Gene: BHLHE41

79365
BHLHB3|DEC2|SHARP1|hDEC2
basic helix-loop-helix family member e41
protein-coding
12p12.1
Ensembl:ENSG00000123095 MIM:606200 Vega:OTTHUMG00000169174 UniprotKB:Q9C0J9
NG_021173.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.098e-1 (AD)  8.079e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CREG10.783
DDX50.764
PICALM0.764
CAPZA10.763
CD1640.761
XRN20.754
TMED100.752
SDCBP0.75
ZFAND60.747
HSD17B110.746

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.611
OR4F29-0.569
HES5-0.199
OR51A2-0.176
CRH-0.165
ST8SIA2-0.163
GGN-0.159
TLX3-0.155
RNASE8-0.155
CRLF2-0.154

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0005915411-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of BHLHE41 mRNA]"24403227
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BHLHE41 mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of BHLHE41 mRNA"19095052
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of BHLHE41 mRNA"23146750
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of BHLHE41 mRNA"23196670
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of BHLHE41 mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE41 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of BHLHE41 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE41 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of BHLHE41 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of BHLHE41 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of BHLHE41 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of BHLHE41 gene27153756
D000447AldehydesAldehydes results in increased expression of BHLHE41 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BHLHE41 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of BHLHE41 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of BHLHE41 mRNA"24160326
D001507BeclomethasoneBeclomethasone results in increased expression of BHLHE41 mRNA23656298
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of BHLHE41 mRNA18164116
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of BHLHE41 mRNA20660070
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of BHLHE41 mRNA17404688
C095105bexarotenebexarotene results in decreased expression of BHLHE41 mRNA16648578
C006780bisphenol Abisphenol A affects the expression of BHLHE41 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of BHLHE41 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of BHLHE41 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of BHLHE41 mRNA26079696
C006884cannabidiolic acidcannabidiolic acid results in increased expression of BHLHE41 mRNA25242400
D002509CephaloridineCephaloridine results in increased expression of BHLHE41 mRNA18500788
D002737ChloropreneChloroprene results in increased expression of BHLHE41 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BHLHE41 gene20938992
D002995Clofibric AcidClofibric Acid affects the expression of BHLHE41 mRNA17602206
D003907DexamethasoneDexamethasone results in decreased expression of BHLHE41 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of BHLHE41 mRNA]20032058
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of BHLHE41 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of BHLHE41 mRNA27392435
D002945Cisplatin[Cisplatin co-treated with panobinostat] affects the expression of BHLHE41 mRNA21791302
D002945CisplatinCisplatin results in decreased expression of BHLHE41 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of BHLHE41 mRNA22023808
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of BHLHE41 mRNA26924002
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of BHLHE41 mRNA27614199
C014476diethyl maleatediethyl maleate results in decreased expression of BHLHE41 mRNA21161181
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of BHLHE41 mRNA18164116
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of BHLHE41 mRNA23876855
D004237DiuronDiuron results in decreased expression of BHLHE41 mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of BHLHE41 mRNA15576828
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of BHLHE41 mRNA17351261
C540355fenamidonefenamidone results in increased expression of BHLHE41 mRNA27029645
D005472FluorouracilBHLHE41 protein affects the susceptibility to Fluorouracil16217747
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BHLHE41 gene20938992
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of BHLHE41 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of BHLHE41 mRNA24796395
D007649KetamineKetamine results in increased expression of BHLHE41 mRNA20080153
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of BHLHE41 mRNA25890327
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BHLHE41 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of BHLHE41 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of BHLHE41 mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of BHLHE41 mRNA16026605
C059539midostaurinmidostaurin results in decreased expression of BHLHE41 mRNA20980353
C517284monomethyl phthalatemonomethyl phthalate affects the expression of BHLHE41 mRNA26924002
C523799MRK 003MRK 003 results in decreased expression of BHLHE41 mRNA21169257
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of BHLHE41 mRNA"25554681
D009532NickelNickel results in decreased expression of BHLHE41 mRNA24768652
C022838nickel chloridenickel chloride affects the expression of BHLHE41 mRNA22110744
C028007nickel monoxidenickel monoxide results in increased expression of BHLHE41 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of BHLHE41 mRNA25729387
C005290oxybenzoneoxybenzone results in decreased expression of BHLHE41 mRNA22721600
D010100Oxygen"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of BHLHE41 mRNA]"24403227
D010100OxygenOxygen deficiency results in increased expression of BHLHE41 mRNA24236059|2440322
C496932panobinostat[Cisplatin co-treated with panobinostat] affects the expression of BHLHE41 mRNA21791302
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of BHLHE41 mRNA19095052
C046012pentanalpentanal results in increased expression of BHLHE41 mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of BHLHE41 mRNA27614199
D010634PhenobarbitalPhenobarbital affects the expression of BHLHE41 mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHLHE41 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of BHLHE41 mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in increased expression of BHLHE41 mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of BHLHE41 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of BHLHE41 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of BHLHE41 mRNA20726854
C005556propionaldehydepropionaldehyde results in increased expression of BHLHE41 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of BHLHE41 mRNA24780913
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of BHLHE41 mRNA"24160326
C009250sevofluranesevoflurane affects the expression of BHLHE41 mRNA15967596
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of BHLHE41 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of BHLHE41 mRNA22300531|2535159
D012822Silicon DioxideSilicon Dioxide results in increased expression of BHLHE41 mRNA22431001
D012999SomanSoman results in increased expression of BHLHE41 mRNA19281266
C501413tesaglitazartesaglitazar results in increased expression of BHLHE41 mRNA21515302
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of BHLHE41 mRNA]20032058
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of BHLHE41 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BHLHE41 mRNA16714409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BHLHE41 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BHLHE41 mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BHLHE41 mRNA22808131
D013853ThioacetamideThioacetamide results in increased expression of BHLHE41 mRNA23411599
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of BHLHE41 mRNA25729387
D019772TopotecanTopotecan results in increased expression of BHLHE41 mRNA25729387
C011559tributyltintributyltin results in decreased expression of BHLHE41 mRNA27614199
D014241TrichloroethyleneTrichloroethylene results in increased expression of BHLHE41 mRNA28973375
C057693troglitazonetroglitazone results in increased expression of BHLHE41 mRNA21515302
C022884undecaneundecane results in increased expression of BHLHE41 protein17337753
D014638VanadatesVanadates results in increased expression of BHLHE41 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of BHLHE41 gene25560391
D001335Vehicle EmissionsVehicle Emissions analog results in increased expression of BHLHE41 mRNA15541757
D001335Vehicle EmissionsVehicle Emissions results in increased expression of BHLHE41 mRNA19165385
C025643vinclozolinvinclozolin results in increased expression of BHLHE41 mRNA22615374|2303416
C111237vorinostatvorinostat results in decreased expression of BHLHE41 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-ISS-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-ISS-  
GO:0001102RNA polymerase II activating transcription factor binding-ISS-  
GO:0001191transcriptional repressor activity, RNA polymerase II transcription factor binding-ISS-  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-ISS-  
GO:0003714transcription corepressor activity-IBA21873635  
GO:0003714transcription corepressor activity-IDA19786558  
GO:0005515protein binding-IPI19786558  22801492  
GO:0008134transcription factor binding-IBA21873635  
GO:0042803protein homodimerization activity-ISS-  
GO:0042826histone deacetylase binding-ISS-  
GO:0043425bHLH transcription factor binding-IPI15193144  
GO:0043425bHLH transcription factor binding-ISS-  
GO:0043426MRF binding-ISS-  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0046982protein heterodimerization activity-IPI15193144  
GO:0046982protein heterodimerization activity-ISS-  
GO:0070888E-box binding-IDA14672706  15193144  
GO:0070888E-box binding-ISS-  
GO:1990837sequence-specific double-stranded DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA14672706  15193144  
GO:0001756somitogenesis-IBA21873635  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007219Notch signaling pathway-IBA21873635  
GO:0008283cell proliferation-NAS11162494  
GO:0009887animal organ morphogenesis-NAS11162494  
GO:0010832negative regulation of myotube differentiation-ISS-  
GO:0010944negative regulation of transcription by competitive promoter binding-ISS-  
GO:0030154cell differentiation-IBA21873635  
GO:0030154cell differentiation-NAS11162494  
GO:0032922circadian regulation of gene expression-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0050767regulation of neurogenesis-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
hsa04710Circadian rhythm
Reactome ID Reactome Term Evidence
R-HSA-1368108BMAL1:CLOCK,NPAS2 activates circadian gene expressionIEA
R-HSA-400253Circadian ClockIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26446021Possible involvement of the circadian pathway in alcohol use disorder in a South African adolescent cohort. (2016 Feb)Dalvie SMetab Brain Dis