Gene: ZBED2

79413
-
zinc finger BED-type containing 2
protein-coding
3q13.13
Ensembl:ENSG00000177494 MIM:615246 Vega:OTTHUMG00000074061 UniprotKB:Q9BTP6
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.535e-1 (AD)  8.369e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENTHD10.949
DRD30.936
GPR1010.93
SAG0.921
AMBN0.92
DGKK0.907
TMPRSS60.901
GPR10.894
CHAT0.885
TNFRSF80.881

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC17A7-0.44
GALNT9-0.399
NEUROD2-0.371
SOHLH1-0.369
NXPH3-0.367
SYTL2-0.364
NANOS3-0.356
TESPA1-0.352
TBR1-0.347
TNNT2-0.344

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000447AldehydesAldehydes results in increased expression of ZBED2 mRNA25014914
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ZBED2 mRNA21298039
D016718Arachidonic AcidArachidonic Acid results in decreased expression of ZBED2 mRNA16704987
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of ZBED2 mRNA"25351596
D004958EstradiolEstradiol results in decreased expression of ZBED2 mRNA23019147
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of ZBED2 mRNA17404688
C018475butyraldehydebutyraldehyde results in increased expression of ZBED2 mRNA26079696
C100187chloropicrinchloropicrin results in increased expression of ZBED2 mRNA26352163
D016572CyclosporineCyclosporine results in increased methylation of ZBED2 promoter27989131
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ZBED2 mRNA21527772
D004397FonofosFonofos results in increased methylation of ZBED2 promoter22847954
D005557FormaldehydeFormaldehyde results in increased expression of ZBED2 mRNA27664576
D019833GenisteinGenistein results in decreased expression of ZBED2 mRNA23019147
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ZBED2 mRNA26752646
D010278ParathionParathion results in increased methylation of ZBED2 promoter22847954
C046012pentanalpentanal results in increased expression of ZBED2 mRNA26079696
D010634PhenobarbitalPhenobarbital results in decreased expression of ZBED2 mRNA19084549
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of ZBED2 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of ZBED2 mRNA21540246
D011374ProgesteroneProgesterone results in increased expression of ZBED2 mRNA17404688|1807036
C005556propionaldehydepropionaldehyde results in increased expression of ZBED2 mRNA26079696
D012822Silicon DioxideSilicon Dioxide results in increased expression of ZBED2 mRNA25351596
C017947sodium arsenitesodium arsenite results in decreased expression of ZBED2 mRNA23876855
C017947sodium arsenitesodium arsenite results in decreased methylation of ZBED2 gene24570342
C017947sodium arsenitesodium arsenite results in increased expression of ZBED2 mRNA24570342
C012568terbufosterbufos results in increased methylation of ZBED2 promoter22847954
C034613triacsin Ctriacsin C results in decreased expression of ZBED2 mRNA16704987
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ZBED2 gene25487561

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0003677DNA binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24419231Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data. (2014 May)Tang HCarcinogenesis