Gene: ECHDC3

79746
-
enoyl-CoA hydratase domain containing 3
protein-coding
10p14
Ensembl:ENSG00000134463 Vega:OTTHUMG00000017675 UniprotKB:Q96DC8
NC_000010.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  4.745e-2 (ND)   (Frontal_Cortex)
4.371e-1 (AD)  7.021e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4750099chr10:11753576 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADAMTSL40.723
PODNL10.661
MDK0.656
APOBEC3F0.648
ANG0.63
HMGB20.629
SLC16A130.624
MOV100.607
MYCBP0.604
SP1100.596

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT7A-0.357
VIT-0.303
KCNIP3-0.302
KIT-0.291
CPLX3-0.289
FLRT1-0.287
NPAS1-0.275
HAPLN1-0.275
PHOSPHO1-0.274
PVALB-0.271

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ECHDC3 mRNA"28903501
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ECHDC3 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of ECHDC3 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ECHDC3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ECHDC3 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ECHDC3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ECHDC3 protein20106945
D001280AtrazineAtrazine results in increased expression of ECHDC3 mRNA25929836
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of ECHDC3 mRNA]22228805
C006780bisphenol Abisphenol A results in increased expression of ECHDC3 mRNA25181051
D002065BuspironeBuspirone results in increased expression of ECHDC3 mRNA24136188
D002104CadmiumCadmium results in decreased expression of ECHDC3 mRNA24067728
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ECHDC3 mRNA17484886|2733941
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ECHDC3 mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of ECHDC3 mRNA23811191
D016572CyclosporineCyclosporine results in decreased expression of ECHDC3 mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ECHDC3 mRNA21266533
D004041Dietary FatsDietary Fats results in decreased expression of ECHDC3 mRNA18042831
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ECHDC3 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ECHDC3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ECHDC3 mRNA17942748
D005472FluorouracilECHDC3 protein affects the susceptibility to Fluorouracil16217747
D005485FlutamideFlutamide results in increased expression of ECHDC3 mRNA26485406
D004397FonofosFonofos results in increased methylation of ECHDC3 promoter22847954
D005897GlafenineGlafenine results in decreased expression of ECHDC3 mRNA24136188
D007213IndomethacinIndomethacin results in increased expression of ECHDC3 mRNA28201806
D008694MethamphetamineMethamphetamine results in decreased expression of ECHDC3 mRNA26307267
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ECHDC3 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ECHDC3 mRNA"25554681|2562005
D009532NickelNickel results in decreased expression of ECHDC3 mRNA25583101
C028007nickel monoxidenickel monoxide results in decreased expression of ECHDC3 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of ECHDC3 mRNA22714537
D000073878Palm OilPalm Oil results in decreased expression of ECHDC3 mRNA18042831
D010278ParathionParathion results in increased methylation of ECHDC3 promoter22847954
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ECHDC3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ECHDC3 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ECHDC3 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of ECHDC3 mRNA18445702
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ECHDC3 mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of ECHDC3 mRNA23012394
D011441PropylthiouracilPropylthiouracil results in decreased expression of ECHDC3 mRNA24780913
D011794QuercetinQuercetin affects the expression of ECHDC3 mRNA18178720
D013629TamoxifenTamoxifen affects the expression of ECHDC3 mRNA17555576
D013629TamoxifenTamoxifen results in decreased expression of ECHDC3 mRNA25123088
C012568terbufosterbufos results in increased methylation of ECHDC3 promoter22847954
D013739TestosteroneTestosterone results in decreased expression of ECHDC3 mRNA21669218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ECHDC3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ECHDC3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ECHDC3 mRNA17942748
D013853ThioacetamideThioacetamide results in decreased expression of ECHDC3 mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of ECHDC3 mRNA23557971
D014212TretinoinTretinoin results in decreased expression of ECHDC3 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of ECHDC3 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of ECHDC3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ECHDC3 mRNA23179753|2493525
D014635Valproic AcidValproic Acid affects the expression of ECHDC3 mRNA17292431
D014640VancomycinVancomycin results in increased expression of ECHDC3 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ECHDC3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003824catalytic activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008152metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal