Gene: LRRK1

79705
RIPK6|Roco1
leucine rich repeat kinase 1
protein-coding
15q26.3
Ensembl:ENSG00000154237 MIM:610986 Vega:OTTHUMG00000165514 UniprotKB:Q38SD2
NG_052791.1
SNP Mapped
3   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.273e-2 (AD)  9.455e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2054128chr15:101001562 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs8038607chr15:100974424 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs12911894chr15:100953634 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg23631321chr15:101587658LRRK1Gene body5.774e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FOCAD0.906
HECW10.902
PTPRT0.9
TMEM2410.897
FMN10.896
LMTK20.893
CACNA1D0.888
CELSR30.888
ARHGAP260.887
HERC10.886

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.555
HEY2-0.552
BCL7C-0.543
YES1-0.524
LRAT-0.511
AQP5-0.5
RARRES2-0.499
RAB13-0.493
RAI14-0.491
S100A1-0.483

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of LRRK1 mRNA"25614096
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of LRRK1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of LRRK1 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRK1 mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to LRRK1 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to LRRK1 protein]26598702
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRK1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of LRRK1 mRNA17562736
D001151ArsenicArsenic affects the methylation of LRRK1 gene25304211
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to LRRK1 protein]26598702
C006632arsenic trioxidearsenic trioxide results in increased expression of LRRK1 mRNA20458559
C547126AZM551248AZM551248 results in decreased expression of LRRK1 mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of LRRK1 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of LRRK1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of LRRK1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LRRK1 mRNA22316170
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of LRRK1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LRRK1 mRNA19770486
C006780bisphenol Abisphenol A results in increased methylation of LRRK1 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of LRRK1 mRNA26079696
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of LRRK1 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of LRRK1 mRNA24386269
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of LRRK1 mRNA21266533
D004041Dietary FatsDietary Fats results in decreased expression of LRRK1 mRNA25016146
D002117CalcitriolCalcitriol results in increased expression of LRRK1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of LRRK1 mRNA21592394
C118739entinostatentinostat results in increased expression of LRRK1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRK1 mRNA"27188386
C540355fenamidonefenamidone results in increased expression of LRRK1 mRNA27029645
D005557FormaldehydeFormaldehyde results in decreased expression of LRRK1 mRNA23649840
C069837fullerene C60fullerene C60 results in increased expression of LRRK1 mRNA19167457
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LRRK1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LRRK1 mRNA24796395
C008261lead acetatelead acetate results in decreased expression of LRRK1 mRNA22609695
D008767Methylmercury Compounds[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in decreased expression of LRRK1 mRNA20020106
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of LRRK1 mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LRRK1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LRRK1 mRNA"25620056
C028007nickel monoxidenickel monoxide results in increased expression of LRRK1 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of LRRK1 mRNA22714537
C006253pirinixic acidpirinixic acid results in decreased expression of LRRK1 mRNA20813756|2381119
D011078Polychlorinated Biphenyls[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in decreased expression of LRRK1 mRNA20020106
C513428pyrachlostrobinpyrachlostrobin results in increased expression of LRRK1 mRNA27029645
D012822Silicon DioxideSilicon Dioxide results in decreased expression of LRRK1 mRNA19073995
D012834SilverSilver results in increased expression of LRRK1 mRNA27131904
D012999SomanSoman results in increased expression of LRRK1 mRNA19281266
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of LRRK1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of LRRK1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LRRK1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LRRK1 mRNA15652763
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LRRK1 mRNA25613284
D014212TretinoinTretinoin results in decreased expression of LRRK1 mRNA23724009
D014212TretinoinTretinoin results in increased expression of LRRK1 mRNA20488242
D014520UrethaneUrethane results in decreased expression of LRRK1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of LRRK1 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions affects the methylation of LRRK1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19712061  20144646  20697350  24510904  24947832  
GO:0005524ATP binding-IEA-  
GO:0005525GTP binding-IEA-  
GO:0042802identical protein binding-IPI19712061  22952686  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IEA-  
GO:0036035osteoclast development-IEA-  
GO:0045453bone resorption-IEA-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IEA-  
GO:0050732negative regulation of peptidyl-tyrosine phosphorylation-IEA-  
GO:0090263positive regulation of canonical Wnt signaling pathway-IGI22899650  
GO:1902533positive regulation of intracellular signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal