Gene: PLA2G7

7941
LDL-PLA2|LP-PLA2|PAFAD|PAFAH
phospholipase A2 group VII
protein-coding
6p12.3
Ensembl:ENSG00000146070 MIM:601690 Vega:OTTHUMG00000014789 UniprotKB:Q13093
NG_016204.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
10   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.291e-3 (AD)  3.834e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3799861chr6:46721792 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEXB0.732
PLAA0.721
LGMN0.721
LGALS80.719
ERICH10.714
MGAT4A0.713
TMTC10.707
MTHFD1L0.707
SLC17A50.706
GRB20.703

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MTRNR2L6-0.341
MTRNR2L9-0.316
PYGM-0.307
MTRNR2L10-0.307
OR4F5-0.301
KLRB1-0.297
PON1-0.297
S100A1-0.295
C9orf153-0.292
SLC25A48-0.29

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05119RilapladibSmall Molecule412950-08-4InvestigationalTarget
DB07821(1R)-1,2,2-trimethylpropyl (R)-methylphosphinateSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of PLA2G7 mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of PLA2G7 mRNA]"27071940
C0365351,6-bis(cyclohexyloximinocarbonyl)hexane"1,6-bis(cyclohexyloximinocarbonyl)hexane results in decreased activity of PLA2G7 protein"18657971
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PLA2G7 mRNA"25614096
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PLA2G7 mRNA]"21432021
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PLA2G7 mRNA"19114083
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of PLA2G7 mRNA28522335
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G7 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of PLA2G7 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G7 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PLA2G7 mRNA17562736
C109238acylineacyline results in increased expression of PLA2G7 mRNA17510436
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PLA2G7 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PLA2G7 mRNA23630614
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of PLA2G7 mRNA28522335
D001152ArsenicalsArsenicals results in decreased expression of PLA2G7 mRNA28625800
C547126AZM551248AZM551248 results in increased expression of PLA2G7 mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of PLA2G7 mRNA26377693
D001554BenzeneBenzene results in increased expression of PLA2G7 mRNA19162166
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PLA2G7 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PLA2G7 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLA2G7 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PLA2G7 mRNA20713471|2222880
C063964bepafant"bepafant inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PLA2G7 mRNA]"21432021
C063964bepafantbepafant inhibits the reaction [Platelet Activating Factor results in increased expression of PLA2G7 mRNA]21432021
D004958EstradiolEstradiol results in decreased expression of PLA2G7 mRNA19429434
C006780bisphenol Abisphenol A results in increased expression of PLA2G7 mRNA25181051
C064509BN 50739"BN 50739 inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PLA2G7 mRNA]"21432021
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PLA2G7 mRNA15336504
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PLA2G7 mRNA14729362|1533650
D002101Cacodylic AcidCacodylic Acid results in increased expression of PLA2G7 mRNA17441966
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PLA2G7 mRNA23741332
D002220CarbamazepineCarbamazepine affects the expression of PLA2G7 mRNA25979313
D002248Carbon MonoxideCarbon Monoxide affects the expression of PLA2G721356620
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PLA2G7 mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PLA2G7 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLA2G7 mRNA20938992
D003033Coal TarCoal Tar results in increased expression of PLA2G7 mRNA27858113
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in decreased expression of PLA2G7 mRNA18078969
C018021cobaltous chloridecobaltous chloride results in increased expression of PLA2G7 mRNA24612858
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of PLA2G7 mRNA20971185
D003471CuprizoneCuprizone results in increased expression of PLA2G7 mRNA27523638
D004008DiclofenacDiclofenac results in increased expression of PLA2G7 mRNA26934552
D004041Dietary FatsDietary Fats affects the expression of PLA2G7 mRNA19680557
D019422Dietary SucroseDietary Sucrose results in increased expression of PLA2G7 mRNA26033743
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PLA2G7 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of PLA2G7 mRNA28943392
D002117CalcitriolCalcitriol results in decreased expression of PLA2G7 mRNA26485663
D004318DoxycyclineDoxycycline inhibits the reaction [Isoproterenol results in increased expression of PLA2G7 mRNA]18089841
C118739entinostatentinostat results in increased expression of PLA2G7 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G7 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PLA2G7 mRNA17555576
C024565ethylene dichlorideethylene dichloride results in increased expression of PLA2G7 mRNA28189721
D000069438Ezetimibe[orlistat co-treated with Ezetimibe] results in decreased activity of PLA2G7 protein18513463
D011345FenofibrateFenofibrate results in decreased activity of PLA2G7 protein16911813
D011345Fenofibrate[orlistat co-treated with Fenofibrate] results in decreased activity of PLA2G7 protein16911813
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLA2G7 mRNA20938992
D004397FonofosFonofos results in increased methylation of PLA2G7 promoter22847954
C039281furanfuran results in increased expression of PLA2G7 mRNA26194646|2738771
D017313FenretinideFenretinide results in increased expression of PLA2G7 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PLA2G7 mRNA14729362
C016517indole-3-carbinolindole-3-carbinol affects the expression of PLA2G7 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PLA2G7 mRNA25613284
D007545IsoproterenolDoxycycline inhibits the reaction [Isoproterenol results in increased expression of PLA2G7 mRNA]18089841
D007545IsoproterenolIsoproterenol results in increased expression of PLA2G7 mRNA18089841|2000320
C440499lipopolysaccharide, Escherichia coli O111 B4"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PLA2G7 mRNA]"21432021
C440499lipopolysaccharide, Escherichia coli O111 B4"bepafant inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PLA2G7 mRNA]"21432021
C440499lipopolysaccharide, Escherichia coli O111 B4"BN 50739 inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PLA2G7 mRNA]"21432021
C440499lipopolysaccharide, Escherichia coli O111 B4"[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Platelet Activating Factor] results in increased expression of PLA2G7 mRNA"21432021
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PLA2G7 mRNA"21432021
C440499lipopolysaccharide, Escherichia coli O111 B4"SB 203580 inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PLA2G7 mRNA]"21432021
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of and results in increased activity of PLA2G7 protein21176638
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PLA2G7 mRNA21176638
D008070LipopolysaccharidesSB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G7 protein]21176638
D008070LipopolysaccharidesSimvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PLA2G7 protein]21176638
D008070LipopolysaccharidesSimvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G7 mRNA]21176638
D008070LipopolysaccharidesLipopolysaccharides results in increased activity of PLA2G7 mRNA10409262
D008070LipopolysaccharidesLipopolysaccharides results in increased activity of PLA2G7 protein10409262
D008070LipopolysaccharidesLipopolysaccharides results in increased activity of PLA2G7 protein10409262
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PLA2G7 mRNA27339419
D008070LipopolysaccharidesLipopolysaccharides results in increased activity of PLA2G7 protein10409262
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PLA2G7 mRNA10409262
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLA2G7 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of PLA2G7 mRNA20713471
C523799MRK 003PLA2G7 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of PLA2G7 mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PLA2G7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PLA2G7 mRNA"25554681|2562005
D009525NiacinNiacin results in decreased expression of PLA2G7 protein16950175
D009532NickelNickel results in decreased expression of PLA2G7 mRNA24768652
D009532NickelNickel results in increased expression of PLA2G7 mRNA12540486
D009585Nitrogen DioxideNitrogen Dioxide affects the expression of PLA2G721356620
D009609Nitrous OxideNitrous Oxide affects the expression of PLA2G721356620
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of PLA2G7 mRNA20971185
C055122orlistat[orlistat co-treated with Ezetimibe] results in decreased activity of PLA2G7 protein18513463
C055122orlistat[orlistat co-treated with Fenofibrate] results in decreased activity of PLA2G7 protein16911813
C055122orlistatorlistat results in decreased activity of PLA2G7 protein16911813|1851346
D010126OzoneOzone affects the expression of PLA2G721356620
D010126OzoneOzone results in decreased expression of PLA2G7 mRNA12763052
D000073878Palm OilPalm Oil affects the expression of PLA2G7 mRNA19680557
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G7 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PLA2G7 mRNA26272509
D010278ParathionParathion results in increased methylation of PLA2G7 promoter22847954
D052638Particulate MatterParticulate Matter affects the expression of PLA2G721356620
C046012pentanalpentanal results in increased expression of PLA2G7 mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PLA2G7 mRNA17681415
C006253pirinixic acidpirinixic acid results in increased expression of PLA2G7 mRNA17950772|1830175
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of PLA2G7 mRNA]17950772|2005976
D010972Platelet Activating Factorbepafant inhibits the reaction [Platelet Activating Factor results in increased expression of PLA2G7 mRNA]21432021
D010972Platelet Activating Factor"[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Platelet Activating Factor] results in increased expression of PLA2G7 mRNA"21432021
D010972Platelet Activating FactorPlatelet Activating Factor results in increased expression of PLA2G7 mRNA21432021
D011374ProgesteroneProgesterone results in increased expression of PLA2G7 mRNA23012394
D011374ProgesteroneProgesterone results in decreased expression of PLA2G7 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in decreased expression of PLA2G7 mRNA24780913
D011794QuercetinQuercetin affects the expression of PLA2G7 mRNA18178720
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of PLA2G7 mRNA19429434
D015474IsotretinoinIsotretinoin results in decreased expression of PLA2G7 mRNA20436886
C093642SB 203580"SB 203580 inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PLA2G7 mRNA]"21432021
C093642SB 203580SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G7 protein]21176638
D019821SimvastatinSimvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PLA2G7 protein]21176638
D019821SimvastatinSimvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G7 mRNA]21176638
C016104sodium bichromatesodium bichromate results in decreased expression of PLA2G7 mRNA17685462
D013458Sulfur DioxideSulfur Dioxide affects the expression of PLA2G721356620
C013698tallowtallow affects the expression of PLA2G7 mRNA19680557
D013629TamoxifenTamoxifen results in decreased expression of PLA2G7 mRNA19429434
D013629TamoxifenTamoxifen affects the expression of PLA2G7 mRNA17555576|2093736
C012568terbufosterbufos results in increased methylation of PLA2G7 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PLA2G7 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PLA2G7 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of PLA2G7 mRNA25975270
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PLA2G7 mRNA25613284
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of PLA2G7 mRNA28943392
D013853ThioacetamideThioacetamide results in increased expression of PLA2G7 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of PLA2G7 gene26756918
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PLA2G7 mRNA20133372
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G7 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PLA2G7 mRNA24935251|2627250
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of PLA2G7 mRNA17982090
D014303TrinitrotolueneTrinitrotoluene affects the expression of PLA2G7 mRNA21346803
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in decreased expression of PLA2G7 mRNA18078969
D014425TurpentineTurpentine results in increased activity of PLA2G7 protein10409262
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G7 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PLA2G7 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PLA2G7 mRNA23179753|2352703
D014640VancomycinVancomycin results in decreased expression of PLA2G7 mRNA18930951
C029297vinylidene chloridevinylidene chloride results in increased expression of PLA2G7 mRNA26682919
D024483Vitamin K 3Vitamin K 3 results in increased expression of PLA2G7 mRNA25270620
D015054ZymosanZymosan results in increased activity of PLA2G7 protein10409262

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038471-alkyl-2-acetylglycerophosphocholine esterase activity-IBA21873635  
GO:00038471-alkyl-2-acetylglycerophosphocholine esterase activity-IDA8624782  
GO:0005543phospholipid binding-IDA8624782  
GO:0016788hydrolase activity, acting on ester bonds-TAS-  
GO:0047499calcium-independent phospholipase A2 activity-IDA8624782  
GO ID GO Term Qualifier Evidence PubMed
GO:0016042lipid catabolic process-IEA-  
GO:0034374low-density lipoprotein particle remodeling-IDA8624782  
GO:0034440lipid oxidation-IDA8624782  
GO:0034441plasma lipoprotein particle oxidation-IDA8624782  
GO:0046469platelet activating factor metabolic process-IDA8624782  
GO:0050729positive regulation of inflammatory response-TAS8624782  
GO:0090026positive regulation of monocyte chemotaxis-IDA8624782  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005737cytoplasm-IEA-  
GO:0034362low-density lipoprotein particle-IDA8624782  
KEGG ID KEGG Term
hsa00565Ether lipid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-422085Synthesis, secretion, and deacylation of GhrelinTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23555769Elevated PLA2G7 gene promoter methylation as a gender-specific marker of aging increases the risk of coronary heart disease in females. (2013)Jiang DPLoS One
29728838Interaction between nonsynonymous polymorphisms in PLA2G7 gene and smoking on the risk of coronary heart disease in a Chinese population. (2018 May 4)Chi YJ Thromb Thrombolysis
20442857Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study. (2010 Apr 29)Suchindran SPLoS Genet
22003152Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies. (2012 Jan)Grallert HEur Heart J
17137217Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. (2006 Aug)Kokubo YHypertens Res
19948975Integrative predictive model of coronary artery calcification in atherosclerosis. (2009 Dec 15)McGeachie MCirculation
21490708Carriage of the V279F null allele within the gene encoding Lp-PLA(2) is protective from coronary artery disease in South Korean males. (2011 Apr 5)Jang YPLoS One
25690150Nonsynonymous polymorphisms in PLA2G7 gene are associated with the risk of coronary heart disease in a southern Chinese population. (2015 Apr)Hong MMamm Genome
21834908Association between lipoprotein-associated phospholipase A2 gene polymorphism and coronary artery disease in the Chinese Han population. (2011 Sep)Li LAnn Hum Genet
16308493Vasospastic angina and microvascular angina are differentially influenced by PON1 A632G polymorphism in the Japanese. (2005 Dec)Mashiba JCirc J