Gene: MMEL1

79258
MMEL2|NEP2|NEPII|NL1|NL2|SEP
membrane metalloendopeptidase like 1
protein-coding
1p36.32
Ensembl:ENSG00000142606 Vega:OTTHUMG00000000846 UniprotKB:Q495T6
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.311e-1 (AD)  8.292e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MUC10.76
C4B0.74
TMPRSS30.736
LIMK20.736
C4A0.713
PODNL10.711
DSC20.71
MR10.693
C1S0.691
TMCO40.68

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPLX3-0.467
KCNIP3-0.442
ADRA1D-0.43
EYA4-0.429
NEUROD6-0.427
PPEF1-0.426
CRH-0.423
ABCC12-0.423
KIT-0.407
HR-0.4

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of MMEL1 mRNA16788091
D001151ArsenicArsenic affects the methylation of MMEL1 gene25304211
C006780bisphenol Abisphenol A results in decreased methylation of MMEL1 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of MMEL1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MMEL1 mRNA24982889
C060942candoxatrilatcandoxatrilat results in decreased activity of MMEL1 protein18084312
D003471CuprizoneCuprizone results in decreased expression of MMEL1 mRNA26577399
D003520CyclophosphamideCyclophosphamide results in increased expression of MMEL1 mRNA27281708
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MMEL1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MMEL1 mRNA17942748
C039281furanfuran results in decreased expression of MMEL1 mRNA25539665
C544151jinfukangjinfukang results in increased expression of MMEL1 mRNA27392435
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of MMEL1 mRNA22401849
C517284monomethyl phthalatemonomethyl phthalate affects the expression of MMEL1 mRNA26924002
C031721naphthalenenaphthalene analog results in decreased expression of MMEL1 mRNA24976557
C106266omapatrilatomapatrilat results in decreased activity of MMEL1 protein18084312
C005556propionaldehydepropionaldehyde results in decreased expression of MMEL1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of MMEL1 mRNA24780913
D012999SomanSoman results in decreased expression of MMEL1 mRNA19281266
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MMEL1 mRNA17942748
D014403TubocurarineTubocurarine results in decreased expression of MMEL1 mRNA19728367
D014635Valproic AcidValproic Acid affects the expression of MMEL1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of MMEL1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MMEL1 gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of MMEL1 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20439292Genetic variants in the prediction of rheumatoid arthritis. (2010 Sep)van der Helm-van Mil AHAnn Rheum Dis