Gene: PIP4K2C

79837
PIP5K2C
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
protein-coding
12q13.3
Ensembl:ENSG00000166908 MIM:617104 Vega:OTTHUMG00000170144 UniprotKB:Q8TBX8
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.627e-1 (AD)  7.864e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LMTK20.96
ATP1A10.958
MADD0.957
NLK0.955
RBFOX20.955
PPP2R5D0.955
MYH100.955
ATP2A20.954
KAT70.953
KALRN0.953

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.507
HEY2-0.468
OR4F29-0.465
MYL3-0.453
RAI14-0.441
YES1-0.435
TFPI2-0.429
KLRB1-0.425
LRAT-0.417
MTRNR2L6-0.414

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PIP4K2C mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of PIP4K2C mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of PIP4K2C mRNA15606129|1756273
D020106AcrylamideAcrylamide results in increased expression of PIP4K2C mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PIP4K2C gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PIP4K2C mRNA16483693
C006632arsenic trioxidePIP4K2C protein results in increased susceptibility to arsenic trioxide22496355
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PIP4K2C mRNA18164116
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of PIP4K2C mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PIP4K2C mRNA15034205
C006780bisphenol Abisphenol A results in increased expression of PIP4K2C mRNA25181051
D020148Butyric AcidButyric Acid results in increased expression of PIP4K2C mRNA12800193
D016572CyclosporineCyclosporine results in increased expression of PIP4K2C mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PIP4K2C mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of PIP4K2C mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PIP4K2C mRNA18164116
D002117CalcitriolCalcitriol results in increased expression of PIP4K2C mRNA26485663
C024629dimethyl phthalatedimethyl phthalate affects the expression of PIP4K2C mRNA26924002
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of PIP4K2C mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of PIP4K2C mRNA23649840
D005897GlafenineGlafenine results in decreased expression of PIP4K2C mRNA24136188
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PIP4K2C mRNA23649840
C028007nickel monoxidenickel monoxide results in increased expression of PIP4K2C mRNA19167457
D011192Potassium DichromatePotassium Dichromate results in increased expression of PIP4K2C protein23718831
C015586propiverinepropiverine binds to PIP4K2C protein29273565
C059514resveratrolresveratrol results in increased expression of PIP4K2C protein25505154
D012999SomanSoman results in decreased expression of PIP4K2C mRNA19281266
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PIP4K2C mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PIP4K2C mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PIP4K2C mRNA15034205
C012589trichostatin Atrichostatin A affects the expression of PIP4K2C mRNA28542535
D014520UrethaneUrethane results in increased expression of PIP4K2C mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PIP4K2C mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PIP4K2C mRNA23179753|2800136
D014635Valproic AcidValproic Acid affects the expression of PIP4K2C mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PIP4K2C gene25560391
D014810Vitamin EVitamin E results in increased expression of PIP4K2C mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IEA-  
GO:00163091-phosphatidylinositol-5-phosphate 4-kinase activity-EXP23758345  25495341  
GO:0042802identical protein binding-IPI18255255  
GO ID GO Term Qualifier Evidence PubMed
GO:0006661phosphatidylinositol biosynthetic process-TAS-  
GO:0010506regulation of autophagy-IMP25578879  
GO:0014066regulation of phosphatidylinositol 3-kinase signaling-TAS-  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:2000786positive regulation of autophagosome assembly-IMP25578879  
GO ID GO Term Qualifier Evidence PubMed
GO:0005776autophagosome-IMP25578879  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IEA-  
GO:0070062extracellular exosome-HDA18570454  19056867  
KEGG ID KEGG Term
hsa00562Inositol phosphate metabolism
hsa04070Phosphatidylinositol signaling system
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1430728MetabolismTAS
R-HSA-1483255PI MetabolismTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1660499Synthesis of PIPs at the plasma membraneTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-6804758Regulation of TP53 Activity through AcetylationTAS
R-HSA-6811555PI5P Regulates TP53 AcetylationTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8847453Synthesis of PIPs in the nucleusTAS
R-HSA-9006925Intracellular signaling by second messengersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20439292Genetic variants in the prediction of rheumatoid arthritis. (2010 Sep)van der Helm-van Mil AHAnn Rheum Dis