Gene: TREML2

79865
C6orf76|TLT-2|TLT2|dJ238O23.1
triggering receptor expressed on myeloid cells like 2
protein-coding
6p21.1
Ensembl:ENSG00000112195 MIM:609715 Vega:OTTHUMG00000016349 UniprotKB:Q5T2D2
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.946e-1 (AD)  4.180e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FPR20.841
TLR80.781
LILRB20.774
LILRB30.77
TNFRSF10C0.763
IL18RAP0.756
GPR650.754
CR10.748
CEACAM40.738
TREM10.728

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.477
CHRNA4-0.473
ANKRD34A-0.472
NNAT-0.47
LRTM2-0.467
TMEM179-0.466
EXTL1-0.466
CDK5R2-0.465
RNFT2-0.461
MAGIX-0.459

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TREML2 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of TREML2 mRNA25181051
D002945CisplatinCisplatin results in increased expression of TREML2 mRNA27594783
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TREML2 mRNA25613284
D007501IronIron deficiency results in increased expression of TREML2 mRNA20368581
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TREML2 mRNA26752646
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TREML2 mRNA"25554681
C005556propionaldehydepropionaldehyde results in decreased expression of TREML2 mRNA26079696
D012834SilverSilver results in decreased expression of TREML2 mRNA27131904
C016766sulforafansulforafan results in increased expression of TREML2 mRNA26833863
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TREML2 mRNA25613284

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18650384  
GO:0038023signaling receptor activity-IDA18650384  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IEA-  
GO:0042110T cell activation-IDA18650384  
GO:0050776regulation of immune response-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IDA18650384  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24142389Male-specific genetic effect on hypertension and metabolic disorders. (2014 Mar)Heo SGHum Genet