Gene: FASTKD1

79675
-
FAST kinase domains 1
protein-coding
2q31.1
Ensembl:ENSG00000138399 MIM:617529 Vega:OTTHUMG00000154953 UniprotKB:Q53R41
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
1.129e-1 (AD)  4.838e-2 (ND)   (Frontal_Cortex)
3.855e-1 (AD)  4.966e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7349274chr2:169529784 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TBCK0.865
MTRF10.862
ARMCX20.851
OGT0.851
ZADH20.849
PDS5A0.845
HINFP0.844
MLLT30.843
RBM480.842
ZNF6380.841

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.579
OR4F29-0.535
KLRB1-0.349
TFPI2-0.331
SDR42E1-0.305
LRAT-0.299
TBX21-0.298
C9orf153-0.29
CEACAM3-0.287
ASB4-0.286

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of FASTKD1 mRNA21420995
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of FASTKD1 mRNA"23195993
D001280AtrazineAtrazine results in decreased expression of FASTKD1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FASTKD1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FASTKD1 mRNA"19150397
D019327Copper SulfateCopper Sulfate results in decreased expression of FASTKD1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of FASTKD1 mRNA20106945
C000944dicrotophosdicrotophos results in decreased expression of FASTKD1 mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of FASTKD1 mRNA19041683
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FASTKD1 mRNA22079256
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of FASTKD1 mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FASTKD1 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of FASTKD1 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of FASTKD1 mRNA26011545
D009532NickelNickel results in decreased expression of FASTKD1 mRNA23195993
D010936Plant ExtractsPlant Extracts results in increased expression of FASTKD1 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FASTKD1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of FASTKD1 mRNA22079256
D011794QuercetinQuercetin results in decreased expression of FASTKD1 mRNA21632981
D012822Silicon DioxideSilicon Dioxide results in decreased expression of FASTKD1 mRNA23221170
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FASTKD1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FASTKD1 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of FASTKD1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of FASTKD1 mRNA23131501
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FASTKD1 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of FASTKD1 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FASTKD1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0004672protein kinase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000959mitochondrial RNA metabolic process-IMP28335001  
GO:0006468protein phosphorylation-IEA-  
GO:0044528regulation of mitochondrial mRNA stability-IMP28335001  
GO:0045333cellular respiration-ISS20869947  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA20869947  28335001  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal