Gene: PALB2

79728
FANCN|PNCA3
partner and localizer of BRCA2
protein-coding
16p12.2
Ensembl:ENSG00000083093 MIM:610355 Vega:OTTHUMG00000177097 UniprotKB:Q86YC2
NG_007406.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.082e-1 (AD)  6.504e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
THUMPD10.893
TRAPPC110.888
HECTD10.884
LEMD30.884
FAM160B10.882
RIF10.881
RAD170.881
CDC270.88
TRAPPC80.878
CHAMP10.878

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.529
OR4F29-0.5
MTRNR2L6-0.288
MTRNR2L9-0.283
MTRNR2L10-0.274
CSAG1-0.273
NKX6-1-0.268
PPBP-0.266
OR4F16-0.261
PLA2G5-0.243

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PALB2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PALB2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PALB2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PALB2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PALB2 mRNA"25510870
D000082AcetaminophenAcetaminophen results in decreased expression of PALB2 mRNA26690555
C006780bisphenol Abisphenol A results in increased expression of PALB2 mRNA25181051
D002509CephaloridineCephaloridine results in increased expression of PALB2 mRNA18500788
D003078ColchicineColchicine results in decreased expression of PALB2 mRNA24211769
D019327Copper SulfateCopper Sulfate results in decreased expression of PALB2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PALB2 mRNA25562108
D002945CisplatinCisplatin results in decreased expression of PALB2 mRNA24211769
D002945CisplatinCisplatin results in increased phosphorylation of PALB2 protein22006019
D004041Dietary FatsDietary Fats results in increased expression of PALB2 mRNA25016146
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of PALB2 mRNA24211769
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of PALB2 mRNA23649840
D005047EtoposideEtoposide results in decreased expression of PALB2 mRNA24211769
D005485FlutamideFlutamide results in increased expression of PALB2 mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of PALB2 mRNA20655997
D005557FormaldehydeFormaldehyde results in increased expression of PALB2 mRNA23649840
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PALB2 mRNA25613284
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PALB2 mRNA23649840
D016685MitomycinMitomycin results in decreased expression of PALB2 mRNA24211769
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PALB2 mRNA"25510870
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of PALB2 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of PALB2 mRNA20813756
D012834SilverSilver results in decreased expression of PALB2 mRNA26014281
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PALB2 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PALB2 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PALB2 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of PALB2 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PALB2 mRNA28065790
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PALB2 mRNA19042947
D014520UrethaneUrethane results in decreased expression of PALB2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PALB2 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PALB2 gene25560391
D000225AdenineAdenine results in decreased expression of PALB2 mRNA24211769
D015032ZincZinc deficiency results in decreased expression of PALB2 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IDA20871616  
GO:0005515protein binding-IPI17420451  19369211  19423707  19609323  20332121  20871616  
22193777  22244764  22293751  24141787  24485656  25960410  
26649820  
GO ID GO Term Qualifier Evidence PubMed
GO:0000724double-strand break repair via homologous recombination-IDA19369211  19423707  
GO:0000724double-strand break repair via homologous recombination-IMP26323318  
GO:0001756somitogenesis-IEA-  
GO:0001833inner cell mass cell proliferation-IEA-  
GO:0007498mesoderm development-IEA-  
GO:0009887animal organ morphogenesis-IEA-  
GO:0035264multicellular organism growth-IEA-  
GO:0036342post-anal tail morphogenesis-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0048568embryonic organ development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693537Resolution of D-Loop StructuresTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)TAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693568Resolution of D-loop Structures through Holliday Junction IntermediatesTAS
R-HSA-5693579Homologous DNA Pairing and Strand ExchangeTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25813726Gene promoter methylation and DNA repair capacity in monozygotic twins with discordant smoking habits. (2015 Feb)Ottini LMutat Res Genet Toxicol Environ Mutagen
22162228Genetic susceptibility to pancreatic cancer. (2012 Jan)Klein APMol Carcinog
27732944Germline mutations in Japanese familial pancreatic cancer patients. (2016 Nov 8)Takai EOncotarget
26654799Pancreatic Cancer Diagnostics and Treatment--Current State. (2015)Krska ZPrague Med Rep