Gene: DYNC2H1

79659
ATD3|DHC1b|DHC2|DNCH2|DYH1B|SRPS2B|SRTD3|hdhc11
dynein cytoplasmic 2 heavy chain 1
protein-coding
11q22.3
Ensembl:ENSG00000187240 MIM:603297 Vega:OTTHUMG00000165941 UniprotKB:Q8NCM8
NG_016423.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.734e-1 (AD)  8.538e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17374436chr11:103185951 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AASDH0.867
VPS13B0.863
KIAA11090.86
AKAP90.85
LONP20.848
TMEM2450.846
TMEM560.845
LRBA0.844
TMEM1920.838
MEGF90.831

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.445
OR4F29-0.405
TFPI2-0.352
FCER2-0.348
MTRNR2L6-0.346
OR4F16-0.344
TTLL10-0.336
PGF-0.332
PPBP-0.329
MTRNR2L9-0.328

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0293704-toluidine4-toluidine results in increased expression of DYNC2H1 mRNA27638505
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DYNC2H1 gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of DYNC2H1 mRNA21757418
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of DYNC2H1 mRNA"25351596
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DYNC2H1 mRNA22316170
C006780bisphenol Abisphenol A results in increased expression of DYNC2H1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of DYNC2H1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of DYNC2H1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of DYNC2H1 promoter22457795
D003010ClorgylineClorgyline results in increased expression of DYNC2H1 mRNA19691856
D019327Copper SulfateCopper Sulfate results in increased expression of DYNC2H1 mRNA19549813
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in decreased expression of DYNC2H1 mRNA21852083
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of DYNC2H1 gene15755804
C544151jinfukangjinfukang results in decreased expression of DYNC2H1 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of DYNC2H1 mRNA15618438
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DYNC2H1 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DYNC2H1 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride affects the expression of DYNC2H1 mRNA20864626
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DYNC2H1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DYNC2H1 mRNA"25554681
D009532NickelNickel results in decreased expression of DYNC2H1 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of DYNC2H1 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of DYNC2H1 mRNA22714537
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in decreased expression of DYNC2H1 mRNA28973697
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of DYNC2H1 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of DYNC2H1 mRNA20813756|2381119
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of DYNC2H1 mRNA19162173
C502851quinocetonequinocetone results in increased expression of DYNC2H1 mRNA27046791
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in decreased expression of DYNC2H1 mRNA21852083
D012822Silicon DioxideSilicon Dioxide results in decreased expression of DYNC2H1 mRNA25351596
C017947sodium arsenitesodium arsenite results in increased expression of DYNC2H1 mRNA17879257
C009495titanium dioxidetitanium dioxide results in decreased expression of DYNC2H1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of DYNC2H1 mRNA28065790
C012589trichostatin Atrichostatin A results in decreased expression of DYNC2H1 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DYNC2H1 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of DYNC2H1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DYNC2H1 mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DYNC2H1 gene25560391
C111237vorinostatvorinostat results in increased expression of DYNC2H1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003774motor activity-NAS8666668  
GO:0005524ATP binding-IEA-  
GO:0008569ATP-dependent microtubule motor activity, minus-end-directed-IBA21873635  
GO:0008569ATP-dependent microtubule motor activity, minus-end-directedcontributes_toIDA21723285  
GO:0045503dynein light chain binding-IBA21873635  
GO:0045505dynein intermediate chain binding-IBA21873635  
GO:0051959dynein light intermediate chain binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007018microtubule-based movement-IBA21873635  
GO:0007030Golgi organization-IDA8666668  
GO:0007368determination of left/right symmetry-IEA-  
GO:0009953dorsal/ventral pattern formation-IEA-  
GO:0016485protein processing-IEA-  
GO:0021522spinal cord motor neuron differentiation-IEA-  
GO:0030326embryonic limb morphogenesis-IEA-  
GO:0030900forebrain development-IEA-  
GO:0035721intraciliary retrograde transport-IBA21873635  
GO:0035735intraciliary transport involved in cilium assembly-TAS-  
GO:0045880positive regulation of smoothened signaling pathway-IEA-  
GO:0060271cilium assembly-IBA21873635  
GO:0060976coronary vasculature development-IEA-  
GO:0061512protein localization to cilium-IEA-  
GO:1905515non-motile cilium assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005794Golgi apparatus-IDA8666668  
GO:0005868cytoplasmic dynein complex-IBA21873635  
GO:0005868cytoplasmic dynein complex-IDA21723285  25830415  
GO:0005874microtubule-IDA21525035  
GO:0005886plasma membrane-IEA-  
GO:0005929cilium-TAS-  
GO:0005930axoneme-IBA21873635  
GO:0030286dynein complex-IBA21873635  
GO:0031514motile cilium-IBA21873635  
GO:0045177apical part of cell-IEA-  
GO:0070062extracellular exosome-HDA19056867  
GO:0097542ciliary tip-TAS-  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04962Vasopressin-regulated water reabsorption
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5610787Hedgehog 'off' stateTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620924Intraflagellar transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal