Gene: GEMIN6

79833
-
gem nuclear organelle associated protein 6
protein-coding
2p22.1
Ensembl:ENSG00000152147 MIM:607006 Vega:OTTHUMG00000128588 UniprotKB:Q8WXD5
NC_000002.12
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.194e-1 (AD)  6.300e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1056104chr2:38781807 (GRCh38.p7)G>A / G>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRAPPC30.905
RNF80.89
RABIF0.877
MAGEH10.873
HDAC80.872
HSDL10.872
YARS20.871
FAM220A0.87
ZNF3290.867
GNPDA10.866

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.498
OR4F29-0.452
MAGEA12-0.408
SLC2A4-0.408
IL18RAP-0.402
AHSP-0.389
ASB4-0.379
GPRC5C-0.376
MMP9-0.374
TFPI2-0.369

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GEMIN6 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GEMIN6 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GEMIN6 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GEMIN6 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GEMIN6 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GEMIN6 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GEMIN6 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of GEMIN6 mRNA"20406850
D000082AcetaminophenAcetaminophen results in decreased expression of GEMIN6 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of GEMIN6 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of GEMIN6 mRNA28959563
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of GEMIN6 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GEMIN6 mRNA15034205
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GEMIN6 mRNA"19150397|2038263
C044887beta-methylcholinebeta-methylcholine affects the expression of GEMIN6 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of GEMIN6 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of GEMIN6 mRNA25047013
C006780bisphenol Abisphenol A results in increased methylation of GEMIN6 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of GEMIN6 promoter22457795
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of GEMIN6 mRNA24690739
D019327Copper SulfateCopper Sulfate results in decreased expression of GEMIN6 mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of GEMIN6 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of GEMIN6 mRNA20106945|2556210
D003907DexamethasoneDexamethasone results in increased expression of GEMIN6 mRNA25047013
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of GEMIN6 mRNA24690739
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GEMIN6 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GEMIN6 mRNA22079256
D005485FlutamideFlutamide results in increased expression of GEMIN6 mRNA24136188
D019833GenisteinGenistein results in decreased expression of GEMIN6 mRNA24967385
C492448ICG 001ICG 001 results in increased expression of GEMIN6 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of GEMIN6 mRNA25613284
C410337K 7174K 7174 results in decreased expression of GEMIN6 mRNA24086573
C045463leflunomideleflunomide results in increased expression of GEMIN6 mRNA24136188
D008777MethyltestosteroneMethyltestosterone results in decreased expression of GEMIN6 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GEMIN6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GEMIN6 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of GEMIN6 mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of GEMIN6 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of GEMIN6 mRNA25729387
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of GEMIN6 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of GEMIN6 mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of GEMIN6 mRNA23091169
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GEMIN6 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GEMIN6 mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of GEMIN6 mRNA18037150
D011794QuercetinQuercetin results in decreased expression of GEMIN6 mRNA21632981
D012715Sesame OilSesame Oil results in increased expression of GEMIN6 mRNA29191790
D012834SilverSilver results in decreased expression of GEMIN6 mRNA26014281
C017947sodium arsenitesodium arsenite results in increased expression of GEMIN6 mRNA28595984
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GEMIN6 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GEMIN6 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GEMIN6 mRNA15034205
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of GEMIN6 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of GEMIN6 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of GEMIN6 mRNA23724009
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of GEMIN6 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GEMIN6 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of GEMIN6 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GEMIN6 mRNA23179753|2915479
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GEMIN6 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of GEMIN6 mRNA20044591
C111237vorinostatvorinostat results in increased expression of GEMIN6 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11748230  12065586  15848170  15939020  16189514  22190034  
25416956  26496610  
GO ID GO Term Qualifier Evidence PubMed
GO:0000245spliceosomal complex assembly-IEA-  
GO:0000387spliceosomal snRNP assembly-IDA18984161  
GO:0000387spliceosomal snRNP assembly-TAS11748230  
GO:0000398mRNA splicing, via spliceosome-TAS11748230  
GO:0051170import into nucleus-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA11748230  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA11748230  
GO:0005829cytosol-IDA18984161  
GO:0005829cytosol-TAS-  
GO:0016604nuclear body-IDA11748230  
GO:0032797SMN complex-IDA18984161  
GO:0034719SMN-Sm protein complex-IDA18984161  
GO:0097504Gemini of coiled bodies-IDA20513430  
KEGG ID KEGG Term
hsa03013RNA transport
Reactome ID Reactome Term Evidence
R-HSA-191859snRNP AssemblyTAS
R-HSA-194441Metabolism of non-coding RNATAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal