Gene: MANEA

79694
ENDO|hEndo
mannosidase endo-alpha
protein-coding
6q16.1
Ensembl:ENSG00000172469 MIM:612327 Vega:OTTHUMG00000016296 UniprotKB:Q5SRI9
NC_000006.12
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.273e-1 (AD)  5.488e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC35A30.834
SCAF110.814
CDC730.813
POLK0.805
SP30.802
STAM20.792
FNDC3A0.787
EEA10.782
TMED70.781
AQR0.78

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.399
OR4F29-0.378
NPIPA2-0.267
AZU1-0.232
HGFAC-0.224
NANOS3-0.219
HDAC10-0.213
PRTN3-0.207
NKX6-3-0.205
TMEM253-0.204

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MANEA mRNA"19114083
D000082AcetaminophenAcetaminophen results in decreased expression of MANEA mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MANEA gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MANEA mRNA16483693
D001280AtrazineAtrazine results in decreased expression of MANEA mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MANEA mRNA22228805
D004958EstradiolEstradiol results in decreased expression of MANEA mRNA20106945
D004958EstradiolEstradiol results in increased expression of MANEA mRNA19167446
C006780bisphenol Abisphenol A affects the expression of MANEA mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of MANEA mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of MANEA mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MANEA mRNA24982889
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of MANEA promoter22457795
D003010ClorgylineClorgyline results in increased expression of MANEA mRNA19691856
D003042CocaineMANEA gene SNP affects the susceptibility to Cocaine18438686
D019327Copper SulfateCopper Sulfate results in decreased expression of MANEA mRNA19549813
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of MANEA mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of MANEA mRNA20106945
C000944dicrotophosdicrotophos results in decreased expression of MANEA mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of MANEA mRNA25016146
D004237DiuronDiuron results in decreased expression of MANEA mRNA25152437
D004237DiuronDiuron results in increased expression of MANEA mRNA21551480
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MANEA mRNA22079256
D005419FlavonoidsFlavonoids results in increased expression of MANEA mRNA18035473
D005472FluorouracilFluorouracil affects the expression of MANEA mRNA20421339
D005557FormaldehydeFormaldehyde results in decreased expression of MANEA mRNA23649840
C039281furanfuran results in increased methylation of MANEA gene22079235
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MANEA mRNA20044591
C544151jinfukangjinfukang results in decreased expression of MANEA mRNA27392435
C013598methoxyacetic acidmethoxyacetic acid affects the expression of MANEA mRNA20421339
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MANEA mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MANEA mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in decreased expression of MANEA mRNA29191790
C028577monobutyl phthalatemonobutyl phthalate affects the expression of MANEA mRNA20421339
D009532NickelNickel results in decreased expression of MANEA mRNA25583101
D010261ParaoxonParaoxon results in increased expression of MANEA mRNA17223147
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of MANEA mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MANEA mRNA19162173
C006253pirinixic acidpirinixic acid results in increased expression of MANEA mRNA19162173
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MANEA mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MANEA mRNA22079256
D011794QuercetinQuercetin results in decreased expression of MANEA mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of MANEA mRNA19167446
D012402RotenoneRotenone results in decreased expression of MANEA mRNA19013527
C009277sodium arsenatesodium arsenate results in increased expression of MANEA mRNA23922661
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MANEA mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MANEA mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MANEA mRNA19465110
D014212TretinoinTretinoin affects the expression of MANEA mRNA20421339
D014635Valproic AcidValproic Acid results in decreased expression of MANEA mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of MANEA mRNA20421339
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MANEA gene25560391
D014750VincristineVincristine results in decreased expression of MANEA mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004569glycoprotein endo-alpha-1,2-mannosidase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005794Golgi apparatus-IDA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS
R-HSA-964739N-glycan trimming and elongation in the cis-GolgiTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18438686Substance dependence low-density whole genome association study in two distinct American populations. (2008 Jun)Yu YHum Genet
19255376Association of variants in MANEA with cocaine-related behaviors. (2009 Mar)Farrer LAArch Gen Psychiatry
24473444The alpha-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder. (2014 Jan 28)Jensen KPTransl Psychiatry