Gene: BAG6

7917
BAG-6|BAT3|D6S52E|G3
BCL2 associated athanogene 6
protein-coding
6p21.33
Ensembl:ENSG00000204463 MIM:142590 Vega:OTTHUMG00000031171 UniprotKB:P46379
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
3.997e-1 (AD)  7.471e-1 (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AP3D10.928
PPP6R20.92
CAPN10.918
PRRC2A0.918
TNPO20.918
ALDOA0.917
AP1B10.916
RAB1B0.914
SCAF10.912
STK250.912

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.8
OR4F29-0.751
OR6C74-0.26
SH2D1A-0.258
TFPI2-0.255
KLRB1-0.242
AGTR1-0.239
CTNNA3-0.238
KCNJ15-0.235
IL18RAP-0.232

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of BAG6 mRNA"21354444
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BAG6 mRNA"27291303
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of BAG6 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of BAG6 mRNA"21346803
C0212962-ethoxyethanol2-ethoxyethanol results in increased expression of BAG6 mRNA19643169
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of BAG6 protein26194647
D000082AcetaminophenAcetaminophen results in decreased expression of BAG6 mRNA21420995
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BAG6 mRNA16483693
D001280AtrazineAtrazine results in increased expression of BAG6 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BAG6 mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of BAG6 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of BAG6 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of BAG6 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of BAG620938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of BAG6 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of BAG6 mRNA18353800
D003907DexamethasoneDexamethasone results in decreased expression of BAG6 mRNA25047013
D003976DiazinonDiazinon affects the expression of BAG6 mRNA22546817
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in decreased expression of BAG6 mRNA21858171
C000944dicrotophosdicrotophos results in increased expression of BAG6 mRNA28302478
D004026DieldrinDieldrin results in decreased expression of BAG6 mRNA23041725
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of BAG6 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of BAG6 mRNA22079256
D005485FlutamideFlutamide results in increased expression of BAG6 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of BAG620938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of BAG6 gene20938992
C039281furanfuran results in increased methylation of BAG6 gene22079235
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of BAG6 mRNA21179406
D007854LeadLead affects the splicing of BAG6 mRNA28903495
D007854LeadLead results in decreased expression of BAG6 mRNA19921347
D008628MercuryMercury results in decreased expression of BAG6 mRNA16823088
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of and results in decreased expression of BAG620938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of BAG6 gene20938992
D008727MethotrexateBAG6 protein affects the susceptibility to Methotrexate16217747
C005219methyl cellosolvemethyl cellosolve results in increased expression of BAG6 mRNA19643169
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of BAG6 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of BAG6 promoter"26251327
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of BAG6 protein26879310
C014153pirimiphos methylpirimiphos methyl results in decreased expression of BAG6 mRNA27845199
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in decreased expression of BAG6 mRNA21858171
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of BAG6 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of BAG6 mRNA22079256
C059514resveratrolresveratrol results in increased expression of BAG6 protein25505154
C010327salinomycinsalinomycin results in decreased expression of BAG6 mRNA19682730
D012643SeleniumSelenium results in increased expression of BAG6 mRNA19244175
C017947sodium arsenitesodium arsenite affects the methylation of BAG6 gene28589171
D019311StaurosporineStaurosporine results in decreased expression of BAG6 protein19352495
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BAG6 mRNA21570461|2468072
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of BAG6 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of BAG6 mRNA18042343
D014810Vitamin EVitamin E results in increased expression of BAG6 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IPI18852879  
GO:0005515protein binding-IPI14667819  14960581  16169070  16189514  17353931  17403783  
18765639  18852879  21903422  22807449  23246001  25036637  
25416956  25535373  25713138  26876100  29042515  
GO:0030544Hsp70 protein binding-IEA-  
GO:0031593polyubiquitin modification-dependent protein binding-ISS-  
GO:0031625ubiquitin protein ligase binding-IPI21636303  24981174  
GO:0043022ribosome binding-IDA20676083  
GO:0051787misfolded protein binding-IDA21636303  
GO:0070628proteasome binding-ISS-  
GO:1990381ubiquitin-specific protease binding-IPI24424410  
GO ID GO Term Qualifier Evidence PubMed
GO:0001822kidney development-ISS-  
GO:0002429immune response-activating cell surface receptor signaling pathway-IDA18852879  
GO:0006325chromatin organization-IEA-  
GO:0006511ubiquitin-dependent protein catabolic process-ISS-  
GO:0006915apoptotic process-IDA14960581  
GO:0007130synaptonemal complex assembly-ISS-  
GO:0007283spermatogenesis-ISS-  
GO:0007420brain development-ISS-  
GO:0010498proteasomal protein catabolic process-IMP26565908  
GO:0018393internal peptidyl-lysine acetylation-IDA17403783  
GO:0030101natural killer cell activation-IDA18852879  
GO:0030154cell differentiation-IEA-  
GO:0030324lung development-ISS-  
GO:0030433ubiquitin-dependent ERAD pathway-IDA23129660  24981174  
GO:0030433ubiquitin-dependent ERAD pathway-IMP26565908  
GO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic process-ISS-  
GO:0042127regulation of cell proliferation-IEA-  
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator-IMP17403783  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0045861negative regulation of proteolysis-ISS-  
GO:0045995regulation of embryonic development-ISS-  
GO:0050821protein stabilization-ISS-  
GO:0061857endoplasmic reticulum stress-induced pre-emptive quality control-IMP26565908  
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress-ISS-  
GO:0071712ER-associated misfolded protein catabolic process-IDA23129660  24981174  
GO:0071816tail-anchored membrane protein insertion into ER membrane-IDA20676083  25535373  
GO:1904294positive regulation of ERAD pathway-IMP24424410  
GO:1904378maintenance of unfolded protein involved in ERAD pathway-IMP21636303  
GO:1904379protein localization to cytosolic proteasome complex involved in ERAD pathway-NAS21636303  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA14960581  17403783  21636303  29042515  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA21636303  
GO:0005829cytosol-IDA17403783  20676083  23246001  29042515  
GO:0016020membrane-HDA19946888  
GO:0016020membrane-IDA23246001  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0070062extracellular exosome-IDA18852879  
GO:0071818BAT3 complex-IDA20676083  21636303  25535373  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25884493Association of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell lung cancer (NSCLC) in Croatian and Norwegian populations. (2015)Etokebe GEPLoS One