Gene: CENPO

79172
CENP-O|ICEN-36|MCM21R
centromere protein O
protein-coding
2p23.3
Ensembl:ENSG00000138092 MIM:611504 Vega:OTTHUMG00000125525 UniprotKB:Q9BU64
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.999e-1 (AD)  6.307e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GLE10.863
VPS390.861
C6orf890.855
DPH20.855
VPS520.854
GTF3C20.853
ILF30.85
EXOC70.847
PIGS0.844
KIAA0319L0.843

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.609
OR4F29-0.558
MTRNR2L6-0.294
MTRNR2L9-0.286
PGF-0.278
TMSB15A-0.276
KLRC2-0.257
NKX6-1-0.256
ODAM-0.247
CYP39A1-0.246

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CENPO mRNA"19167446
D000082AcetaminophenAcetaminophen results in decreased expression of CENPO mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of CENPO mRNA22230336
D020106AcrylamideAcrylamide results in increased expression of CENPO mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CENPO mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CENPO gene27153756
D001280AtrazineAtrazine results in decreased expression of CENPO mRNA22378314
D001374AzacitidineAzacitidine results in increased expression of CENPO mRNA19194470
D004958Estradiol[Dieldrin co-treated with Estradiol] results in decreased expression of CENPO mRNA23041725
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CENPO mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of CENPO mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of CENPO mRNA25181051
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of CENPO mRNA20971185
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CENPO mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of CENPO mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of CENPO mRNA19167446
D000069439DasatinibDasatinib results in decreased expression of CENPO mRNA20579391
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CENPO mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CENPO mRNA21266533
D004026Dieldrin[Dieldrin co-treated with Estradiol] results in decreased expression of CENPO mRNA23041725
D002117CalcitriolCalcitriol results in decreased expression of CENPO mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of CENPO mRNA21592394
C024565ethylene dichlorideethylene dichloride results in decreased expression of CENPO mRNA28189721
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CENPO mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of CENPO mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CENPO mRNA28628672
C544151jinfukangjinfukang results in increased expression of CENPO mRNA27392435
C008261lead acetatelead acetate results in decreased expression of CENPO mRNA22609695
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CENPO mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CENPO mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CENPO mRNA"20188158
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of CENPO mRNA20971185
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CENPO mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of CENPO mRNA23557933
C005556propionaldehydepropionaldehyde results in decreased expression of CENPO mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of CENPO mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of CENPO mRNA19167446
D012715Sesame OilSesame Oil results in decreased expression of CENPO mRNA29191790
C017947sodium arsenitesodium arsenite affects the methylation of CENPO gene28589171
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of CENPO mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of CENPO mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CENPO mRNA22574217
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CENPO mRNA"26179874

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  19447967  25416956  26496610  
GO ID GO Term Qualifier Evidence PubMed
GO:0034080CENP-A containing nucleosome assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000777condensed chromosome kinetochore-IEA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-141424Amplification of signal from the kinetochoresTAS
R-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2500257Resolution of Sister Chromatid CohesionTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-606279Deposition of new CENPA-containing nucleosomes at the centromereTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69618Mitotic Spindle CheckpointTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73886Chromosome MaintenanceTAS
R-HSA-774815Nucleosome assemblyTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28093568GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium. (2017 Mar)Trampush JWMol Psychiatry