Gene: FA2H

79152
FAAH|FAH1|FAXDC1|SCS7|SPG35
fatty acid 2-hydroxylase
protein-coding
16q23.1
Ensembl:ENSG00000103089 MIM:611026 Vega:OTTHUMG00000137603 UniprotKB:Q7L5A8
NG_017070.1
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.850e-1 (AD)  4.890e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLK60.952
ERBB30.948
UGT80.947
TF0.945
MAG0.944
SLC45A30.939
GJB10.938
ENPP20.935
MYRF0.933
GPR620.931

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NR2F2-0.361
PAX2-0.333
NEUROD1-0.329
NHS-0.322
WTIP-0.318
LTK-0.303
CALB2-0.303
CUX2-0.3
CERKL-0.297
OLFM4-0.295

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [Dronabinol results in increased expression of FA2H mRNA]23535410
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FA2H mRNA"27188386
C4796355-chloro-1-(4-chlorobenzyl)-3-(phenylthio)indole-2-carboxylic acid5-chloro-1-(4-chlorobenzyl)-3-(phenylthio)indole-2-carboxylic acid results in increased expression of FA2H mRNA23535410
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FA2H mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of FA2H mRNA26690555
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of FA2H mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FA2H mRNA19770486
D000447AldehydesAldehydes results in increased expression of FA2H mRNA25014914
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of FA2H mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of FA2H mRNA19128835
C006632arsenic trioxideFA2H protein results in decreased susceptibility to arsenic trioxide20707922
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of FA2H mRNA"18687144
D001280AtrazineAtrazine results in increased expression of FA2H mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of FA2H mRNA22323515
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of FA2H mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FA2H mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FA2H mRNA22228805
C006780bisphenol Abisphenol A affects the expression of FA2H mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FA2H gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of FA2H mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of FA2H20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FA2H gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FA2H mRNA20938992
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of FA2H mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of FA2H mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of FA2H mRNA26577399|2752363
D016572CyclosporineCyclosporine results in increased expression of FA2H mRNA19770486
D013759Dronabinol2-chloro-5-nitrobenzanilide inhibits the reaction [Dronabinol results in increased expression of FA2H mRNA]23535410
D013759DronabinolDronabinol results in increased expression of FA2H mRNA23535410|2529103
D013759DronabinolMK-886 inhibits the reaction [Dronabinol results in increased expression of FA2H mRNA]23535410
D013759DronabinolMK-886 promotes the reaction [Dronabinol results in increased expression of FA2H mRNA]25291031
D004041Dietary FatsDietary Fats results in increased expression of FA2H mRNA18042831
C118739entinostatentinostat results in increased expression of FA2H mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FA2H mRNA"27188386
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of FA2H mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of FA2H mRNA21233418
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of FA2H20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FA2H gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FA2H mRNA20938992
C412815GW 4064GW 4064 results in decreased expression of FA2H mRNA26655953
C453899GW 7647GW 7647 results in increased expression of FA2H mRNA23535410
C008261lead acetatelead acetate results in increased expression of FA2H mRNA20542052
D008345ManganeseManganese results in increased expression of FA2H mRNA26745496
C025340manganese chloridemanganese chloride results in increased expression of FA2H mRNA26745496
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of FA2H20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FA2H gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FA2H mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of FA2H mRNA17400583
D008727MethotrexateMethotrexate results in increased expression of FA2H mRNA24449571
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of FA2H mRNA"20188158
C060893MK-886MK-886 inhibits the reaction [Dronabinol results in increased expression of FA2H mRNA]23535410
C060893MK-886MK-886 promotes the reaction [Dronabinol results in increased expression of FA2H mRNA]25291031
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of FA2H mRNA20024957
D009532NickelNickel results in decreased expression of FA2H mRNA24768652
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of FA2H mRNA20971185
D000073878Palm OilPalm Oil results in increased expression of FA2H mRNA18042831
C046012pentanalpentanal results in increased expression of FA2H mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of FA2H mRNA19159669
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of FA2H mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of FA2H mRNA20813756
C005556propionaldehydepropionaldehyde results in increased expression of FA2H mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of FA2H mRNA24780913
D015474IsotretinoinIsotretinoin results in decreased expression of FA2H mRNA20436886
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FA2H mRNA25895662
D012906SmokeSmoke results in decreased expression of FA2H mRNA21095227
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FA2H mRNA21998131
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FA2H mRNA28213091
D014212TretinoinTretinoin results in decreased expression of FA2H mRNA23830798
C012589trichostatin Atrichostatin A results in increased expression of FA2H mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of FA2H mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of FA2H mRNA24935251
D001335Vehicle EmissionsVehicle Emissions affects the methylation of FA2H gene25560391
C025643vinclozolinvinclozolin results in increased expression of FA2H mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005506iron ion binding-IEA-  
GO:0020037heme binding-IEA-  
GO:0080132fatty acid alpha-hydroxylase activity-IBA21873635  
GO:0080132fatty acid alpha-hydroxylase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001949sebaceous gland cell differentiation-IEA-  
GO:0006631fatty acid metabolic process-IBA21873635  
GO:0006633fatty acid biosynthetic process-IEA-  
GO:0030148sphingolipid biosynthetic process-TAS-  
GO:0030258lipid modification-IEA-  
GO:0032286central nervous system myelin maintenance-IEA-  
GO:0032287peripheral nervous system myelin maintenance-IEA-  
GO:0042127regulation of cell proliferation-IEA-  
GO:0042634regulation of hair cycle-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0031090organelle membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1660661Sphingolipid de novo biosynthesisTAS
R-HSA-428157Sphingolipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal