Gene: SH3D21

79729
C1orf113
SH3 domain containing 21
protein-coding
1p34.3
Ensembl:ENSG00000214193 Vega:OTTHUMG00000007868 UniprotKB:A4FU49
NC_000001.11
SNP Mapped
0   ANCO-SNPs
AD
0   
1.132e-2 (AD)  2.019e-1 (ND)   (Frontal_Cortex)
8.895e-2 (AD)  1.880e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNA1D0.9
RNF1230.9
MROH10.88
ADCY60.88
CACNA1B0.88
SLC29A10.875
HECTD40.874
CELSR30.873
INCENP0.871
MAP3K120.866

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.545
RAB13-0.534
ROM1-0.525
AKR1C3-0.519
MYL3-0.509
NXT2-0.5
YES1-0.499
HEY2-0.491
VAMP5-0.487
ZNF114-0.48

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of SH3D21 mRNA"26377693
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SH3D21 mRNA"19114083
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of SH3D21 mRNA28522335
D001151ArsenicArsenic affects the methylation of SH3D21 gene25304211
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in decreased expression of SH3D21 mRNA25270620
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of SH3D21 mRNA27685785
C006780bisphenol Abisphenol A results in increased methylation of SH3D21 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of SH3D21 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SH3D21 gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of SH3D21 mRNA26079696
D002737ChloropreneChloroprene results in increased expression of SH3D21 mRNA23125180
D019327Copper SulfateCopper Sulfate results in increased expression of SH3D21 mRNA19549813
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of SH3D21 gene23968726
D002117CalcitriolCalcitriol results in increased expression of SH3D21 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of SH3D21 mRNA21592394
D017313FenretinideFenretinide results in decreased expression of SH3D21 mRNA28973697
C544151jinfukangjinfukang results in increased expression of SH3D21 mRNA27392435
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of SH3D21 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SH3D21 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SH3D21 mRNA"25620056
D010100OxygenOxygen deficiency results in increased expression of SH3D21 mRNA26516004
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of SH3D21 gene23968726
D010936Plant ExtractsPlant Extracts results in decreased expression of SH3D21 mRNA23557933
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SH3D21 mRNA25895662
D012969Sodium FluorideSodium Fluoride results in increased expression of SH3D21 mRNA27862939
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of SH3D21 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of SH3D21 mRNA21592394
D014520UrethaneUrethane results in increased expression of SH3D21 mRNA28818685
C025643vinclozolinvinclozolin results in increased expression of SH3D21 mRNA23869203

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005886plasma membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal