Gene: MORC4

79710
ZCW4|ZCWCC2|dJ75H8.2
MORC family CW-type zinc finger 4
protein-coding
Xq22.3
Ensembl:ENSG00000133131 MIM:300970 Vega:OTTHUMG00000022155 UniprotKB:Q8TE76
NG_016392.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNAP230.794
CSF10.788
ACTL6A0.775
MAPKAPK20.767
CBFB0.762
LYAR0.761
SOWAHC0.753
SYNE30.752
BAZ1A0.748
METTL160.746

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.526
FBLN7-0.521
F7-0.52
EIF4E1B-0.517
ABCC12-0.508
BHLHA9-0.503
ABCG4-0.502
KCNS2-0.496
NOS2-0.495
INPP5J-0.495

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MORC4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MORC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MORC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MORC4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of MORC4 mRNA22230336|2906747
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MORC4 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MORC4 mRNA22100608
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of MORC4 mRNA21298039
D001151ArsenicArsenic affects the methylation of MORC4 gene25304211
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of MORC4 mRNA26377693
C006780bisphenol Abisphenol A results in decreased expression of MORC4 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MORC4 mRNA20938992
D019327Copper SulfateCopper Sulfate results in increased expression of MORC4 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of MORC4 mRNA20106945
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MORC4 mRNA27392435
D002945CisplatinCisplatin results in increased expression of MORC4 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of MORC4 mRNA28302478
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MORC4 mRNA20938992
D017313FenretinideFenretinide results in decreased expression of MORC4 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MORC4 mRNA20044591
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MORC4 mRNA27392435
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MORC4 mRNA20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MORC4 mRNA"25620056
C025256nonylphenolnonylphenol results in increased expression of MORC4 mRNA22982499
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of MORC4 mRNA25729387
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of MORC4 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of MORC4 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MORC4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MORC4 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MORC4 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MORC4 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of MORC4 mRNA18301758|2381119
D011192Potassium DichromatePotassium Dichromate affects the expression of MORC4 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of MORC4 mRNA19690047
D011794QuercetinQuercetin results in increased expression of MORC4 mRNA21632981
D012834SilverSilver results in increased expression of MORC4 mRNA28959546
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MORC4 mRNA21570461
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of MORC4 mRNA25729387
D019772TopotecanTopotecan results in increased expression of MORC4 mRNA25729387
D014212TretinoinTretinoin results in increased expression of MORC4 mRNA21934132
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of MORC4 mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MORC4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MORC4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MORC4 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased methylation of MORC4 gene29154799
D024483Vitamin K 3Vitamin K 3 affects the expression of MORC4 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21988832  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25253127Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study. (2015 Sep)Derikx MHGut