Gene: NKAIN1

79570
FAM77C
sodium/potassium transporting ATPase interacting 1
protein-coding
1p35.2
Ensembl:ENSG00000084628 MIM:612871 Vega:OTTHUMG00000003788 UniprotKB:Q4KMZ8
NC_000001.11
PubMed
0   ANCO-SNPs
AD
2   
3.849e-1 (AD)  3.649e-1 (ND)   (Frontal_Cortex)
2.971e-3 (AD)  2.676e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NFASC0.811
ARHGEF20.79
ATG16L10.787
NACAD0.786
RASAL10.785
DUSP70.784
AGPAT40.776
MPP20.776
HID10.774
LGI30.772

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GJB2-0.467
RNF135-0.416
PON3-0.405
PHEX-0.403
ASB4-0.398
WEE1-0.396
SIX1-0.395
IL18RAP-0.392
OR4F5-0.387
ZIC5-0.385

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of NKAIN1 mRNA28329830
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of NKAIN1 mRNA"21920950
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of NKAIN1 mRNA"25710175
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NKAIN1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NKAIN1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of NKAIN1 gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of NKAIN1 mRNA28522335
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NKAIN1 mRNA20106945|2163298
C006780bisphenol Abisphenol A affects the expression of NKAIN1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of NKAIN1 mRNA15003993
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NKAIN1 mRNA17484886
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of NKAIN1 mRNA19167446
D003520CyclophosphamideNKAIN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
D002945Cisplatin[Cisplatin co-treated with RELB mutant form] results in increased expression of NKAIN1 mRNA23625948
D004026DieldrinDieldrin results in decreased expression of NKAIN1 mRNA28385952
D004317DoxorubicinNKAIN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
D000431EthanolEthanol affects the expression of NKAIN1 mRNA24355176
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of NKAIN1 mRNA28329830
D005472FluorouracilNKAIN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
C039281furanfuran results in increased expression of NKAIN1 mRNA25539665
D017313FenretinideFenretinide results in decreased expression of NKAIN1 mRNA28973697
C045463leflunomideleflunomide results in increased expression of NKAIN1 mRNA28988120
D017239PaclitaxelNKAIN1 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NKAIN1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of NKAIN1 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of NKAIN1 mRNA17426115
D010936Plant ExtractsPlant Extracts results in decreased expression of NKAIN1 mRNA23557933
D011794QuercetinQuercetin results in increased expression of NKAIN1 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of NKAIN1 mRNA19167446
D018038Sodium SeleniteSodium Selenite results in decreased expression of NKAIN1 mRNA18175754
D012999SomanSoman results in increased expression of NKAIN1 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NKAIN1 mRNA20106945|2163298
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of NKAIN1 mRNA28973375
D013853ThioacetamideThioacetamide results in increased expression of NKAIN1 mRNA23411599
D014635Valproic AcidValproic Acid affects the expression of NKAIN1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NKAIN1 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of NKAIN1 gene29154799
C111237vorinostatvorinostat results in decreased expression of NKAIN1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0051117ATPase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002028regulation of sodium ion transport-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23778322Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent. (2013 Aug)Zuo LPharmacogenet Genomics
23455491NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. (2013 May 1)Zuo LDrug Alcohol Depend