Gene: ELMO3

79767
CED-12|CED12|ELMO-3
engulfment and cell motility 3
protein-coding
16q22.1
Ensembl:ENSG00000102890 MIM:606422 Vega:OTTHUMG00000133570 UniprotKB:Q96BJ8
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.960e-1 (AD)  9.367e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IRF30.709
APBA30.707
TRABD0.701
DDX39A0.7
BAX0.682
RFX10.676
POLD10.674
FAM193B0.665
TYK20.66
RCN30.66

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.4
OR4F29-0.356
PLK4-0.24
ABCD2-0.225
TEX38-0.223
MGAT4C-0.212
HHLA2-0.211
MYL1-0.205
DSG1-0.203
ISM1-0.201

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ELMO3 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ELMO3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ELMO3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ELMO3 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ELMO3 mRNA"25510870
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ELMO3 gene27153756
D000638AmiodaroneAmiodarone results in increased expression of ELMO3 mRNA19774075
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ELMO3 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ELMO3 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ELMO3 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of ELMO3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ELMO3 gene28505145
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ELMO3 mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of ELMO3 mRNA23811191
C018021cobaltous chloridecobaltous chloride results in decreased expression of ELMO3 mRNA24386269
D003471CuprizoneCuprizone results in increased expression of ELMO3 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of ELMO3 mRNA25562108
D004237DiuronDiuron results in decreased expression of ELMO3 mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ELMO3 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ELMO3 mRNA17557909
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ELMO3 mRNA"25620056
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ELMO3 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of ELMO3 mRNA25729387
D017239PaclitaxelPaclitaxel results in increased expression of ELMO3 protein15907983
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ELMO3 mRNA"25510870
D012906SmokeSmoke results in decreased expression of ELMO3 mRNA21095227
C017947sodium arsenitesodium arsenite results in increased expression of ELMO3 mRNA16322246
C016104sodium bichromatesodium bichromate affects the expression of ELMO3 mRNA22110744
D013629TamoxifenTamoxifen affects the expression of ELMO3 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ELMO3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ELMO3 mRNA19770486
D013853ThioacetamideThioacetamide results in decreased expression of ELMO3 mRNA23411599
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ELMO3 mRNA25729387
D014635Valproic AcidValproic Acid results in decreased expression of ELMO3 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of ELMO3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of ELMO3 mRNA17292431|1796380
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ELMO3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI24567399  
GO:0017124SH3 domain binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006909phagocytosis-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0016477cell migration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25594031Hypomethylation and increased expression of the putative oncogene ELMO3 are associated with lung cancer development and metastases formation. (2014)Soes SOncoscience