Gene: ACSS3

79611
-
acyl-CoA synthetase short chain family member 3
protein-coding
12q21.31
Ensembl:ENSG00000111058 MIM:614356 Vega:OTTHUMG00000170179 UniprotKB:Q9H6R3
NC_000012.12
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.991e-1 (AD)  3.126e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHDH0.908
BMPR1B0.89
TP53BP20.889
PPARA0.888
CYBRD10.887
GRAMD1C0.885
GOLIM40.88
METTL7A0.877
SLC39A120.876
GJA10.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DUSP27-0.53
MCHR1-0.52
OSBPL10-0.517
MYOZ3-0.517
CACNA1F-0.501
AGMAT-0.495
GABRG3-0.493
GALNT14-0.49
IL12RB2-0.487
ABCC12-0.486

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ACSS3 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ACSS3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ACSS3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ACSS3 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ACSS3 mRNA"25510870
D000082AcetaminophenAcetaminophen results in decreased expression of ACSS3 mRNA21420995|2906747
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of ACSS3 mRNA28522335
D001151ArsenicArsenic affects the methylation of ACSS3 gene25304211
C015001arsenitearsenite results in increased methylation of ACSS3 promoter23974009
C006780bisphenol Abisphenol A results in decreased expression of ACSS3 mRNA25181051
D019327Copper SulfateCopper Sulfate results in decreased expression of ACSS3 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of ACSS3 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of ACSS3 mRNA20106945|2556210
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of ACSS3 mRNA28962523
C000944dicrotophosdicrotophos results in decreased expression of ACSS3 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of ACSS3 mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of ACSS3 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of ACSS3 mRNA]19850644
D002117CalcitriolCalcitriol results in increased expression of ACSS3 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of ACSS3 mRNA21592394
D005485FlutamideFlutamide results in decreased expression of ACSS3 mRNA24793618
D007854LeadLead affects the expression of ACSS3 mRNA28903495
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ACSS3 mRNA23179753|2718838
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ACSS3 mRNA26011545
C523799MRK 003MRK 003 results in decreased expression of ACSS3 mRNA21169257
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ACSS3 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ACSS3 mRNA"25620056
D009532NickelNickel results in decreased expression of ACSS3 mRNA25583101
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ACSS3 mRNA"25510870
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ACSS3 mRNA22714537
C045362prochlorazprochloraz results in increased expression of ACSS3 mRNA21470553
D011794QuercetinQuercetin results in decreased expression of ACSS3 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ACSS3 mRNA25895662
D012906SmokeSmoke results in increased expression of ACSS3 mRNA21095227
C017947sodium arsenitesodium arsenite results in increased expression of ACSS3 mRNA22714537
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of ACSS3 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of ACSS3 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ACSS3 mRNA21570461
D014241TrichloroethyleneTrichloroethylene results in increased expression of ACSS3 mRNA25549359
D014520UrethaneUrethane results in decreased expression of ACSS3 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of ACSS3 mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ACSS3 gene25560391
C025643vinclozolinvinclozolin results in increased expression of ACSS3 mRNA23555832

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003987acetate-CoA ligase activity-TAS-  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0046951ketone body biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00640Propanoate metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-74182Ketone body metabolismTAS
R-HSA-77111Synthesis of Ketone BodiesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28550509Possible involvement of ACSS2 gene in alcoholism. (2017 Sep)Ribeiro AFJ Neural Transm (Vienna)