Gene: NEIL1

79661
FPG1|NEI1|hFPG1
nei like DNA glycosylase 1
protein-coding
15q24.2
Ensembl:ENSG00000140398 MIM:608844 Vega:OTTHUMG00000142821 UniprotKB:Q96FI4
NC_000015.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.553e-3 (AD)  9.997e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STK360.944
CENPT0.932
CUL90.927
TUBGCP60.926
ABCC100.925
ATP13A10.917
IFT1720.917
ZSWIM80.914
POMT10.913
KAT2A0.913

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.539
OR4F29-0.507
AGTR1-0.331
C9orf135-0.321
ZNF114-0.311
HAS2-0.311
CD8B-0.309
LRAT-0.306
IGF2BP2-0.278
TRDN-0.276

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01592IronSmall Molecule7439-89-6ApprovedTarget
DB03754TromethamineSmall Molecule77-86-1ApprovedTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0710232,6-diamino-4-hydroxy-5-formamidopyrimidine"NEIL1 protein affects the metabolism of 2,6-diamino-4-hydroxy-5-formamidopyrimidine"17389588
C0710232,6-diamino-4-hydroxy-5-formamidopyrimidine"NEIL1 protein affects the metabolism of 2,6-diamino-4-hydroxy-5-formamidopyrimidine"20067321
C0710232,6-diamino-4-hydroxy-5-formamidopyrimidine"NEIL1 protein affects the cleavage of 2,6-diamino-4-hydroxy-5-formamidopyrimidine"20067321
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of NEIL1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEIL1 mRNA"27188386
C0395444,6-diamino-5-N-formamidopyrimidine"NEIL1 protein affects the metabolism of 4,6-diamino-5-N-formamidopyrimidine"17389588
C0395444,6-diamino-5-N-formamidopyrimidine"NEIL1 protein affects the cleavage of 4,6-diamino-5-N-formamidopyrimidine"20067321
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEIL1 mRNA"27188386
C0567528,5'-cyclo-2'-deoxyadenosine"NEIL1 protein affects the metabolism of 8,5'-cyclo-2'-deoxyadenosine"20067321
C023650anilineaniline results in increased expression of NEIL123352893
C023650anilineaniline results in increased expression of NEIL1 mRNA21145906
C023650anilineaniline results in increased expression of NEIL1 protein21145906
D001151ArsenicArsenic affects the methylation of NEIL1 gene25304211
C072019benzo(a)pyrene diolepoxide Ibenzo(a)pyrene diolepoxide I results in increased expression of NEIL1 mRNA27694624
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NEIL1 mRNA27694624
C006780bisphenol Abisphenol A affects the expression of NEIL1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of NEIL1 mRNA25181051
D002104CadmiumCadmium results in decreased activity of NEIL1 protein16677676
D002245Carbon DioxideNEIL1 affects the abundance of Carbon Dioxide21285402
C018021cobaltous chloridecobaltous chloride results in decreased expression of NEIL1 mRNA24386269
D003300CopperCopper binds to and affects the folding of and results in decreased activity of NEIL1 protein20622253
D003300CopperCurcumin inhibits the reaction [Copper binds to and results in decreased activity of NEIL1 protein]20622253
D003300Copper[tris(2-carboxyethyl)phosphine co-treated with Edetic Acid] inhibits the reaction [Copper results in decreased activity of NEIL1 protein]20622253
D003474CurcuminCurcumin inhibits the reaction [Copper binds to and results in decreased activity of NEIL1 protein]20622253
D003474CurcuminCurcumin inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein]20622253
D002945CisplatinCisplatin results in decreased expression of NEIL1 mRNA27392435
D004026DieldrinDieldrin results in decreased expression of NEIL1 mRNA20438755
D004041Dietary FatsNEIL1 affects the reaction [Dietary Fats results in decreased expression of COX1 protein]21285402
D004041Dietary FatsNEIL1 affects the reaction [Dietary Fats results in decreased expression of SLCO1A1 mRNA]21285402
D004041Dietary FatsNEIL1 affects the reaction [Dietary Fats results in decreased expression of VDAC1 protein]21285402
D004041Dietary FatsNEIL1 affects the reaction [Dietary Fats results in increased expression of ANXA2 mRNA]21285402
D004041Dietary FatsNEIL1 affects the reaction [Dietary Fats results in increased expression of APOA4 mRNA]21285402
D004041Dietary FatsNEIL1 affects the reaction [Dietary Fats results in increased expression of CFD mRNA]21285402
D004041Dietary FatsNEIL1 affects the reaction [Dietary Fats results in increased expression of LCN2 mRNA]21285402
D004041Dietary FatsNEIL1 affects the reaction [Dietary Fats results in increased expression of LGALS1 mRNA]21285402
D004041Dietary FatsNEIL1 affects the reaction [Dietary Fats results in increased expression of MT2 mRNA]21285402
D004041Dietary FatsNEIL1 affects the reaction [Dietary Fats results in increased expression of NT5E mRNA]21285402
D004041Dietary FatsNEIL1 affects the reaction [Dietary Fats results in increased expression of RCAN2 mRNA]21285402
D004041Dietary FatsNEIL1 affects the reaction [Dietary Fats results in increased expression of S100A10 mRNA]21285402
D004041Dietary FatsNEIL1 affects the reaction [Dietary Fats results in increased expression of SAA1 mRNA]21285402
D004041Dietary FatsNEIL1 affects the reaction [Dietary Fats results in increased expression of SAA2 mRNA]21285402
D004041Dietary FatsNEIL1 affects the susceptibility to Dietary Fats21285402
D004492Edetic AcidEdetic Acid inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein]20622253
D004492Edetic Acid[tris(2-carboxyethyl)phosphine co-treated with Edetic Acid] inhibits the reaction [Copper results in decreased activity of NEIL1 protein]20622253
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of NEIL1 mRNA25198161
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of NEIL1 intron27776689
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased activity of NEIL1 protein20622253
D006861Hydrogen Peroxidetris(2-carboxyethyl)phosphine inhibits the reaction [Hydrogen Peroxide results in decreased activity of NEIL1 protein]20622253
D007501IronCurcumin inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein]20622253
D007501IronEdetic Acid inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein]20622253
D007501IronIron binds to and affects the folding of and results in decreased activity of NEIL1 protein20622253
D007501IronIron binds to and inhibits the reaction [NEIL1 protein binds to FEN1 protein]20622253
D007501IronIron binds to and inhibits the reaction [NEIL1 protein binds to POLB protein]20622253
D009532NickelNickel results in decreased expression of NEIL1 mRNA25583101
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of NEIL1 mRNA25729387
D010100OxygenNEIL1 affects the metabolism of Oxygen21285402
D017382Reactive Oxygen SpeciesNEIL1 protein results in decreased susceptibility to Reactive Oxygen Species26134572
C017947sodium arsenitesodium arsenite affects the methylation of NEIL1 gene28589171
D012969Sodium FluorideSodium Fluoride results in decreased expression of NEIL1 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NEIL1 mRNA21570461
D013893ThiramThiram results in increased expression of NEIL1 mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of NEIL1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of NEIL1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of NEIL1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of NEIL1 mRNA20530235
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of NEIL1 mRNA19042947
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of NEIL1 mRNA29024780
C080938tris(2-carboxyethyl)phosphine[tris(2-carboxyethyl)phosphine co-treated with Edetic Acid] inhibits the reaction [Copper results in decreased activity of NEIL1 protein]20622253
C080938tris(2-carboxyethyl)phosphinetris(2-carboxyethyl)phosphine inhibits the reaction [Hydrogen Peroxide results in decreased activity of NEIL1 protein]20622253
D014502Uranyl NitrateUranyl Nitrate results in increased expression of NEIL1 mRNA26362510
D014635Valproic AcidValproic Acid results in decreased expression of NEIL1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of NEIL1 gene29154799
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEIL1 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of NEIL1 mRNA26272509
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of NEIL1 mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003684damaged DNA binding-IEA-  
GO:0003906DNA-(apurinic or apyrimidinic site) endonuclease activity-IBA21873635  
GO:0003906DNA-(apurinic or apyrimidinic site) endonuclease activity-TAS-  
GO:0008022protein C-terminus binding-IPI17611195  
GO:0008270zinc ion binding-IEA-  
GO:0016798hydrolase activity, acting on glycosyl bonds-IDA17611195  
GO:0019104DNA N-glycosylase activity-IBA21873635  
GO:0019104DNA N-glycosylase activity-TAS-  
GO:0140078class I DNA-(apurinic or apyrimidinic site) endonuclease activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006284base-excision repair-IBA21873635  
GO:0006284base-excision repair-IDA17611195  
GO:0006289nucleotide-excision repair-IEA-  
GO:0006979response to oxidative stress-IDA17611195  
GO:0032074negative regulation of nuclease activity-IDA17611195  
GO:0045008depyrimidination-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA17611195  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005694chromosome-IEA-  
GO:0005737cytoplasm-IDA17611195  
GO:0005815microtubule organizing center-IEA-  
KEGG ID KEGG Term
hsa03410Base excision repair
Reactome ID Reactome Term Evidence
R-HSA-110328Recognition and association of DNA glycosylase with site containing an affected pyrimidineTAS
R-HSA-110329Cleavage of the damaged pyrimidine TAS
R-HSA-5649702APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement PathwayTAS
R-HSA-73884Base Excision RepairTAS
R-HSA-73894DNA RepairTAS
R-HSA-73928DepyrimidinationTAS
R-HSA-73929Base-Excision Repair, AP Site FormationTAS
R-HSA-73933Resolution of Abasic Sites (AP sites)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18155253OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study. (2008 Mar 1)Hatt LMutat Res