaminophen affects the expression of MBOAT7 mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MBOAT7 mRNA24449571
C006780bisphenol A[bisphenol A co-treated with Genistein] results in decreased methylation of MBOAT7 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MBOAT7 mRNA28628672
C584509C646 compoundC646 compound results in decreased expression of MBOAT7 mRNA26191083
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MBOAT7 gene20938992
D003471CuprizoneCuprizone results in decreased expression of MBOAT7 mRNA26577399
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MBOAT7 mRNA28628672
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MBOAT7 gene20938992
C069837fullerene C60fullerene C60 results in increased expression of MBOAT7 mRNA19167457
D019833Genistein[bisphenol A co-treated with Genistein] results in decreased methylation of MBOAT7 gene28505145
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of MBOAT7 mRNA17183730
C492448ICG 001ICG 001 results in decreased expression of MBOAT7 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MBOAT7 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MBOAT7 mRNA28628672
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MBOAT7 gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MBOAT7 mRNA"20188158
C568376MT19c compoundMT19c compound results in decreased expression of MBOAT7 mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MBOAT7 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MBOAT7 mRNA"25620056
C028007nickel monoxidenickel monoxide results in increased expression of MBOAT7 mRNA19167457
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of MBOAT7 mRNA18593933
C006253pirinixic acidpirinixic acid results in increased expression of MBOAT7 mRNA18301758
C006253pirinixic acidpirinixic acid results in increased expression of MBOAT7 mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased expression of MBOAT7 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of MBOAT7 mRNA19162173
C030984pyrenepyrene results in decreased expression of MBOAT7 mRNA23656968
C059514resveratrolresveratrol results in increased expression of MBOAT7 protein25505154
D012834SilverSilver results in increased expression of MBOAT7 mRNA28959546
D013849ThimerosalThimerosal results in decreased expression of MBOAT7 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MBOAT7 mRNA28065790
C012589trichostatin Atrichostatin A results in increased expression of MBOAT7 mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of MBOAT7 mRNA15901671
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of MBOAT7 mRNA17183730
D014635Valproic AcidValproic Acid results in increased expression of MBOAT7 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of MBOAT7 gene29154799
C025643vinclozolinvinclozolin results in increased expression of MBOAT7 mRNA22570695
D014810Vitamin EVitamin E results in decreased expression of MBOAT7 mRNA19244175
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of MBOAT7 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038411-acylglycerol-3-phosphate O-acyltransferase activity-TAS-  
GO:0005515protein binding-IPI21903422  
GO:00471442-acylglycerol-3-phosphate O-acyltransferase activity-TAS-  
GO:0071617lysophospholipid acyltransferase activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008654phospholipid biosynthetic process-IEA-  
GO:0021591ventricular system development-IEA-  
GO:0021819layer formation in cerebral cortex-ISS-  
GO:0036149phosphatidylinositol acyl-chain remodeling-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00564Glycerophospholipid metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1482922Acyl chain remodelling of PITAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27575312The genetics of alcohol dependence and alcohol-related liver disease. (2017 Jan)Stickel FJ Hepatol