Gene: EFHD2

79180
SWS1
EF-hand domain family member D2
protein-coding
1p36.21
Ensembl:ENSG00000142634 MIM:616450 Vega:OTTHUMG00000002254 UniprotKB:Q96C19
NC_000001.11
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.737e-1 (AD)  3.519e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2496320chr1:15417775 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2496321chr1:15417388 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SSBP30.888
SLC25A220.884
CCDC920.878
SNCB0.87
CDC370.863
MAPK8IP20.862
SYN10.861
IFITM100.857
FSD10.855
APBA20.855

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.643
OR4F29-0.622
ASB4-0.383
LRAT-0.351
PON3-0.333
EVA1A-0.318
LHFPL1-0.317
ISL1-0.308
IRX3-0.307
LHX8-0.295

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in decreased phosphorylation of EFHD2 protein"27026707
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of EFHD2 mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of EFHD2 mRNA]"19467301
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of EFHD2 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of EFHD2 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of EFHD2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EFHD2 mRNA]17585979
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of EFHD2 mRNA24449571
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of EFHD2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EFHD2 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EFHD2 mRNA"19150397
D004958EstradiolEstradiol promotes the reaction [EFHD2 protein binds to ESR1 protein]27156127
D004958EstradiolEstradiol results in decreased phosphorylation of EFHD2 protein27026707
C006780bisphenol Abisphenol A results in increased expression of EFHD2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of EFHD2 gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of EFHD2 mRNA27339419
D002273CarcinogensCarcinogens results in decreased expression of EFHD2 mRNA22269147
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of EFHD2 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of EFHD2 mRNA23811191
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EFHD2 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of EFHD2 mRNA19320972
D003300CopperCopper deficiency results in decreased expression of EFHD2 protein25150618
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of EFHD2 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of EFHD2 mRNA19549813
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of EFHD2 mRNA]27941970
D003976DiazinonDiazinon results in increased methylation of EFHD2 gene22964155
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of EFHD2 mRNA]"19467301
D004041Dietary FatsDietary Fats results in decreased expression of EFHD2 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of EFHD2 mRNA19467301|2501614
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of EFHD2 protein23301498
D005472FluorouracilFluorouracil results in decreased expression of EFHD2 mRNA16510598
C069837fullerene C60fullerene C60 results in decreased expression of EFHD2 mRNA19167457
D019833GenisteinGenistein results in decreased methylation of EFHD2 gene28505145
C511402Grape Seed ProanthocyanidinsGrape Seed Proanthocyanidins affects the expression of EFHD2 protein16414080
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of EFHD2 mRNA17183730
C492448ICG 001ICG 001 results in decreased expression of EFHD2 mRNA26191083
D007545IsoproterenolIsoproterenol results in increased expression of EFHD2 mRNA20003209
D008727MethotrexateMethotrexate affects the expression of EFHD2 mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of EFHD2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of EFHD2 mRNA"20188158
C517284monomethyl phthalatemonomethyl phthalate affects the expression of EFHD2 mRNA26924002
C523799MRK 003EFHD2 results in increased susceptibility to MRK 00319903844
D009153MutagensMutagens results in decreased expression of EFHD2 mRNA22269147
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of EFHD2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of EFHD2 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EFHD2 mRNA"25554681
D009532NickelNickel results in increased expression of EFHD2 mRNA24768652|2558310
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of EFHD2 mRNA20971185
D000073878Palm OilPalm Oil results in decreased expression of EFHD2 mRNA18042831
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of EFHD2 protein19854247
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of EFHD2 protein26178269
D010634PhenobarbitalPhenobarbital results in increased expression of EFHD2 mRNA19270015
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of EFHD2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of EFHD2 mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of EFHD2 mRNA18445702
D010936Plant ExtractsPlant Extracts results in decreased expression of EFHD2 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in decreased expression of EFHD2 mRNA24780913
D012643SeleniumSelenium results in increased expression of EFHD2 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of EFHD2 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of EFHD2 mRNA28595984
D012999SomanSoman results in increased expression of EFHD2 mRNA19281266
D053260SootSoot results in increased expression of EFHD2 mRNA26551751
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of EFHD2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to EFHD2 promoter]19654925
C009495titanium dioxidetitanium dioxide results in increased expression of EFHD2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of EFHD2 mRNA20133372
D014212TretinoinTretinoin results in decreased expression of EFHD2 mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of EFHD2 mRNA"26179874
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of EFHD2 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of EFHD2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of EFHD2 mRNA23179753
D014640VancomycinVancomycin results in decreased expression of EFHD2 mRNA18930951
C025643vinclozolinvinclozolin results in increased expression of EFHD2 mRNA23555832
D014810Vitamin EVitamin E results in increased expression of EFHD2 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0045121membrane raft-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal