Gene: TMEM43

79188
ARVC5|ARVD5|EDMD7|LUMA
transmembrane protein 43
protein-coding
3p25.1
Ensembl:ENSG00000170876 MIM:612048 Vega:OTTHUMG00000129802 UniprotKB:Q9BTV4
NG_008975.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.286e-1 (AD)  4.849e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs8516chr3:14143169 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDX50.907
XRN20.906
SSR10.903
RAF10.9
SUPT20H0.897
COPB10.896
KDELR20.891
STT3A0.891
NUP2050.89
NUP980.887

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.658
OR4F29-0.621
HES5-0.198
REN-0.197
KLRC2-0.195
CRH-0.167
RERGL-0.158
OR6C74-0.145
HMHB1-0.139
HPSE2-0.135

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TMEM43 mRNA"25380136
D000082AcetaminophenAcetaminophen affects the expression of TMEM43 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TMEM43 gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in increased expression of TMEM43 protein26072098
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of TMEM43 mRNA21298039
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TMEM43 mRNA21964900|2222880
D004958EstradiolEstradiol affects the expression of TMEM43 mRNA22574217
C006780bisphenol Abisphenol A affects the expression of TMEM43 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TMEM43 mRNA19010381
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TMEM43 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of TMEM43 mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TMEM43 mRNA20938992
D003300Copper[Disulfiram binds to Copper] which results in increased expression of TMEM43 mRNA24690739
D003471CuprizoneCuprizone affects the expression of TMEM43 mRNA27523638
D003471CuprizoneCuprizone results in decreased expression of TMEM43 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of TMEM43 mRNA20106945
C093628cyproconazolecyproconazole results in increased expression of TMEM43 mRNA22334560
D003703DemecolcineDemecolcine results in increased expression of TMEM43 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TMEM43 mRNA21266533
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in decreased expression of TMEM43 mRNA21858171
C000944dicrotophosdicrotophos results in increased expression of TMEM43 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of TMEM43 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of TMEM43 mRNA22609946
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TMEM43 mRNA21607683
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of TMEM43 mRNA25380136
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of TMEM43 mRNA24690739
C109476epoxiconazoleepoxiconazole results in increased expression of TMEM43 mRNA22334560
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TMEM43 mRNA17555576
C024565ethylene dichlorideethylene dichloride results in increased expression of TMEM43 mRNA28189721
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of TMEM43 mRNA21607683
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TMEM43 mRNA20938992
C069837fullerene C60fullerene C60 results in decreased expression of TMEM43 mRNA19167457
D005839GentamicinsGentamicins results in increased expression of TMEM43 mRNA22061828
D017313FenretinideFenretinide results in decreased expression of TMEM43 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TMEM43 mRNA20044591
D007213IndomethacinIndomethacin results in increased expression of TMEM43 mRNA28201806
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TMEM43 mRNA20938992
D008777MethyltestosteroneMethyltestosterone results in decreased expression of TMEM43 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TMEM43 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TMEM43 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of TMEM43 mRNA25380136
D000073878Palm OilPalm Oil results in decreased expression of TMEM43 mRNA18042831
D010656PhenylephrinePhenylephrine results in increased expression of TMEM43 mRNA18158353
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in decreased expression of TMEM43 mRNA21858171
C045950propiconazolepropiconazole results in increased expression of TMEM43 mRNA21278054|2233456
D012969Sodium FluorideSodium Fluoride results in increased expression of TMEM43 protein28918527
D012999SomanSoman results in increased expression of TMEM43 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TMEM43 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TMEM43 mRNA15328365
D013853ThioacetamideThioacetamide results in increased expression of TMEM43 mRNA23411599
D014241TrichloroethyleneTrichloroethylene results in increased expression of TMEM43 mRNA25549359
C025643vinclozolinvinclozolin results in increased expression of TMEM43 mRNA23034163
D014750VincristineVincristine results in increased expression of TMEM43 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of TMEM43 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21391237  25416956  25910212  26871637  
GO:0043621protein self-association-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0071763nuclear membrane organization-IDA18230648  
GO ID GO Term Qualifier Evidence PubMed
GO:0005639integral component of nuclear inner membrane-IEA-  
GO:0005788endoplasmic reticulum lumen-IEA-  
GO:0005794Golgi apparatus-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal