Gene info: ID 7919

Gene: DDX39B

GENE ID: 7919

Synonyms: BAT1|D6S81E|UAP56

Description: DExD-box helicase 39B

Gene type: protein-coding

Location: 6p21.33

dbXrefs: Ensembl:ENSG00000198563 MIM:142560 Vega:OTTHUMG00000031165 UniprotKB:Q13838

RefSeq: NC_000006.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EWSR1	0.94
CHTOP	0.93
RER1	0.93
RBM39	0.928
EIF3D	0.923
HARS2	0.922
IK	0.921
RING1	0.921
CTTN	0.919
HNRNPD	0.919

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.835
OR4F29	-0.814
MTRNR2L6	-0.186
MTRNR2L9	-0.177
HMHB1	-0.154
OR4F16	-0.145
MTRNR2L10	-0.133
C8orf74	-0.122
KRTAP19-1	-0.122
KLRC2	-0.116

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB02325	Isopropyl Alcohol	Small Molecule	67-63-0	Approved\|Investigational	Target
DB11638	Artenimol	Small Molecule	71939-50-9	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DDX39B mRNA"	19114083
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran affects the expression of DDX39B mRNA"	20702594
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of DDX39B mRNA"	19167446
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of DDX39B mRNA"	21346803
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX39B mRNA"	27188386
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of DDX39B mRNA"	21346803
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX39B mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of DDX39B mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of DDX39B mRNA	17562736
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of DDX39B mRNA	16483693
D001151	Arsenic	Arsenic affects the methylation of DDX39B gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in increased expression of DDX39B protein	25419056
D001507	Beclomethasone	Beclomethasone results in increased expression of DDX39B mRNA	23656298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of DDX39B mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of DDX39B mRNA	20127859\|2222880
C006780	bisphenol A	bisphenol A affects the expression of DDX39B mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of DDX39B mRNA	29275510
C006780	bisphenol A	bisphenol A affects the expression of DDX39B mRNA	25181051
C515564	bromovanin	bromovanin results in increased expression of DDX39B protein	21419150
C584509	C646 compound	C646 compound results in decreased expression of DDX39B mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of DDX39B protein	22941245
D002122	Calcium Chloride	Calcium Chloride results in increased expression of DDX39B protein	25824407
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of DDX39B mRNA	27339419
D002273	Carcinogens	Carcinogens results in decreased expression of DDX39B mRNA	22269147
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of DDX39B mRNA	20691718
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of DDX39B mRNA"	19167446
D003471	Cuprizone	Cuprizone results in increased expression of DDX39B mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in increased expression of DDX39B mRNA	19770486
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of DDX39B mRNA	24317228
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of DDX39B mRNA	21266533
D004026	Dieldrin	Dieldrin results in decreased expression of DDX39B mRNA	20584760
D004041	Dietary Fats	Dietary Fats results in decreased expression of DDX39B mRNA	25016146
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of DDX39B protein	28934723
D015127	9,10-Dimethyl-1,2-benzanthracene	"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of DDX39B protein"	22248470
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of DDX39B protein"	22248470
D004147	Dioxins	Dioxins affects the expression of DDX39B mRNA	20463971
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DDX39B protein	23301498
D000431	Ethanol	Ethanol affects the expression of DDX39B mRNA	24355176
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DDX39B mRNA	17942748
D005472	Fluorouracil	Fluorouracil results in increased expression of DDX39B mRNA	16510598
C061365	flusilazole	flusilazole results in decreased expression of DDX39B mRNA	22382673
D005485	Flutamide	Flutamide results in increased expression of DDX39B mRNA	24136188
D005839	Gentamicins	Gentamicins results in increased expression of DDX39B mRNA	22061828
D005897	Glafenine	Glafenine results in increased expression of DDX39B mRNA	24136188
C010974	glyphosate	glyphosate results in increased expression of DDX39B mRNA	26302742
D012701	Serotonin	Serotonin results in decreased expression of DDX39B mRNA	23056638
C492448	ICG 001	ICG 001 results in decreased expression of DDX39B mRNA	26191083
D007213	Indomethacin	Indomethacin results in increased expression of DDX39B mRNA	28201806
D007529	Isoflavones	"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of DDX39B protein"	22248470
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of DDX39B mRNA	26582142
D007657	Ketone Bodies	Ketone Bodies results in increased expression of DDX39B mRNA	16807920
C008261	lead acetate	lead acetate results in decreased expression of DDX39B mRNA	21829687
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of DDX39B mRNA	20353558
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of DDX39B mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of DDX39B mRNA"	25554681\|2562005
D052638	Particulate Matter	Particulate Matter results in increased expression of DDX39B protein	17922515
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of DDX39B mRNA	23892564
D010634	Phenobarbital	Phenobarbital affects the expression of DDX39B mRNA	23091169
D012643	Selenium	Selenium results in decreased expression of DDX39B mRNA	19244175
D012643	Selenium	Selenium results in increased expression of DDX39B mRNA	19244175
C009277	sodium arsenate	sodium arsenate results in increased expression of DDX39B mRNA	23922661
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of DDX39B protein	27548804
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DDX39B mRNA	20702594\|2157046
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DDX39B mRNA	17942748
D013849	Thimerosal	Thimerosal results in decreased expression of DDX39B mRNA	27188386
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDX39B mRNA"	27188386
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of DDX39B mRNA	19042947
D014520	Urethane	Urethane results in decreased expression of DDX39B mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of DDX39B mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of DDX39B mRNA	19101580
C034028	vanadyl sulfate	vanadyl sulfate results in decreased expression of DDX39B mRNA	16330358
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of DDX39B protein	17922515
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of DDX39B gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of DDX39B mRNA	23034163
D014810	Vitamin E	Vitamin E results in decreased expression of DDX39B mRNA	19244175
D014810	Vitamin E	Vitamin E results in increased expression of DDX39B mRNA	19244175
C111237	vorinostat	vorinostat results in decreased expression of DDX39B mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	HDA	22658674 22681889
GO:0004004	ATP-dependent RNA helicase activity	-	IDA	17562711 18593880
GO:0005515	protein binding	-	IPI	11979277 14667819 15047853 15324660 15870275 19836239 21859714 23299939
GO:0005524	ATP binding	-	IEA	-
GO:0008186	RNA-dependent ATPase activity	-	IDA	17562711
GO:0016887	ATPase activity	-	EXP	20844015
GO:0017070	U6 snRNA binding	-	IDA	18593880
GO:0030621	U4 snRNA binding	-	IDA	18593880
GO:0042802	identical protein binding	-	IPI	14667819
GO:0043008	ATP-dependent protein binding	-	IDA	18593880
GO:0044877	protein-containing complex binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000245	spliceosomal complex assembly	-	IDA	18593880
GO:0000398	mRNA splicing, via spliceosome	-	IGI	15047853
GO:0001889	liver development	-	IEA	-
GO:0006405	RNA export from nucleus	-	TAS	-
GO:0006406	mRNA export from nucleus	-	IDA	17190602
GO:0006406	mRNA export from nucleus	-	IGI	15047853
GO:0008380	RNA splicing	-	IDA	18593880
GO:0010501	RNA secondary structure unwinding	-	IDA	18593880
GO:0031124	mRNA 3'-end processing	-	TAS	-
GO:0032786	positive regulation of DNA-templated transcription, elongation	-	IMP	22144908
GO:0045727	positive regulation of translation	-	IEA	-
GO:0046784	viral mRNA export from host cell nucleus	-	IDA	18974867
GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	-	IEA	-
GO:1904707	positive regulation of vascular smooth muscle cell proliferation	-	IEA	-
GO:2000002	negative regulation of DNA damage checkpoint	-	IMP	22144908
GO:2000573	positive regulation of DNA biosynthetic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000346	transcription export complex	-	IDA	15833825 15998806
GO:0005634	nucleus	-	IDA	21859714
GO:0005654	nucleoplasm	-	TAS	-
GO:0005681	spliceosomal complex	-	IDA	18593880
GO:0005687	U4 snRNP	colocalizes_with	IDA	18593880
GO:0005688	U6 snRNP	colocalizes_with	IDA	18593880
GO:0005737	cytoplasm	colocalizes_with	IDA	21859714
GO:0016363	nuclear matrix	-	IEA	-
GO:0016607	nuclear speck	-	IDA	-

KEGG ID	KEGG Term
hsa03013	RNA transport
hsa03015	mRNA surveillance pathway
hsa03040	Spliceosome

Reactome ID	Reactome Term	Evidence
R-HSA-109688	Cleavage of Growing Transcript in the Termination Region	TAS
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	TAS
R-HSA-72187	mRNA 3'-end processing	TAS
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	TAS
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	TAS
R-HSA-73856	RNA Polymerase II Transcription Termination	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8953854	Metabolism of RNA	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29744169	Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents. (2016 Dec)	Heikkinen AM	Clin Exp Dent Res