Gene: NELFE

7936
D6S45|NELF-E|RD|RDBP|RDP
negative elongation factor complex member E
protein-coding
6p21.33
Ensembl:ENSG00000204356 MIM:154040 Vega:OTTHUMG00000031046 UniprotKB:P18615
NC_000006.12
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs419788chr6:31961022 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs630379chr6:31954477 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KXD10.919
RNF1810.919
UBXN10.917
SSR40.917
TALDO10.914
U2AF10.907
EIF3G0.906
RALY0.904
PSMD90.901
CHMP2A0.899

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.767
OR4F5-0.763
MTRNR2L6-0.217
MTRNR2L9-0.199
C8orf74-0.15
EPPIN-0.15
MTRNR2L10-0.149
KRTAP4-8-0.149
SPRR4-0.147
OR4F16-0.146

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of NELFE mRNA"22698814
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NELFE mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NELFE mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of NELFE mRNA"18648102
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of NELFE mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of NELFE mRNA25064622
D000082AcetaminophenAcetaminophen results in increased expression of NELFE mRNA25704631
D000638AmiodaroneAmiodarone affects the expression of NELFE mRNA25064622
D001151ArsenicArsenic affects the methylation of NELFE gene25304211
C006780bisphenol Abisphenol A affects the expression of NELFE mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of NELFE mRNA25181051
D002746ChlorpromazineChlorpromazine affects the expression of NELFE mRNA25064622
C018021cobaltous chloridecobaltous chloride results in decreased expression of NELFE mRNA19320972|1937684
D016572CyclosporineCyclosporine affects the expression of NELFE mRNA25064622
D016572CyclosporineCyclosporine results in increased expression of NELFE mRNA20106945|2798913
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NELFE mRNA21266533
D004041Dietary FatsDietary Fats results in decreased expression of NELFE mRNA18042831
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of NELFE mRNA27638505
D004147DioxinsDioxins affects the expression of NELFE mRNA20463971
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of NELFE protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NELFE mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NELFE mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NELFE mRNA17942748
D019833GenisteinGenistein promotes the reaction [NELFE protein binds to ESR1 protein]27156127
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of NELFE mRNA19376150
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NELFE mRNA25613284
D007854LeadLead results in decreased expression of NELFE mRNA19921347
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of NELFE mRNA23458150
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NELFE mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NELFE mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in decreased expression of NELFE mRNA29191790
D010100OxygenOxygen deficiency results in decreased expression of NELFE mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in decreased expression of NELFE mRNA]22629407
D000073878Palm OilPalm Oil results in decreased expression of NELFE mRNA18042831
D010269ParaquatParaquat affects the expression of NELFE mRNA25064622
D010634PhenobarbitalPhenobarbital affects the expression of NELFE mRNA23091169
D011794QuercetinQuercetin results in increased expression of NELFE mRNA21632981
D012715Sesame OilSesame Oil results in increased expression of NELFE mRNA29191790
D013629TamoxifenTamoxifen results in increased expression of NELFE mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NELFE mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NELFE mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NELFE promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NELFE mRNA21354282
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of NELFE protein23298284
D013752TetracyclineTetracycline affects the expression of NELFE mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NELFE mRNA25613284
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of NELFE protein20109541
D013853ThioacetamideThioacetamide affects the expression of NELFE mRNA25064622
D014241TrichloroethyleneTrichloroethylene results in increased expression of NELFE mRNA19448997
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of NELFE mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of NELFE mRNA25064622
D014635Valproic AcidValproic Acid results in increased expression of NELFE mRNA29154799
C025643vinclozolinvinclozolin results in decreased expression of NELFE mRNA21126777

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IEA-  
GO:0003723RNA binding-HDA22658674  
GO:0003723RNA binding-NAS2119325  
GO:0005515protein binding-IPI12612062  14667819  25416956  26496610  
GO ID GO Term Qualifier Evidence PubMed
GO:0006366transcription by RNA polymerase II-TAS-  
GO:0006368transcription elongation from RNA polymerase II promoter-TAS-  
GO:0034244negative regulation of transcription elongation from RNA polymerase II promoter-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0051571positive regulation of histone H3-K4 methylation-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IEA-  
GO:1900364negative regulation of mRNA polyadenylation-IMP19575011  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-NAS2119325  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0016604nuclear body-IDA-  
GO:0032021NELF complex-IDA12612062  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112382Formation of RNA Pol II elongation complex TAS
R-HSA-113418Formation of the Early Elongation ComplexTAS
R-HSA-162587HIV Life CycleIEA
R-HSA-162587HIV Life CycleTAS
R-HSA-162599Late Phase of HIV Life CycleIEA
R-HSA-162599Late Phase of HIV Life CycleTAS
R-HSA-162906HIV InfectionIEA
R-HSA-162906HIV InfectionTAS
R-HSA-1643685DiseaseIEA
R-HSA-1643685DiseaseTAS
R-HSA-167152Formation of HIV elongation complex in the absence of HIV TatIEA
R-HSA-167158Formation of the HIV-1 Early Elongation ComplexIEA
R-HSA-167169HIV Transcription ElongationIEA
R-HSA-167169HIV Transcription ElongationTAS
R-HSA-167172Transcription of the HIV genomeIEA
R-HSA-167172Transcription of the HIV genomeTAS
R-HSA-167200Formation of HIV-1 elongation complex containing HIV-1 TatTAS
R-HSA-167200Formation of HIV-1 elongation complex containing HIV-1 TatIEA
R-HSA-167238Pausing and recovery of Tat-mediated HIV elongationIEA
R-HSA-167242Abortive elongation of HIV-1 transcript in the absence of TatIEA
R-HSA-167243Tat-mediated HIV elongation arrest and recoveryIEA
R-HSA-167246Tat-mediated elongation of the HIV-1 transcriptIEA
R-HSA-167246Tat-mediated elongation of the HIV-1 transcriptTAS
R-HSA-167287HIV elongation arrest and recoveryIEA
R-HSA-167290Pausing and recovery of HIV elongationIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5663205Infectious diseaseIEA
R-HSA-5663205Infectious diseaseTAS
R-HSA-674695RNA Polymerase II Pre-transcription EventsTAS
R-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-75955RNA Polymerase II Transcription ElongationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal