Gene info: ID 79644

Gene: SRD5A3

GENE ID: 79644

Synonyms: CDG1P|CDG1Q|KRIZI|SRD5A2L|SRD5A2L1

Description: steroid 5 alpha-reductase 3

Gene type: protein-coding

Location: 4q12

dbXrefs: Ensembl:ENSG00000128039 MIM:611715 Vega:OTTHUMG00000128733 UniprotKB:Q9H8P0

RefSeq: NG_028230.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.536e-1 (AD) 8.989e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
IFT80	0.851
MRPS9	0.849
GNAI1	0.844
PIGK	0.842
LANCL1	0.841
LIAS	0.841
ADSS	0.839
ANAPC5	0.838
ATP8A1	0.836
FAM98B	0.836

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MTRNR2L6	-0.517
MTRNR2L9	-0.491
MTRNR2L10	-0.482
MTRNR2L2	-0.453
MTRNR2L8	-0.446
TNFRSF10D	-0.427
OR4F5	-0.424
CASP7	-0.418
CSAG1	-0.415
EVC2	-0.414

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00421	Spironolactone	Small Molecule	52-01-7	Approved	Target
DB01420	Testosterone propionate	Small Molecule	57-85-2	Approved\|Investigational\|Withdrawn	Enzyme
DB13943	Testosterone cypionate	Small Molecule	58-20-8	Approved	Enzyme
DB13944	Testosterone enanthate	Small Molecule	315-37-7	Approved	Enzyme
DB13946	Testosterone undecanoate	Small Molecule	5949-44-0	Approved\|Investigational	Enzyme

ID	Drug Name	Action	PubMed
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SRD5A3 mRNA"	19167446
C547124	2,3-dibromopropyl-2,4,6-tribromophenyl ether	"2,3-dibromopropyl-2,4,6-tribromophenyl ether metabolite results in decreased expression of SRD5A3 mRNA"	26318274
C547124	2,3-dibromopropyl-2,4,6-tribromophenyl ether	"2,3-dibromopropyl-2,4,6-tribromophenyl ether results in decreased expression of SRD5A3 mRNA"	26318274
C547124	2,3-dibromopropyl-2,4,6-tribromophenyl ether	"2,3-dibromopropyl-2,4,6-tribromophenyl ether analog results in decreased expression of SRD5A3 mRNA"	25454221
C547124	2,3-dibromopropyl-2,4,6-tribromophenyl ether	"2,3-dibromopropyl-2,4,6-tribromophenyl ether results in decreased expression of SRD5A3 mRNA"	25454221
C008745	4,4'-bisphenol F	"4,4'-bisphenol F results in decreased expression of SRD5A3 mRNA"	26186136
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of SRD5A3 mRNA"	18648102
D000082	Acetaminophen	Acetaminophen results in decreased expression of SRD5A3 mRNA	26690555
D000082	Acetaminophen	Acetaminophen affects the expression of SRD5A3 mRNA	17562736
C000610085	allyl 2,4,6-tribromophenyl ether	"allyl 2,4,6-tribromophenyl ether results in decreased expression of SRD5A3 mRNA"	25454221
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of SRD5A3 mRNA	25454221
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in decreased expression of SRD5A3 mRNA"	25351596
D001280	Atrazine	Atrazine results in increased expression of SRD5A3 mRNA	25929836
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of SRD5A3 mRNA	26186136
C006780	bisphenol A	bisphenol A results in decreased expression of SRD5A3 mRNA	26186136
C006780	bisphenol A	bisphenol A results in decreased expression of SRD5A3 protein	26186136
C006780	bisphenol A	bisphenol A results in increased expression of SRD5A3 mRNA	23405234\|2518105
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of SRD5A3 mRNA	25596134
D002220	Carbamazepine	Carbamazepine affects the expression of SRD5A3 mRNA	25979313
C004656	chloroacetaldehyde	chloroacetaldehyde results in decreased expression of SRD5A3 mRNA	25596134
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SRD5A3 gene	20938992
C059262	cidofovir	cidofovir results in decreased expression of SRD5A3 mRNA	25596134
D004002	Clodronic Acid	Clodronic Acid results in decreased expression of SRD5A3 mRNA	25596134
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of SRD5A3 mRNA	19789285
D019327	Copper Sulfate	Copper Sulfate results in increased expression of SRD5A3 mRNA	19789285
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of SRD5A3 mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SRD5A3 mRNA"	19167446
D016572	Cyclosporine	Cyclosporine results in decreased expression of SRD5A3 mRNA	20106945\|2556210
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of SRD5A3 mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of SRD5A3 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of SRD5A3 mRNA	25596134
D002945	Cisplatin	Cisplatin results in increased expression of SRD5A3 mRNA	27392435
C000944	dicrotophos	dicrotophos results in decreased expression of SRD5A3 mRNA	28302478
D004147	Dioxins	Dioxins affects the expression of SRD5A3 mRNA	20463971
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SRD5A3 mRNA	17942748
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of SRD5A3 mRNA	23649840
D011345	Fenofibrate	Fenofibrate results in decreased expression of SRD5A3 mRNA	25596134
D005485	Flutamide	Flutamide results in increased expression of SRD5A3 mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SRD5A3 gene	20938992
D019833	Genistein	Genistein results in increased expression of SRD5A3 mRNA	20884965
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of SRD5A3 mRNA	20044591
D007069	Ifosfamide	Ifosfamide results in decreased expression of SRD5A3 mRNA	25596134
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of SRD5A3 mRNA	27392435
C410337	K 7174	K 7174 results in decreased expression of SRD5A3 mRNA	24086573
D048628	Ketolides	Ketolides analog results in increased expression of SRD5A3 mRNA	24967691
D008687	Metformin	Metformin results in decreased expression of SRD5A3 mRNA	25596134
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SRD5A3 gene	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of SRD5A3 mRNA	23458150
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of SRD5A3 mRNA	28001369
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of SRD5A3 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of SRD5A3 mRNA	23649840
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of SRD5A3 mRNA	29191790
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of SRD5A3 mRNA"	25554681
C558013	NSC 689534	NSC 689534 results in increased expression of SRD5A3 mRNA	20971185
D010100	Oxygen	Oxygen deficiency affects the expression of SRD5A3 mRNA	25596134
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of SRD5A3 mRNA	23892564
C006253	pirinixic acid	pirinixic acid results in increased expression of SRD5A3 mRNA	18301758\|2381119
C012526	quercitrin	quercitrin results in increased expression of SRD5A3 mRNA	25193878
D015125	Oxyquinoline	Oxyquinoline results in decreased expression of SRD5A3 mRNA	21632981
C059514	resveratrol	resveratrol results in increased expression of SRD5A3 protein	25505154
D012715	Sesame Oil	Sesame Oil results in increased expression of SRD5A3 mRNA	29191790
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of SRD5A3 mRNA	25351596
C016766	sulforafan	sulforafan results in decreased expression of SRD5A3 mRNA	26833863
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SRD5A3 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SRD5A3 mRNA	21215274
D013849	Thimerosal	Thimerosal results in decreased expression of SRD5A3 mRNA	27188386
D013853	Thioacetamide	Thioacetamide results in increased expression of SRD5A3 mRNA	23411599
C406224	valdecoxib	valdecoxib results in increased expression of SRD5A3 mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of SRD5A3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of SRD5A3 mRNA	23179753\|2800136
C088658	zoledronic acid	zoledronic acid results in increased expression of SRD5A3 mRNA	25596134

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	-	IBA	21873635
GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	-	IDA	17986282
GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	-	TAS	-
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	-	IDA	20637498
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	-	TAS	-
GO:0047751	cholestenone 5-alpha-reductase activity	-	IEA	-
GO:0102389	polyprenol reductase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	-	IBA	21873635
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	-	IMP	20637498
GO:0006489	dolichyl diphosphate biosynthetic process	-	TAS	-
GO:0006702	androgen biosynthetic process	-	TAS	-
GO:0016095	polyprenol catabolic process	-	IBA	21873635
GO:0016095	polyprenol catabolic process	-	IDA	20637498
GO:0019348	dolichol metabolic process	-	IDA	20637498
GO:0019408	dolichol biosynthetic process	-	IBA	21873635
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005783	endoplasmic reticulum	-	IBA	21873635
GO:0005783	endoplasmic reticulum	-	IDA	20637498
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0016021	integral component of membrane	-	IEA	-

KEGG ID	KEGG Term
hsa00140	Steroid hormone biosynthesis

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1643685	Disease	TAS
R-HSA-193048	Androgen biosynthesis	TAS
R-HSA-196071	Metabolism of steroid hormones	TAS
R-HSA-3781865	Diseases of glycosylation	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-446193	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	TAS
R-HSA-446199	Synthesis of Dolichyl-phosphate	TAS
R-HSA-446203	Asparagine N-linked glycosylation	TAS
R-HSA-446219	Synthesis of substrates in N-glycan biosythesis	TAS
R-HSA-4755579	Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-5609975	Diseases associated with glycosylation precursor biosynthesis	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-8957322	Metabolism of steroids	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23197595	Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy. (2013 Mar)	O'Shaughnessy PJ	Mol Hum Reprod