Gene: IRX3

79191
IRX-1|IRXB1
iroquois homeobox 3
protein-coding
16q12.2
Ensembl:ENSG00000177508 MIM:612985 Vega:OTTHUMG00000133200 UniprotKB:P78415
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.663e-1 (AD)  8.941e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IRX50.79
CRNDE0.786
AGTR10.784
IRX20.784
FEZF10.777
LHX50.776
FAM183A0.77
OTP0.764
FOXB10.76
HMX20.759

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TBR1-0.459
SOHLH1-0.454
TNNT2-0.434
SLC17A7-0.425
NEUROD2-0.423
FEZF2-0.405
RXFP1-0.401
EMX1-0.397
ANKRD24-0.395
TESPA1-0.386

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX3 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of IRX3 gene28458013
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IRX3 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of IRX3 mRNA21298039
D001379AzathioprineAzathioprine results in decreased expression of IRX3 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IRX3 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IRX3 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of IRX3 mRNA25566086
D004958EstradiolEstradiol results in decreased expression of IRX3 mRNA21185374
D004958EstradiolEstradiol results in increased expression of IRX3 mRNA19484750
C006780bisphenol Abisphenol A affects the methylation of IRX3 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of IRX3 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of IRX3 promoter22457795
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRX3 mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IRX3 mRNA]"20230807
D002220CarbamazepineCarbamazepine affects the expression of IRX3 mRNA25979313
D019327Copper SulfateCopper Sulfate results in decreased expression of IRX3 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of IRX3 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of IRX3 mRNA19770486
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of IRX3 mRNA23914054
C014347decitabinedecitabine affects the expression of IRX3 mRNA23300844
D002945CisplatinCisplatin affects the expression of IRX3 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of IRX3 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of IRX3 mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of IRX3 mRNA24535843
D002117CalcitriolCalcitriol results in decreased expression of IRX3 mRNA16002434
C118739entinostatentinostat results in increased expression of IRX3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX3 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of IRX3 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of IRX3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of IRX3 mRNA17942748
D005557FormaldehydeFormaldehyde results in decreased expression of IRX3 mRNA20655997
C069837fullerene C60fullerene C60 results in increased expression of IRX3 mRNA19167457
C039281furanfuran results in decreased expression of IRX3 mRNA27387713
D017313FenretinideFenretinide results in decreased expression of IRX3 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of IRX3 mRNA17183730
C492448ICG 001ICG 001 results in increased expression of IRX3 mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of IRX3 mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of IRX3 mRNA26272509
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX3 mRNA"27188386
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IRX3 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRX3 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IRX3 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRX3 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IRX3 mRNA]"20230807
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of IRX3 mRNA21195148
C028577monobutyl phthalatemonobutyl phthalate affects the expression of IRX3 mRNA21195148
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of IRX3 mRNA29162477
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of IRX3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IRX3 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of IRX3 mRNA19167457
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRX3 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IRX3 mRNA]"20230807
C007350nitrofennitrofen results in increased expression of IRX3 mRNA21238641
C007350nitrofennitrofen results in increased expression of IRX3 protein21238641
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of IRX3 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of IRX3 mRNA25729387
C030110oxaliplatin[Topotecan co-treated with oxaliplatin] results in increased expression of IRX3 mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of IRX3 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX3 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of IRX3 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IRX3 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of IRX3 mRNA23557933
D011794QuercetinQuercetin results in decreased expression of IRX3 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of IRX3 mRNA23806026
D012834SilverSilver results in decreased expression of IRX3 mRNA26014281
D012906SmokeSmoke results in decreased expression of IRX3 mRNA21095227
D014284TriiodothyronineTriiodothyronine results in increased expression of IRX3 mRNA17403546
D013629TamoxifenTamoxifen affects the expression of IRX3 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IRX3 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IRX3 mRNA24058054|2892240
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of IRX3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IRX3 mRNA17586704|1977048
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of IRX3 mRNA25729387
D019772Topotecan[Topotecan co-treated with oxaliplatin] results in increased expression of IRX3 mRNA25729387
D019772TopotecanTopotecan results in increased expression of IRX3 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of IRX3 mRNA17218384
D014212TretinoinTretinoin results in increased expression of IRX3 mRNA21934132
D014212TretinoinTretinoin results in increased expression of IRX3 mRNA16604517
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX3 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of IRX3 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of IRX3 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of IRX3 mRNA12732648
C057693troglitazone[troglitazone co-treated with TNF protein] results in decreased expression of IRX3 mRNA12732648
D014520UrethaneUrethane results in decreased expression of IRX3 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of IRX3 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IRX3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of IRX3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of IRX3 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of IRX3 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of IRX3 gene29154799
C025643vinclozolinvinclozolin affects the expression of IRX3 mRNA19015723
C088658zoledronic acidzoledronic acid results in decreased expression of IRX3 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0043565sequence-specific DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001656metanephros development-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0007498mesoderm development-IEA-  
GO:0045665negative regulation of neuron differentiation-IEA-  
GO:0045666positive regulation of neuron differentiation-IEA-  
GO:0072086specification of loop of Henle identity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IEA-  
GO:0030424axon-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26878930Evaluation of the acute changes in objective accommodation, pupil size and ocular wavefront aberrations after cigarette smoking. (2017 Mar)Bardak HCutan Ocul Toxicol