Gene: PPCS

79717
-
phosphopantothenoylcysteine synthetase
protein-coding
1p34.2
Ensembl:ENSG00000127125 MIM:609853 Vega:OTTHUMG00000007332 UniprotKB:Q9HAB8
NC_000001.11
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.146e-1 (AD)  7.460e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BPGM0.898
TMEM14B0.889
KHDRBS10.887
DCTN60.887
CHCHD70.886
PRKAG10.885
STX120.885
SKP10.884
SNX40.883
VBP10.881

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.681
OR4F5-0.668
MTRNR2L6-0.326
RAX2-0.315
CELSR1-0.305
MTRNR2L9-0.293
MMP23B-0.293
MTRNR2L10-0.288
EPPIN-0.271
SLC7A9-0.264

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5254852-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole"2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole results in increased expression of PPCS mRNA"27665778
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PPCS mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of PPCS mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of PPCS mRNA17562736
D001280AtrazineAtrazine results in decreased expression of PPCS mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PPCS mRNA19770486
C006780bisphenol Abisphenol A results in increased expression of PPCS mRNA28159858
C006780bisphenol Abisphenol A affects the expression of PPCS mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PPCS mRNA25181051
D002065BuspironeBuspirone results in increased expression of PPCS mRNA24136188
D002104CadmiumCadmium results in increased expression of PPCS mRNA24376830
D002994ClofibrateClofibrate results in increased expression of PPCS mRNA27665778
C018021cobaltous chloridecobaltous chloride results in decreased expression of PPCS mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of PPCS mRNA19549813
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PPCS mRNA23640034
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PPCS mRNA17361019
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of PPCS mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PPCS mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of PPCS mRNA28302478
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PPCS mRNA17555576
D011345FenofibrateFenofibrate results in increased expression of PPCS mRNA27665778
D018120FinasterideFinasteride results in increased expression of PPCS mRNA24136188
D005485FlutamideFlutamide results in decreased expression of PPCS mRNA24793618
D005485FlutamideFlutamide results in increased expression of PPCS mRNA24136188
C039281furanfuran results in increased methylation of PPCS gene22079235
D015248GemfibrozilGemfibrozil results in increased expression of PPCS mRNA27665778
D007213IndomethacinIndomethacin results in increased expression of PPCS mRNA28201806
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PPCS mRNA27392435
D048628KetolidesKetolides analog results in decreased expression of PPCS mRNA24967691
C008261lead acetatelead acetate results in decreased expression of PPCS mRNA21829687
C045463leflunomideleflunomide results in increased expression of PPCS mRNA24136188
D064704LevofloxacinLevofloxacin results in increased expression of PPCS mRNA24136188
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PPCS mRNA23458150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PPCS mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PPCS mRNA23649840
C500085muraglitazarmuraglitazar results in increased expression of PPCS mRNA21515302
C051752nefazodonenefazodone results in increased expression of PPCS mRNA24136188
C012655nimesulidenimesulide results in increased expression of PPCS mRNA24136188
D010416PentachlorophenolPentachlorophenol results in increased expression of PPCS mRNA23892564
D010433PentylenetetrazolePentylenetetrazole affects the expression of PPCS mRNA21503142
C018637phoronephorone affects the expression of PPCS mRNA18198479
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PPCS mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of PPCS mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of PPCS mRNA17426115|1830175
C006253pirinixic acidpirinixic acid results in increased expression of PPCS mRNA27665778
D054328Proton Pump InhibitorsProton Pump Inhibitors results in increased expression of PPCS mRNA25626140
C089730rosiglitazonerosiglitazone results in increased expression of PPCS mRNA21515302
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PPCS mRNA19073995
C009277sodium arsenatesodium arsenate results in decreased expression of PPCS mRNA23922661
C017947sodium arsenitesodium arsenite affects the methylation of PPCS gene28589171
D013629TamoxifenTamoxifen affects the expression of PPCS mRNA17555576
C501413tesaglitazartesaglitazar results in increased expression of PPCS mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PPCS mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PPCS mRNA21215274
C057693troglitazonetroglitazone results in increased expression of PPCS mRNA21515302
C057693troglitazonetroglitazone results in increased expression of PPCS protein21315101
D014520UrethaneUrethane results in decreased expression of PPCS mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PPCS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PPCS mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of PPCS gene29154799
D024483Vitamin K 3Vitamin K 3 affects the expression of PPCS mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004632phosphopantothenate--cysteine ligase activity-IDA11923312  
GO:0004632phosphopantothenate--cysteine ligase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0009108coenzyme biosynthetic process-TAS-  
GO:0015937coenzyme A biosynthetic process-IDA11923312  
GO:0015937coenzyme A biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00770Pantothenate and CoA biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196783Coenzyme A biosynthesisTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-199220Vitamin B5 (pantothenate) metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27208563Epigenetic regulation of neurodevelopmental genes in response to in utero exposure to phthalate plastic chemicals: How can we delineate causal effects? (2016 Jul)Ponsonby ALNeurotoxicology
16731116Preoperative serum fibrinogen level predicts postoperative pulmonary complications after lung cancer resection. (2006 Jun)Song SWAnn Thorac Surg