Gene: AIMP2

7965
JTV-1|JTV1|P38
aminoacyl tRNA synthetase complex interacting multifunctional protein 2
protein-coding
7p22.1
Ensembl:ENSG00000106305 MIM:600859 Vega:OTTHUMG00000122077 UniprotKB:Q13155
NG_050738.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.343e-1 (AD)  3.698e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RUVBL10.826
DDOST0.81
TFG0.809
STX180.809
RNF1850.806
CTSL0.802
ALYREF0.797
SLC35B10.797
PRPF40.795
GOSR20.793

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.567
OR4F29-0.518
TCL1A-0.283
MTRNR2L9-0.265
KLRK1-0.26
TRPV5-0.247
P2RY14-0.241
OR4F16-0.238
MTRNR2L6-0.227
CTNNA3-0.223

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAIMP2 gene polymorphism affects the susceptibility to Acetaminophen26104854
D000082AcetaminophenAcetaminophen affects the expression of AIMP2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AIMP2 mRNA27153756
D001241AspirinAspirin results in decreased expression of AIMP2 mRNA12800193
D001280AtrazineAtrazine results in decreased expression of AIMP2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AIMP2 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of AIMP2 mRNA28159858
C006780bisphenol Abisphenol A results in increased expression of AIMP2 mRNA25181051
D020148Butyric AcidButyric Acid results in decreased expression of AIMP2 mRNA12800193
C584509C646 compoundC646 compound results in increased expression of AIMP2 mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of AIMP2 mRNA27339419
C018021cobaltous chloridecobaltous chloride results in decreased expression of AIMP2 mRNA19320972|1937684
D019327Copper SulfateCopper Sulfate results in decreased expression of AIMP2 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of AIMP2 mRNA20106945|2556210
C089595cylindrospermopsincylindrospermopsin results in increased expression of AIMP2 mRNA24921660
D013759DronabinolDronabinol results in increased expression of AIMP2 mRNA18454173
C016366dibenzothiophenedibenzothiophene results in increased expression of AIMP2 mRNA23656968
C000944dicrotophosdicrotophos results in increased expression of AIMP2 mRNA28302478
D004026DieldrinDieldrin results in decreased expression of AIMP2 mRNA20438755
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of AIMP2 protein23301498
D000431EthanolEthanol results in decreased expression of AIMP2 protein19609968
D005485FlutamideFlutamide results in increased expression of AIMP2 mRNA24136188
D005897GlafenineGlafenine results in increased expression of AIMP2 mRNA24136188
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AIMP2 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AIMP2 mRNA22904298
D008727MethotrexateMethotrexate affects the expression of AIMP2 mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of AIMP2 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of AIMP2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of AIMP2 mRNA"25554681
C038541N-benzyloxycarbonylprolylprolinalN-benzyloxycarbonylprolylprolinal results in increased expression of AIMP2 mRNA21487212
C051752nefazodonenefazodone results in increased expression of AIMP2 mRNA24136188
C017557nickel subsulfidenickel subsulfide results in increased expression of AIMP2 mRNA21086188
C012655nimesulidenimesulide results in increased expression of AIMP2 mRNA24136188
D010416PentachlorophenolPentachlorophenol results in increased expression of AIMP2 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of AIMP2 mRNA19162173
D010634PhenobarbitalPhenobarbital results in increased expression of AIMP2 mRNA19162173
C006253pirinixic acidpirinixic acid results in decreased expression of AIMP2 mRNA17426115
C045950propiconazolepropiconazole results in increased expression of AIMP2 mRNA21278054
C059514resveratrolresveratrol results in increased expression of AIMP2 protein25505154
C010327salinomycinsalinomycin results in decreased expression of AIMP2 mRNA19682730
D012834SilverSilver affects the expression of AIMP2 mRNA27131904
C016104sodium bichromatesodium bichromate results in increased expression of AIMP2 mRNA25993096
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AIMP2 mRNA21570461|2468072
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AIMP2 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of AIMP2 mRNA23411599
D014212TretinoinTretinoin results in decreased expression of AIMP2 mRNA23724009
D014635Valproic AcidValproic Acid affects the expression of AIMP2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of AIMP2 mRNA19101580
C025643vinclozolinvinclozolin results in decreased expression of AIMP2 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  18695251  19060904  21044950  21285945  21516116  
21536907  21900206  21988832  22190034  23159739  24212136  
25416956  26496610  26871637  27107012  27107014  
GO:0032947protein-containing complex scaffold activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006418tRNA aminoacylation for protein translation-TAS-  
GO:0006915apoptotic process-IEA-  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0031398positive regulation of protein ubiquitination-IEA-  
GO:0060510type II pneumocyte differentiation-IEA-  
GO:0065003protein-containing complex assembly-IEA-  
GO:1901216positive regulation of neuron death-IEA-  
GO:1903632positive regulation of aminoacyl-tRNA ligase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005829cytosol-IDA19289464  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0017101aminoacyl-tRNA synthetase multienzyme complex-IDA19131329  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismIEA
R-HSA-2408517SeMet incorporation into proteinsIEA
R-HSA-2408522Selenoamino acid metabolismIEA
R-HSA-379716Cytosolic tRNA aminoacylationTAS
R-HSA-379724tRNA AminoacylationTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-71291Metabolism of amino acids and derivativesIEA
R-HSA-72766TranslationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28638448Ratio of Autoantibodies of Tumor Suppressor AIMP2 and Its Oncogenic Variant Is Associated with Clinical Outcome in Lung Cancer. (2017)Jung JYJ Cancer