Gene: TFPI2

7980
PP5|REF1|TFPI-2
tissue factor pathway inhibitor 2
protein-coding
7q21.3
Ensembl:ENSG00000105825 MIM:600033 Vega:OTTHUMG00000022963 UniprotKB:P48307
NG_032914.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.665e-1 (AD)  8.139e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07380959chr7:93520323TFPI25.500e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI0.829
LILRB20.81
SPTLC30.802
EMILIN20.798
KIAA00400.794
FCRLA0.786
TREM10.785
TNFAIP80.777
PLEKHG20.777
LINC001890.775

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNA2-0.643
FUT9-0.64
RNFT2-0.634
BCL11A-0.628
LRTM2-0.62
EXTL1-0.617
CNNM1-0.617
THY1-0.614
ANKRD34A-0.612
CYP46A1-0.611

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TFPI2 mRNA"23146750
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of TFPI2 mRNA"23146750
C0163923,3'-diindolylmethane"3,3'-diindolylmethane results in increased expression of TFPI2 mRNA"16192472
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of TFPI2 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of TFPI2 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of TFPI2 mRNA11264010
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of TFPI2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TFPI2 mRNA]17585979
D020106AcrylamideAcrylamide results in increased expression of TFPI2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TFPI2 protein20106945
D000393Air PollutantsAir Pollutants analog results in increased expression of TFPI2 mRNA21757418
C025154alpha-cobratoxinalpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of TFPI2 mRNA]12588870
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TFPI2 mRNA16483693
C015001arsenitearsenite results in decreased expression of TFPI2 mRNA23974009
D017636Asbestos, Amphibole"Asbestos, Amphibole results in increased expression of TFPI2 mRNA"20831825
D017636Asbestos, Amphibole"Asbestos, Amphibole results in increased expression of TFPI2 mRNA"22352330
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of TFPI2 mRNA"25757056
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of TFPI2 mRNA"18687144|2083182
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of TFPI2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TFPI2 mRNA17879257|2187194
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of TFPI2 mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TFPI2 mRNA19619570
D004958EstradiolEstradiol results in increased expression of TFPI2 mRNA16202921|1961957
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TFPI2 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of TFPI2 mRNA19371625
C006780bisphenol Abisphenol A results in increased methylation of TFPI2 gene28582417
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TFPI2 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of TFPI2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TFPI2 mRNA28628672
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of TFPI2 mRNA20147733|2207961
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of TFPI2 mRNA15336504
D002220CarbamazepineCarbamazepine affects the expression of TFPI2 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TFPI2 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of TFPI2 mRNA27339419
D002330CarmustineTFPI2 mRNA affects the susceptibility to Carmustine16365179
D002737ChloropreneChloroprene results in decreased expression of TFPI2 mRNA23125180
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of TFPI2 mRNA17585979
D002994ClofibrateClofibrate results in increased expression of TFPI2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TFPI2 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of TFPI2 mRNA19320972|1937684
D003078ColchicineColchicine results in increased expression of TFPI2 mRNA20624997
D003300CopperCopper results in decreased expression of TFPI2 mRNA19747488
D019327Copper SulfateCopper Sulfate affects the expression of TFPI2 mRNA19549813
C402665CP 31398CP 31398 results in increased expression of TFPI2 mRNA15155752
D016572CyclosporineCyclosporine results in increased expression of TFPI2 mRNA20106945
C014347decitabine[decitabine co-treated with trichostatin A] affects the methylation of TFPI2 promoter17464989
C014347decitabine[[decitabine co-treated with trichostatin A] affects the methylation of TFPI2 promoter] which affects the expression of TFPI2 mRNA17464989|1746498
C014347decitabinedecitabine results in decreased methylation of TFPI2 promoter19435926
C014347decitabinedecitabine results in increased expression of TFPI2 mRNA19435926
D003907DexamethasoneDexamethasone results in decreased expression of TFPI2 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TFPI2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TFPI2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TFPI2 mRNA28628672
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of TFPI2 mRNA"15735009
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TFPI2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TFPI2 mRNA27392435
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of TFPI2 mRNA28085963
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of TFPI2 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of TFPI2 mRNA]19850644
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of TFPI2 mRNA25380136
D004317DoxorubicinTFPI2 protein affects the susceptibility to Doxorubicin16217747
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of TFPI2 mRNA25198161
D004726EndosulfanEndosulfan results in increased expression of TFPI2 mRNA26615145
C118739entinostatentinostat results in increased expression of TFPI2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI2 mRNA"27188386
D005047EtoposideTFPI2 protein affects the susceptibility to Etoposide16217747
D004397FonofosFonofos results in increased methylation of TFPI2 promoter22847954
C039281furanfuran results in increased expression of TFPI2 mRNA27387713
C010974glyphosateglyphosate results in increased expression of TFPI2 mRNA25636363
D017313FenretinideFenretinide results in increased expression of TFPI2 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TFPI2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TFPI2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TFPI2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TFPI2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TFPI2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TFPI2 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TFPI2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of TFPI2 mRNA27392435
D008154LucanthoneLucanthone results in increased expression of TFPI2 mRNA21148553
C015329lycopenelycopene results in decreased expression of TFPI2 mRNA16886892
D008464MecamylamineMecamylamine inhibits the reaction [Nicotine results in decreased expression of TFPI2 mRNA]12588870
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of TFPI2 mRNA20843944
D008558MelphalanMelphalan results in increased expression of TFPI2 mRNA22363485
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI2 mRNA"27188386
D008727MethotrexateMethotrexate affects the expression of TFPI2 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TFPI2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TFPI2 mRNA26011545
D016685MitomycinTFPI2 protein affects the susceptibility to Mitomycin16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TFPI2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TFPI2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TFPI2 mRNA"25554681|2562005
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of TFPI2 mRNA25380136
C029938nickel sulfatenickel sulfate results in increased expression of TFPI2 mRNA22714537
D009538Nicotinealpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of TFPI2 mRNA]12588870
D009538NicotineMecamylamine inhibits the reaction [Nicotine results in decreased expression of TFPI2 mRNA]12588870
D009538NicotineNicotine results in decreased expression of TFPI2 mRNA12588870
D009538NicotineNicotine results in increased expression of TFPI2 mRNA12588870
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of TFPI2 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of TFPI2 mRNA25729387
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of TFPI2 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of TFPI2 mRNA25658374
D010126OzoneOzone results in decreased expression of TFPI2 mRNA16183385
D010126OzoneOzone results in decreased expression of TFPI2 protein16183385
D017239PaclitaxelTFPI2 protein affects the susceptibility to Paclitaxel16217747
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of TFPI2 mRNA26272509
D010278ParathionParathion results in increased methylation of TFPI2 promoter22847954
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of TFPI2 mRNA26705709
D010634PhenobarbitalPhenobarbital affects the expression of TFPI2 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of TFPI2 mRNA19136022
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TFPI2 mRNA26272509
C006253pirinixic acidpirinixic acid affects the expression of TFPI2 mRNA19136022
C006253pirinixic acidpirinixic acid results in decreased expression of TFPI2 mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of TFPI2 mRNA17426115|1830175
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of TFPI2 mRNA]20059764
D011239PrednisolonePrednisolone results in decreased expression of TFPI2 mRNA17379860
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of TFPI2 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of TFPI2 mRNA21795739
D011794QuercetinQuercetin results in increased expression of TFPI2 mRNA21632981
D011794QuercetinQuercetin affects the expression of TFPI2 mRNA18178720
C059514resveratrolresveratrol results in increased expression of TFPI2 mRNA19371625|2588880
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of TFPI2 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TFPI2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of TFPI2 mRNA25351596
C017947sodium arsenitesodium arsenite results in increased expression of TFPI2 mRNA22714537
C017947sodium arsenitesodium arsenite results in increased expression of TFPI2 mRNA16014739
C047246temozolomideTFPI2 mRNA affects the susceptibility to temozolomide16365179
C012568terbufosterbufos results in increased methylation of TFPI2 promoter22847954
C501413tesaglitazartesaglitazar results in increased expression of TFPI2 mRNA21515302
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TFPI2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TFPI2 mRNA19619570
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TFPI2 mRNA28065790
D019772TopotecanTFPI2 protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of TFPI2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of TFPI2 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of TFPI2 mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of TFPI2 mRNA23724009
D014212TretinoinTretinoin results in increased expression of TFPI2 mRNA21934132|2383079
C012589trichostatin A[decitabine co-treated with trichostatin A] affects the methylation of TFPI2 promoter17464989
C012589trichostatin A[[decitabine co-treated with trichostatin A] affects the methylation of TFPI2 promoter] which affects the expression of TFPI2 mRNA17464989|1746498
C012589trichostatin Atrichostatin A results in increased expression of TFPI2 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TFPI2 mRNA"26743178
D014520UrethaneUrethane results in increased expression of TFPI2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of TFPI2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of TFPI2 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TFPI2 gene25560391
D014747VinblastineTFPI2 protein affects the susceptibility to Vinblastine16217747
D014747VinblastineVinblastine results in increased expression of TFPI2 mRNA20624997
C029297vinylidene chloridevinylidene chloride results in decreased expression of TFPI2 mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TFPI2 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of TFPI2 mRNA26272509
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of TFPI2 mRNA"25198161
D015032ZincZinc results in increased expression of TFPI2 mRNA16870260
C016837zinc chloridezinc chloride results in increased expression of TFPI2 mRNA16870260
C088658zoledronic acidzoledronic acid results in increased expression of TFPI2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004867serine-type endopeptidase inhibitor activity-IBA21873635  
GO:0004867serine-type endopeptidase inhibitor activity-IEA-  
GO:0005201extracellular matrix structural constituent-TAS8914837  
GO ID GO Term Qualifier Evidence PubMed
GO:0007596blood coagulation-IEA-  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0071498cellular response to fluid shear stress-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0031012extracellular matrix-TAS8914837  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22083596Stool DNA testing for the detection of pancreatic cancer: assessment of methylation marker candidates. (2012 May 15)Kisiel JBCancer