Gene: ALDH5A1

7915
SSADH|SSDH
aldehyde dehydrogenase 5 family member A1
protein-coding
6p22.3
Ensembl:ENSG00000112294 MIM:610045 Vega:OTTHUMG00000014356 UniprotKB:P51649
NG_008161.1
PubMed
0   ANCO-SNPs
OD|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.321e-1 (AD)  9.147e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPM6A0.913
ABAT0.901
SPARCL10.898
ATPAF10.892
CPE0.891
DDAH10.888
PAICS0.876
TSPAN70.874
FAM213A0.871
ARL6IP10.869

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.766
OR4F29-0.725
SPINK8-0.321
CLEC6A-0.294
DPPA4-0.271
GADL1-0.27
C2orf83-0.266
FCER2-0.262
SH2D1A-0.256
IL24-0.256

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ALDH5A1 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ALDH5A1 mRNA"27188386
C1114204-hydroxybutyric acidALDH5A1 mutant form results in increased abundance of 4-hydroxybutyric acid17438226
C1114204-hydroxybutyric acidALDH5A1 gene mutant form results in increased abundance of 4-hydroxybutyric acid29031482
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ALDH5A1 mRNA"27188386
C5585299-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one"ALDH5A1 gene mutant form results in increased susceptibility to 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one"29031482
C5585299-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one"[ALDH5A1 gene mutant form results in increased susceptibility to 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one] which results in increased abundance of Superoxides"29031482
D000079AcetaldehydeALDH5A1 protein results in increased metabolism of Acetaldehyde18926807
D000082AcetaminophenAcetaminophen affects the expression of ALDH5A1 mRNA25704631
D000082AcetaminophenAcetaminophen results in decreased expression of ALDH5A1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ALDH5A1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of ALDH5A1 mRNA28959563
D000255Adenosine TriphosphateALDH5A1 gene mutant form results in increased abundance of Adenosine Triphosphate29031482
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ALDH5A1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ALDH5A1 mRNA27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of ALDH5A1 mRNA21757418
D000393Air PollutantsAir Pollutants results in decreased expression of ALDH5A1 mRNA25056781
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ALDH5A1 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of ALDH5A1 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of ALDH5A1 mRNA22323515
D001542BenomylBenomyl results in decreased activity of ALDH5A1 protein17010440
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of ALDH5A1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ALDH5A1 mRNA20064835|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ALDH5A1 mRNA20127859|2222880
C006780bisphenol Abisphenol A results in decreased expression of ALDH5A1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of ALDH5A1 mRNA17010207
C006780bisphenol Abisphenol A results in increased methylation of ALDH5A1 gene28505145
D000069286BortezomibBortezomib results in decreased expression of ALDH5A1 mRNA20977926
C013418bromfenacoumbromfenacoum results in increased expression of ALDH5A1 protein28903499
C018475butyraldehydebutyraldehyde results in decreased expression of ALDH5A1 mRNA26079696
D002994ClofibrateClofibrate results in increased expression of ALDH5A1 protein16470657
C018021cobaltous chloridecobaltous chloride results in decreased expression of ALDH5A1 mRNA24386269
D009243NADNAD binds to and affects the activity of ALDH5A1 protein18926807
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of ALDH5A1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of ALDH5A1 mRNA19549813
D003407CreosoteCreosote results in increased expression of ALDH5A1 mRNA19389177
D016572CyclosporineCyclosporine results in decreased expression of ALDH5A1 mRNA20106945|2556210
C017160cypermethrincypermethrin results in decreased expression of ALDH5A1 mRNA22528246
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of ALDH5A1 mRNA23914054
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ALDH5A1 mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ALDH5A1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ALDH5A1 mRNA27392435
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ALDH5A1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALDH5A1 mRNA17942748
D019833GenisteinGenistein results in increased expression of ALDH5A1 mRNA17010207
D005897GlafenineGlafenine results in decreased expression of ALDH5A1 mRNA24136188
C010178heliotrineheliotrine results in decreased expression of ALDH5A1 mRNA26100227
D017313FenretinideFenretinide results in decreased expression of ALDH5A1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ALDH5A1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ALDH5A1 mRNA27392435
D007854LeadLead affects the expression of ALDH5A1 mRNA28903495
C045463leflunomideleflunomide results in decreased expression of ALDH5A1 mRNA28988120
C013099mancozebmancozeb results in decreased activity of ALDH5A1 protein17010440
D008344Maneb[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA23963992
D008344ManebMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA]23963992
D008344ManebSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA]23963992
D008344ManebManeb results in decreased activity of ALDH5A1 protein17010440
D008550MelatoninMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA]23963992
D008628MercuryMercury analog results in decreased expression of ALDH5A1 mRNA25056781
C004925methylmercuric chloridemethylmercuric chloride affects the expression of ALDH5A1 protein27012723
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ALDH5A1 mRNA28001369
C437683motexafin gadoliniummotexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of ALDH5A1 mRNA]16357179
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of ALDH5A1 mRNA16357179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ALDH5A1 mRNA"25554681
C053320n-butoxyacetaldehydeALDH5A1 protein results in increased oxidation of n-butoxyacetaldehyde18940187
C066471NCS 382ALDH5A1 gene mutant form results in increased susceptibility to NCS 38229031482
C066471NCS 382[ALDH5A1 gene mutant form results in increased susceptibility to NCS 382] which results in increased abundance of Superoxides29031482
D009532NickelNickel results in decreased expression of ALDH5A1 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of ALDH5A1 mRNA22714537
C025256nonylphenolnonylphenol results in increased expression of ALDH5A1 mRNA17010207
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of ALDH5A1 mRNA20971185
D010269Paraquat[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA23963992
D010269ParaquatMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA]23963992
D010269ParaquatSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA]23963992
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ALDH5A1 protein26879310
C006253pirinixic acidpirinixic acid results in increased expression of ALDH5A1 mRNA19162173
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of ALDH5A1 mRNA21334430
D011374ProgesteroneProgesterone results in increased expression of ALDH5A1 mRNA23012394
D011522ProtonsProtons results in decreased activity of ALDH5A1 protein18926807
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of ALDH5A1 mRNA26100227
D011794QuercetinQuercetin results in decreased expression of ALDH5A1 mRNA21632981
D017382Reactive Oxygen SpeciesALDH5A1 gene mutant form results in increased abundance of Reactive Oxygen Species29031482
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of ALDH5A1 mRNA21427059
C009238senkirkinesenkirkine results in decreased expression of ALDH5A1 mRNA26100227
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ALDH5A1 mRNA25351596
D012838SilymarinSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA]23963992
C009338succinic semialdehydeALDH5A1 protein results in increased metabolism of succinic semialdehyde17010440|1892680
D013481Superoxides"[ALDH5A1 gene mutant form results in increased susceptibility to 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one] which results in increased abundance of Superoxides"29031482
D013481Superoxides[ALDH5A1 gene mutant form results in increased susceptibility to NCS 382] which results in increased abundance of Superoxides29031482
C501413tesaglitazartesaglitazar results in increased expression of ALDH5A1 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ALDH5A1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALDH5A1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ALDH5A1 mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ALDH5A1 mRNA25613284
C014215tetrahydropalmatinetetrahydropalmatine results in increased expression of ALDH5A1 protein20109541
D019284ThapsigarginThapsigargin results in decreased expression of ALDH5A1 mRNA22378314
D013849ThimerosalThimerosal results in decreased expression of ALDH5A1 mRNA27188386
D013853ThioacetamideThioacetamide results in decreased expression of ALDH5A1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ALDH5A1 protein24486158
D014212TretinoinTretinoin results in increased expression of ALDH5A1 mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ALDH5A1 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of ALDH5A1 mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ALDH5A1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of ALDH5A1 mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of ALDH5A1 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of ALDH5A1 mRNA21427059
D014638VanadatesVanadates results in decreased expression of ALDH5A1 mRNA22714537
D014640VancomycinVancomycin results in increased expression of ALDH5A1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ALDH5A1 gene25560391
C111237vorinostatvorinostat results in decreased expression of ALDH5A1 mRNA27188386
C576808XL765ALDH5A1 gene mutant form results in increased susceptibility to XL76529031482
D019345Zinc Acetatemotexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of ALDH5A1 mRNA]16357179
D019345Zinc AcetateZinc Acetate results in increased expression of ALDH5A1 mRNA16357179

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004777succinate-semialdehyde dehydrogenase (NAD+) activity-IBA21873635  
GO:0004777succinate-semialdehyde dehydrogenase (NAD+) activity-IDA9683595  
GO:0004777succinate-semialdehyde dehydrogenase (NAD+) activity-ISS7814412  
GO:0004777succinate-semialdehyde dehydrogenase (NAD+) activity-TAS-  
GO:0009013succinate-semialdehyde dehydrogenase [NAD(P)+] activity-IBA21873635  
GO:0009013succinate-semialdehyde dehydrogenase [NAD(P)+] activity-IEA-  
GO:0042803protein homodimerization activity-IC16199352  
GO ID GO Term Qualifier Evidence PubMed
GO:0006006glucose metabolic process-ISS-  
GO:0006083acetate metabolic process-ISS-  
GO:0006105succinate metabolic process-ISS-  
GO:0006536glutamate metabolic process-ISS-  
GO:0006541glutamine metabolic process-ISS-  
GO:0006650glycerophospholipid metabolic process-ISS-  
GO:0006678glucosylceramide metabolic process-IEA-  
GO:0006681galactosylceramide metabolic process-ISS-  
GO:0006749glutathione metabolic process-ISS-  
GO:0007417central nervous system development-IMP9683595  
GO:0009450gamma-aminobutyric acid catabolic process-IDA9683595  
GO:0009450gamma-aminobutyric acid catabolic process-IEA-  
GO:0009450gamma-aminobutyric acid catabolic process-IMP15037717  
GO:0009791post-embryonic development-IEA-  
GO:0022904respiratory electron transport chain-ISS-  
GO:0042135neurotransmitter catabolic process-ISS-  
GO:0046459short-chain fatty acid metabolic process-ISS-  
GO:0051289protein homotetramerization-IDA16199352  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-HDA20833797  
GO:0005739mitochondrion-IDA-  
GO:0005739mitochondrion-ISS-  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00250Alanine, aspartate and glutamate metabolism
hsa00650Butanoate metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-888590GABA synthesis, release, reuptake and degradationTAS
R-HSA-916853Degradation of GABATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10971205Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. (2000 Sep)Vasiliou VPharmacology
24230997ALDH5A1 variability in opioid dependent patients could influence response to methadone treatment. (2014 Mar)Fonseca FEur Neuropsychopharmacol